Definitive intensity-modulated radiation therapy for nasopharyngeal carcinoma: long-term outcome of a multicenter prospective study

Wang, Rensheng; Wu, Fang; Lu, Hongsheng; Wei, Bo; Feng, Guosheng; Li, Guisheng; Liu, Meilian; Yan, Haolin; Jin, Zhu; Zhang, Yong; Hu, Kai

doi:10.1007/s00432-012-1313-0

Cited by 48 publications

(33 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, IMRT has its own risks, including marginal miss, which may lead to tumor recurrence 35,36 . Furthermore, even with the use of IMRT, a significant proportion of patients still develop long term xerostomia 37 . Even “dose sparing” approaches that preferentially minimize radiation to one of the two parotid glands may reduce salivary output of the spared gland by up to 50% 38 .…”

Section: Discussionmentioning

confidence: 99%

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model

Ashcraft

Boss

Tovmasyan

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

Purpose Normal tissue injury is dose limiting for radiotherapy (RT) in nearly every application. This provides strong rationale for developing new classes of novel radioprotectors. The caveat is that radioprotective drugs must be selective for normal tissue and not tumor. Here we tested the effects of a novel Mn porphyrin oxidative stress modifier, MnBuOE for its radioprotective and radiosensitizing properties in normal tissue vs. tumor, respectively. Methods Murine oral mucosa and salivary glands were treated with a range of radiation doses, ±MnBuOE to establish the dose effect curves for mucositis and xerostomia. Radiation injury was quantified by intravital NIR imaging of cathepsin activity, assessment of salivation and histological analysis. To evaluate effects of MnBuOE on the tumor radiation response, we administered the drug as an adjuvant to fractionated radiation of FaDu xenografts. Again, a range of RT doses were administered to establish the radiation dose effect curve. The TCD50 values ±MnBuOE and dose modifying factor were determined. Results MnBuOE protected normal tissue by reducing RT-mediated mucositis, xerostomia and fibrosis. The dose modifying factor for protection against xerostomia was 0.77. In contrast, MnBuOE increased tumor local control rates, compared to controls. The dose modifying factor, based on the ratio of TCD50 values, was 1.3. Immunohistochemistry showed that MnBuOE-treated tumors exhibited a significant influx of M1 tumor-associated macrophages, which provides mechanistic insight into its radiosensitizing effects in tumors. Conclusions MnBuOE widens the therapeutic margin by decreasing the dose of radiation required to control tumor, while increasing normal tissue resistance to RT-mediated injury. This is the first study to quantitatively demonstrate the magnitude of a single drug’s ability to radioprotect normal tissue while radiosensitizing tumor.

show abstract

Section: Discussionmentioning

confidence: 99%

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model

Ashcraft

Boss

Tovmasyan

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

show abstract

“…Radiation treatments to head and neck can damage salivary glands, causing a marked decrease in saliva production (21) Sjögren's syndrome is an autoimmune disease characterized by dryness of the mouth and eyes. Autoimmune diseases feature the abnormal production of extra antibodies in the blood that are directed against various tissues of the body (22).…”

mentioning

confidence: 99%

Update knowledge of dry mouth- A guideline for dentists

Altamimi¹

2014

Afr H. Sci.

View full text Add to dashboard Cite

Background: Dry mouth is usually caused by a reduced salivary flow or by changes in the biochemical composition of saliva. Objective: The aim of this paper is a review of the update literature of dry mouth. Methods: We search in pubmed in the past 10 years using the words «dry mouth», «causes», «symptoms», «treatment» and «dentistry». A large number of papers have been identified. Papers not relevant to the issue were removed reducing the entries to 56 only. Results: There are no clearly established protocols for the treatment of dry mouth in the literature. Most of identified papers were systematic reviews, non-systematic reviews, and observational studies. The most studied patients were Sjögren's syndrome and the irradiated patients. Treatments are focused on the etiology, prevention, symptomatic, local salivary stimulation and systemic treatments. Conclusion: It can be concluded that there is no clear evidence for the causes and treatment of dry mouth, therefore the majority of the general dental practitioners refer most of the cases to appropriate specialist. Treatment must be individualized, salivary substitutes and mechanical stimulation techniques can be applied.

show abstract

“…However, no phase-III randomized trials have as yet compared IMRT versus 3D conformal RT. Several teams have published results, but retrospectively; the RTOG 0225 study is a non-randomized phase-II trial [13,14,16,[24][25][26][27][28][29][30][31] (cf. Table 2).…”

Section: Local Controlmentioning

confidence: 99%

Intensity modulated radiation therapy in nasopharyngeal carcinoma

Haberer-Guillerm¹,

Touboul²,

Huguet³

2015

European Annals of Otorhinolaryngology, Head and Neck Diseases

View full text Add to dashboard Cite

Radiation therapy (with associated chemotherapy) is the standard treatment for nasopharyngeal carcinoma. Conformal intensity-modulated radiation therapy is a new and particularly interesting technique for these tumors, due to their complex volumes close to many critical organs. Better dosimetric results and improved protection of adjacent healthy tissue have been shown compared with conventional 2D or 3D radiation therapy, with significantly reduced side-effects, notably xerostomia. Excellent local control rates have been reported.

show abstract

Definitive intensity-modulated radiation therapy for nasopharyngeal carcinoma: long-term outcome of a multicenter prospective study

Cited by 48 publications

References 20 publications

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model

Update knowledge of dry mouth- A guideline for dentists

Intensity modulated radiation therapy in nasopharyngeal carcinoma

Contact Info

Product

Resources

About