“…In that 1882 publication, Dr. Gee described a case series of nine children with “fitful or recurrent vomiting.” The publication of case studies over the more recent decades has established both an adult-onset variation of CVS (Abell, Kim, & Malagelada, 1988; Hermus et al, 2016; Keller, Desuki, Hobohm, Münzel, & Ostad, 2015; Prakash & Clouse, 1999; Shearer, Luthra, & Ford, 2018) and a probable toxicity-induced variant described as CHS (Allen, de Moore, Heddle, & Twartz, 2004; Schreck et al, 2018; Sontineni, Chaudhary, Sontineni, & Lanspa, 2009). The classic pediatric variety, with typical resolution in puberty and associations with migraine and anxiety, has been well characterized within the gastrointestinal (GI), neurological, and pediatric literature (Boronat, Ferreira-Maia, Matijasevich, & Wang, 2017; Irwin, Barmherzig, & Gelfand, 2017; Li et al, 2008; Li, Murray, Heitlinger, Robbins, & Hayes, 1998; Rashid et al, 2016; Romano, Dipasquale, Rybak, Comito, & Borrelli, 2018; Zeevenhooven, Koppen, & Benninga, 2017). Therefore, this article adds to the discussion by providing an evaluation of adult CVS and its potential relationship to CHS in the context of endocannabinoid dysregulation.…”