Definitions and treatment of oligometastatic oesophagogastric cancer according to multidisciplinary tumour boards in Europe

Kroese, Tiuri E.; Hillegersberg, Richard van; Schoppmann, Sebastian F.; Deseyne, Pieter; Nafteux, Philippe; Obermannová, Radka; Nordsmark, Marianne; Pfeiffer, Per; Hawkins, M.; Smyth, Elizabeth; Markar, Sheraz R.; Hanna, George B.; Cheong, Edward; Chaudry, Asif; Elme, Anneli; Adenis, Antoine; Piessen, Guillaume; Gani, Cihan; Bruns, Christiane; Moehler, Markus; Liakakos, Theodoros; Reynolds, John V.; Morganti, Alessio Giuseppe; Rosati, Riccardo; Castoro, Carlo; D’Ugo, Domenico; Roviello, Franco; Bencivenga, Maria; Manzoni, Giovanni De; Jeene, Paul M.; Sandick, Johanna W. van; Muijs, C.T.; Slingerland, Marije; Nieuwenhuijzen, Grard A. P.; Wijnhoven, Bas P. L.; Beerepoot, Laurens V.; Kołodziejczyk, Piotr; Polkowski, Wojciech; Alsina, María; Pera, Manuel; Fleitas-Kanonnikoff, Tania; Nilsson, Magnus; Gückenberger, Matthias; Mönig, Stefan P.; Wagner, Anna Dorothea; Wyrwicz, Lucjan; Berbée, Maaike; Gockel, Ines; Lordick, Florian; Griffiths, Ewen A.; Verheij, Marcel; Rossum, Peter S.N. van; Laarhoven, Hanneke W. M. van; Rosman, Camiel; Rutten, H.J.T.; Gootjes, Elske C.; Vonken, Francine E.M.; Dieren, Jolanda M. van; Vollebergh, Marieke A.; Sangen, Maurice van der; Creemers, Geert-Jan; Zander, Thomas; Schlößer, Hans; Cascinu, Stefano; Mazza, Elena; Nicoletti, Roberto; Damascelli, Anna; Slim, N.; Passoni, P.; Cossu, Andrea; Puccetti, Francesco; Barbieri, Lavinia; Fanti, Lorella; Azzolini, Francesco; Ventoruzzo, Federico; Szczepanik, Antoni M.; Visa, Laura; Reig, A.; Roques, Tom; Harrison, Mark; Ciseł, Bogumiła; Pikuła, Agnieszka; Skórzewska, Magdalena; Vanommeslaeghe, Hanne; Daele, Elke Van; Pattyn, Piet; Geboes, Karen; Callebout, Eduard; Ribeiro, Suzane; Duijvendijk, Peter van; Tromp, Cathrien; Sosef, Meindert N.; Warmerdam, Fabienne; Heisterkamp, Joos; Vera, Almudena; Jordá, E.; López-Mozos, Fernando; Fernández-Moreno, M.C.; Barrios-Carvajal, Maria; Huerta, Marisol; Steur, Wobbe de; Lips, Irene M.; Díez, Marc; Castro, Sandra; O’Neill, Robert; Holyoake, D.; Hacker, Ulrich; Denecke, Timm; Kuhnt, Thomas; Hoffmeister, Albrecht; Kluge, Regine; Bostel, Tilman; Grimminger, Peter; Jedlička, Václav; Křístek, Jan; Pospíšil, Petr; Mourrégot, A.; Maurin, Clotilde; Starling, Naureen; Chong, Irene

doi:10.1016/j.ejca.2021.11.032

Cited by 31 publications

(34 citation statements)

References 25 publications

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“…Therefore, the Oligo-Metastatic Esophagogastric Cancer (OMEC) consortium has initiated the OMEC project to come to a uniform definition. In the OMEC 1 study, the reporting on definitions of oligometastatic esophagogastric cancer in the literature was assessed [7] and in the OMEC-2 study, the multidisciplinary tumor boards of 50 esophagogastric cancer expert centers were asked to judge several real-life cases on the definition and treatment of OMD [8]. These results will be used for input into Delphi consensus rounds (OMEC-3) in order to establish a multidisciplinary European consensus statement on the definition and treatment of oligometastatic esophagogastric cancer (OMEC-4).…”

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confidence: 99%

Incidence and survival of patients with oligometastatic esophagogastric cancer: A multicenter cohort study

Kroese

Christ

Rossum

et al. 2022

Radiotherapy and Oncology

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confidence: 99%

Incidence and survival of patients with oligometastatic esophagogastric cancer: A multicenter cohort study

Kroese

Christ

Rossum

et al. 2022

Radiotherapy and Oncology

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“…OMEC is a consortium of 50 esophagogastric cancer expert centers in 15 countries in Europe and aims to achieve a multidisciplinary European consensus statement of the definition, diagnosis, and treatment of oligometastatic esophagogastric cancer. The OMEC project consists of 5 substudies, including a systematic review on definitions of OMD in esophagogastric cancer (OMEC-1) [12] , real-life clinical case discussions by 50 cancer expert centers asking for multidisciplinary team responses on definition and treatment (OMEC-2) [13] , and Delphi consensus process study through 2 online Delphi questionaire rounds and a consensus meeting (OMEC-3). Subsequently, the intended consensus statement for oligometastatic esophagogastric cancer (OMEC-4) is expected to pave the way for a clinical prospective study (OMEC-5).…”

Section: Discussionmentioning

confidence: 99%

Long-term survival after sequential local treatments for oligometastatic esophageal squamous cell carcinoma: A case report

Kroese

Rossum²,

Mook³

et al. 2022

International Journal of Surgery Case Reports

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“…The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to develop a multidisciplinary European consensus statement for the definition and strategy for treating oligometastatic esophagogastric cancer. 13 This consensus statement can aid clinicians in decision-making and is expected to result in a prospective European trial for these patients. DISCLOSURE There are no conflicts of interest.…”

Section: Futurementioning

confidence: 99%

ASO Author Reflections: Role of Local Treatment for Oligometastatic Esophagogastric Cancer

2022

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The concept of oligometastatic disease (OMD) implies that radical local treatment for OMD (e.g., metastasectomy or stereotactic body radiotherapy [SBRT]) can improve overall survival (OS). 1,2 This benefit of local treatment for OMD might be explained by the ''seed and soil'' hypothesis. 3 This hypothesis suggests that metastatic spread is the result of the interaction between tumor cells and the target organ. 3 According to this concept, certain tumors have a predisposition for a particular organ only because of this selective interaction. 3 This process might explain why patients experience a limited number of metastases in a certain organ only and why radical local treatment to that organ improves OS.Recent randomized controlled trials (RCTs) have indeed shown that local treatment of OMD improves survival outcomes for patients with prostate, colorectal, breast, and non-small cell lung cancer. 4-6 However, patients with esophagogastric cancer were not included in these RCTs. Therefore, the optimal management for patients with oligometastatic esophagogastric cancer is unclear.

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Definitions and treatment of oligometastatic oesophagogastric cancer according to multidisciplinary tumour boards in Europe

Cited by 31 publications

References 25 publications

Incidence and survival of patients with oligometastatic esophagogastric cancer: A multicenter cohort study

Incidence and survival of patients with oligometastatic esophagogastric cancer: A multicenter cohort study

Long-term survival after sequential local treatments for oligometastatic esophageal squamous cell carcinoma: A case report

ASO Author Reflections: Role of Local Treatment for Oligometastatic Esophagogastric Cancer

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