Definition of normothermic ischemia limits for kidney and pancreas grafts

Florack, G.; Sutherland, David E.R.; Ascherl, R.; Heil, John; Erhardt, W.; Najarían, John S.

doi:10.1016/0022-4804(86)90097-1

Cited by 35 publications

(8 citation statements)

References 12 publications

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“…5b and 6b). Although in our model the serum amylase and lipase are influenced by intraperitoneal resorption (exocrine secretions are drained freely into the peritoneum) and by the appearance of edema (accounting for relative obstruction of the exocrine secretions by increasing the interstitial pressure), the high serum levels of pancreatic enzymes indicate graft damage caused by combined WI and CI injury (28,29).…”

Section: Morphologic Examinationmentioning

confidence: 99%

Functional and structural integrity of porcine pancreatic grafts subjected to a period of warm ischemia and cold preservation with histidine-tryptophan-ketoglutarate (custodiol) or University of Wisconsin solution

Troisi

Meester²,

Broecke³

et al. 2003

Transplantation

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Section: Morphologic Examinationmentioning

confidence: 99%

Functional and structural integrity of porcine pancreatic grafts subjected to a period of warm ischemia and cold preservation with histidine-tryptophan-ketoglutarate (custodiol) or University of Wisconsin solution

Troisi

Meester²,

Broecke³

et al. 2003

Transplantation

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“…In general, a renal ischemic time of 60 min is safe; this is supported experimentally (11, 12) and in clinical studies (13, 14). Wahlberg et al (15) emphasized that the most important risk factor for allograft ischemic damage is the clamping time of the aorta proximal to the renal artery; they concluded that aortic clamping above the renal arteries for up to 50 min appears to be safe.…”

Section: Discussionmentioning

confidence: 81%

Abdominal Aortic Aneurysm Repair in Patient with a Renal Allograft: A Case Report

et al. 2009

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Renal transplant recipients requiring aortic reconstruction due to abdominal aortic aneurysm (AAA) pose a unique clinical problem. The concern during surgery is causing ischemic injury to the renal allograft. A variety of strategies for protection of the renal allograft during AAA intervention have been described including a temporary shunt, cold renal perfusion, extracorporeal bypass, general hypothermia, and endovascular stent-grafting. In addition, some investigators have reported no remarkable complications of the renal allograft without any specific measures. We treated a case of AAA in a patient with a renal allograft using a temporary aortofemoral shunt with good result. Since this technique is safe and effective, it should be considered in similar patients with AAA and previously placed renal allografts.

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“…It is one of the factors determining the structural and functional state of a collected organ and, consequently, its survival after transplantation. Each organ has a definite tolerance to warm ischemia; for example, the ischemia limit for the liver is less than 30 min and for the pancreas and kidneys less than 60 min (Florack et al, 1986;He et al, 2003He et al, , 2004. Retrieval of tissue Numerous (corresponding to 1 1) flattened cells with astrocyte-like morphology and weak expression of S100 were present in culture.…”

Section: Isolation and Culture Of Oecs From The Obmentioning

confidence: 97%

The olfactory bulb and olfactory mucosa obtained from human cadaver donors as a source of olfactory ensheathing cells

Międzybrodzki

Tabakow

Fortuna

et al. 2006

Glia

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During the last decade, olfactory ensheathing cells (OECs) have been successfully applied in multiple experimental approaches aimed to repair damaged mammalian spinal cord. Some of these experiments have consequently been translated into clinical trials. Finding a reliable source of human OECs that is easily accessible and can ensure a sufficient number of cells is a major prerequisite for conducting studies on OEC-mediated spinal cord regeneration. Here, we present a procedure for obtaining olfactory bulbs (OBs) and olfactory mucosa (OM) simultaneously from adult cadaver heart-beating donors for OEC isolation and analyze some of the factors that may condition successful OEC culture. We show that the results of OEC culture from OBs (10 cases) correlated significantly with warm ischemia time (WIT) as well as the initial viability of the isolated cells. Efficient OEC culture was possible when the WIT for the OB was up to 20 min. Brain damage, assessed by determination of S100B serum level, was not related to the success of OEC culture from the OB. Cadaver OM (7 cases) was shown to be a more reliable source of human OECs than the OB. In most of the examined cases the efficacy of culturing OECs from cadaver OM obtained even 180 min after cardiac arrest was comparable to that of living patients. The method of obtaining OBs and OM from cadavers enables the use of an alternative source of primary adult human OECs for further preclinical and clinical studies on their neurotrophic properties.

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Definition of normothermic ischemia limits for kidney and pancreas grafts

Cited by 35 publications

References 12 publications

Functional and structural integrity of porcine pancreatic grafts subjected to a period of warm ischemia and cold preservation with histidine-tryptophan-ketoglutarate (custodiol) or University of Wisconsin solution

Functional and structural integrity of porcine pancreatic grafts subjected to a period of warm ischemia and cold preservation with histidine-tryptophan-ketoglutarate (custodiol) or University of Wisconsin solution

Abdominal Aortic Aneurysm Repair in Patient with a Renal Allograft: A Case Report

The olfactory bulb and olfactory mucosa obtained from human cadaver donors as a source of olfactory ensheathing cells

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