Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome

Hart, Roger; Hickey, Martha

doi:10.1016/j.bpobgyn.2004.05.001

Cited by 299 publications

(198 citation statements)

References 69 publications

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“…It is the most common endocrinopathy in women of this age group [1,2]. Left ventricular (LV) diastolic dysfunction is an early sign of cardiomyopathy in PCOS patients [3].…”

Section: Introductionmentioning

confidence: 99%

The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome

Demirelli¹,

Değirmenci²,

Ermis³

et al. 2015

Biomol Biomed

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Polycystic ovary syndrome (PCOS) is characterized by hormonal and metabolic abnormalities and is thought to increase a risk for cardiovascular diseases. In this study we use speckle tracking echocardiography (STE) to evaluate left ventricular (LV) dysfunction in the early period of the disease. We enrolled 31 patients with PCOS and 32 healthy volunteers as a control group. The participants' ages ranged between 18 and 40 years. PCOS was diagnosed according to the Rotterdam criteria. LV strain (LS) and strain rate (SR) were evaluated using apical two-chamber (2C), three-chamber (3C), and four-chamber (4C) imaging. Global LS and SR were calculated as average of three apical views. The waist-to-hip ratio, homeostasis model assessment-insulin resistance (HOMA-IR), and fasting insulin and triglyceride levels were higher in the PCOS group than in the controls (p = 0.001, p = 0.001, p = 0.001, and p = 0.005, respectively). In the PCOS group, the mitral A wave, deceleration time (DT), and isovolumetric relaxation time (IVRT) were significantly higher than in the controls (all p < 0.05). The LV global longitudinal strain (GLS) and global longitudinal SR systolic (GLSRS) were significantly lower in the PCOS patient group (both p = 0.001). There were strong negative correlations between GLS and both fasting insulin (r = −0.64) and DT (r = -0.62) (both p < 0.05). The study demonstrated that PCOS patients had decreased LV function using STE. Therefore, STE imaging appears to be useful for the early detection of subclinical LV dysfunction in patients with PCOS.

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“…It is the most common endocrinopathy in women of this age group [1,2]. Left ventricular (LV) diastolic dysfunction is an early sign of cardiomyopathy in PCOS patients [3].…”

Section: Introductionmentioning

confidence: 99%

The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome

Demirelli¹,

Değirmenci²,

Ermis³

et al. 2015

Biomol Biomed

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“…Functional ovarian hyperandrogenism (FOH) is characterized by hyperandrogenism which is associated with impaired glucose tolerance, hypertension, dyslipidemia and elevated endothelial dysfunction, and these abnormalities contribute to increased risks for future cardiovascular diseases and type 2 diabetes mellitus (T2DM) [1]. FOH is an ovarian dysfunction caused by excess circulating levels of androgens, which inhibit folliculogenesis and lead to poly follicular morphology.…”

Section: Introductionmentioning

confidence: 99%

Correlations of Insulin Resistance and Serum Testosterone Levels with LH:FSH Ratio and Oxidative Stress in Women with Functional Ovarian Hyperandrogenism

Suresh

Vijayakumar

2014

Ind J Clin Biochem

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Functional ovarian hyperandrogenism (FOH) is a form of polycystic ovary syndrome (PCOS) characterized by elevated circulating levels of androgens derived from the ovary. Insulin resistance (IR) is the most common etiological factor in women with FOH. IR causes the generation of increased oxidative stress (OS) and diminished antioxidant status. OS is directly correlated with both IR and testosterone levels, which consequently contribute to endocrine and biochemical alterations in FOH women. In the current study, elevations in total testosterone, free testosterone and luteinizing hormone (LH) levels accompanied by a decrease in follicle stimulating hormone (FSH) level leading to higher LH:FSH ratio were the prominent endocrine changes observed in women with FOH. A significant increase in fasting blood levels of glucose and insulin, as well as an elevated IR were also seen in FOH women, as compared to their age matched controls. Women with FOH have higher pro-oxidant and lower antioxidant levels in blood than their age matched controls. In FOH women, elevations in LH:FSH ratio and OS are correlated more with hyperandrogenemia than with IR. Of the androgens, free rather than total testosterone has better positive correlations with elevated LH:FSH ratio and OS, and hence, the former is a better predictive marker for the development of biochemical PCOS in women with FOH.

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“…The polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting an estimated 5-10 % of adult women and diagnosed frequently during adolescence [1][2][3]. PCOS is primarily characterized by anovulation, hyperandrogenism, insulin resistance and polycystic ovaries by ultrasonography in most patients [4,5].…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis on the association between PPAR-γ Pro12Ala polymorphism and polycystic ovary syndrome

Wang

Liu

et al. 2012

J Assist Reprod Genet

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Purpose To investigate the influence of the peroxisome proliferator activated receptor gamma (PPAR-γ) Pro12Ala polymorphism on the susceptibility of polycystic ovary syndrome (PCOS) and body mass index (BMI), fast insulin levels, homeostasis model assessment of insulin resistance (HOMA-IR) in PCOS patients. Methods PubMed, EMBASE, MEDLINE and CENTRAL databases were searched to identify eligible studies. We then conducted a meta-analysis to examine the association between Pro12Ala polymorphism and PCOS. Results Seventeen eligible studies, including 2,149 patients and 2,124 controls were enrolled in this meta-analysis. Conclusions Ala variant would decrease the risk of PCOS and result in lower BMI and fast insulin levels in a European population, but had no impact on HOMA-IR in PCOS patients. Further studies are required to elucidate these associations more clear.

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Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome

Cited by 299 publications

References 69 publications

The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome

The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome

Correlations of Insulin Resistance and Serum Testosterone Levels with LH:FSH Ratio and Oxidative Stress in Women with Functional Ovarian Hyperandrogenism

A meta-analysis on the association between PPAR-γ Pro12Ala polymorphism and polycystic ovary syndrome

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