Definitive and adjuvant radiation therapy for external auditory canal and temporal bone squamous cell carcinomas: Long term outcomes

Laskar, Sarbani Ghosh; Sinha, Shwetabh; Pai, Prathamesh; Nair, Deepa; Budrukkar, Ashwini; Swain, Monali; Kimar, Anuj; Moiyadi, Aliasgar; Shetty, Prakash; Roy, Vedanta; Johnny, Carlton; Murthy, Vedang; Gupta, Tejpal; Menon, Nandini; Patil, Vijay; Noronha, Vanita; Joshi, Amit; Prabhash, Kumar; Agarwal, Jai Prakash

doi:10.1016/j.radonc.2022.02.021

Cited by 5 publications

(7 citation statements)

References 25 publications

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“… 10 Similarly, another well‐known staging system, the MPB staging system (derived from EACSCC), has also been investigated as a significant prognostic factor for patients with TBSCC by numerous studies. 6 , 8 , 9 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 Nevertheless, most of these studies only confirmed the MPB‐T classification as a significant prognostic factor rather than the overall stage, which is consistent with our results. Meanwhile, the majority of the above‐mentioned studies included a heterogeneous population of patients with TBSCC, which mainly consisted of patients with EACSCC; thus, the validity of the MPB‐T classifications for MESCC remains unclear.…”

Section: Discussionsupporting

confidence: 91%

“…Thus, generalization of these results to the entire TBC population may yield inadequate accuracy and reliability 10 . Similarly, another well‐known staging system, the MPB staging system (derived from EACSCC), has also been investigated as a significant prognostic factor for patients with TBSCC by numerous studies 6,8,9,11–18 . Nevertheless, most of these studies only confirmed the MPB‐T classification as a significant prognostic factor rather than the overall stage, which is consistent with our results.…”

Section: Discussionsupporting

confidence: 79%

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Clinical outcomes of temporal bone squamous cell carcinoma: A single‐institution experience

Zheng

Qiu

et al. 2022

Cancer Medicine

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Objectives: This study aimed to investigate the survival outcomes and poten tial prognostic factors of patients with temporal bone squamous cell carcinoma (TBSCC) treated at our institution. Methods:We retrospectively included patients who were diagnosed with TBSCC between 2008 and 2019. The Kaplan-Meier (KM) method was used to describe overall survival (OS), and the association between baseline characteristics and prognoses was examined using Cox proportional hazards models.Results: Fifty consecutive patients with TBSCC were included in this study. The results showed that patients with advanced modified Pittsburgh (MPB) T classi fications had a poorer prognosis (T3 vs.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 79%

Clinical outcomes of temporal bone squamous cell carcinoma: A single‐institution experience

Zheng

Qiu

et al. 2022

Cancer Medicine

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“…It is well known that the prognosis for patients with TBSCC treated with chemo-radiotherapy alone is unsatisfactory [ 2 ]. Neoadjuvant chemotherapy has recently been described as an option to downstage borderline resectable tumors to aid margin free excision [ 45 ]. The role of chemotherapy has not been fully defined, but its application, as well as other non-surgical palliative treatments (radiotherapy, or specialist palliative care) are recommended for patients with loco-regionally advanced recurrent TBSCC [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Survival Outcomes in Squamous Cell Carcinoma of the External Auditory Canal: A Systematic Review and Meta-Analysis

Cazzador

Franz

Tealdo

et al. 2023

JCM

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Squamous cell carcinomas (SCC) of the external auditory canal (EAC) are rare tumors representing a surgical challenge. Current knowledge is based largely on case series; thus, the level of evidence is weak. This study sought to systematically review the available SCC of the EAC literature and to identify risk factors for overall survival (OS) and disease-specific survival (DSS). A systematic review and meta-analysis of papers searched up to December 2022 through PubMed, Scopus, Web of Science, and Cochrane Library databases was conducted. Quality assessment of the eligible studies was done according to the Newcastle-Ottawa Scale. Pooled univariate and multivariable analyses and meta-analysis using a random-effects or fixed-effects Mantel-Haenszel model were performed. Fifteen articles (282 patients) met the inclusion criteria and were included in the quantitative analysis. The pooled multivariable analysis revealed cT3 and cT4 as independent prognostic factors for OS (p = 0.005, and p < 0.001, respectively) and DSS (p = 0.002, and p < 0.001, respectively). Local recurrence rate was 32.3%. The meta-analysis estimated significantly higher odds ratios for advanced T categories, than cT1-T2 tumors for OS and DSS (OR = 3.55; 95% CI, 1.93–6.52, and OR = 3.73; 95% CI, 2.00–6.97, respectively). In conclusion, locally advanced tumors were associated with poor prognosis. Poor outcomes mostly occurred due to local recurrence.

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“…The importance of adjuvant radiotherapy and chemotherapy usually varies in different tumor types. At present, surgical resection combined with adjuvant radiotherapy is a standard therapeutic regimen for EACC patients [6, [42][43][44], especially for advanced EACC patients [45][46][47]. Adjuvant radiotherapy is also recommended in some early-stage EACC patients with some risk factors, such as positive surgical margin, parotid gland invasion, bone invasion, and peripheral nerve invasion [2,33,35,48].…”

Section: Discussionmentioning

confidence: 99%

Nutrition-immune-inflammation score (NIIS) plays an important role in the prognosis of postoperative external auditory canal carcinoma patients

Cheng,

Xu,

et al. 2023

Preprint

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Background External auditory canal carcinoma (EACC) was a rare malignant tumor. This study aimed to investigate the influence of the comprehensive index of nutrition-immune-inflammation score (NIIS) on the prognosis of EACC patients with surgical resection. Methods A total of 45 EACC patients with surgical resection were selected from two tertiary medical institutions, and were diagnosed between July 2012 and May 2018. NIIS was calculated by integrating the values of body mass index (BMI), C-reactive protein (CRP), lymphocytes, albumin, and hemoglobin. The relationship between NIIS and prognosis was analyzed by a Log-rank test and displayed by Kaplan-Meier plot. Result The 3- and 5-year survival rate for EACC patients with surgical resection were 70.7%, 61.3% for OS, and 55.6%, 51.1% for PFS, respectively. Most patients with EACC have a nutrition-immune-inflammation score (NIIS) of 4–5 (44.4%). EACC patients with a high score of NIIS tend to have poorer OS (P = 0.001) and PFS (P < 0.001) in comparison with a low score of NIIS. Only a small minority of patients with EACC accept adjuvant radiotherapy (37.8%), and adjuvant chemotherapy (15.6%). Adjuvant radiotherapy had benefit in improving the OS for EACC patients with surgical resection (P = 0.027). However, the adjuvant treatment had no benefit for PFS in postoperative EACC patients (P > 0.05). Conclusion NIIS is an important predictor for predicting the prognosis of EACC patients with surgical resection. Adjuvant radiotherapy was recommended in the application of EACC patients with surgical resection, but not adjuvant chemotherapy. Our findings would have a vital effect on treatment choice and clinical management for both EACC patients and clinicians.

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Definitive and adjuvant radiation therapy for external auditory canal and temporal bone squamous cell carcinomas: Long term outcomes

Cited by 5 publications

References 25 publications

Clinical outcomes of temporal bone squamous cell carcinoma: A single‐institution experience

Clinical outcomes of temporal bone squamous cell carcinoma: A single‐institution experience

Survival Outcomes in Squamous Cell Carcinoma of the External Auditory Canal: A Systematic Review and Meta-Analysis

Nutrition-immune-inflammation score (NIIS) plays an important role in the prognosis of postoperative external auditory canal carcinoma patients

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