Definition of metabolic syndrome in preadolescent girls

Carolyn, H.; Wang, Yun; Wilson, Darrell M.; Robinson, Thomas N.

doi:10.1016/j.jpeds.2006.01.048

Cited by 44 publications

(24 citation statements)

References 41 publications

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“…A low agreement was also observed in a sample of preadolescents girls between the definition adopted from the National Cholesterol Education Program Adult Treatment Panel III and the one adopted from the World Health Organisation. 50 The comparisons presented here apply different definitions to the same data such that the laboratory assay used does not affect comparability. This may not be the case when data from other studies using different assays are to be compared with our results.…”

Section: Idefics Monitoring Level Idefics Action Levelmentioning

confidence: 99%

Metabolic syndrome in young children: definitions and results of the IDEFICS study

et al. 2014

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on behalf of the IDEFICS consortium OBJECTIVE: To estimate the prevalence of the metabolic syndrome (MetS) using reference standards obtained in European children and to develop a quantitative MetS score and describe its distribution in children. DESIGN AND METHODS: Population-based survey in eight European countries, including 18 745 children 2.0 to 10.9 years, recruited during a second survey. Anthropometry (weight, height and waist circumference), blood pressure and serum-fasting triglycerides, HDL cholesterol, glucose and insulin were measured. We applied three widely accepted definitions of the pediatric MetS and we suggest a new definition, to guide pediatricians in decisions about close monitoring or even intervention (values of at least three of the MetS components exceeding the 90th or 95th percentile, respectively). We used a z-score standardisation to calculate a continuous score combining the MetS components. RESULTS: Among the various definitions of MetS, the highest prevalence (5.5%) was obtained with our new definition requiring close observation (monitoring level). Our more conservative definition, requiring pediatric intervention gives a prevalence of 1.8%. In general, prevalences were higher in girls than in boys. The prevalence of metabolic syndrome is highest among obese children. All definitions classify a small percentage of thin or normal weight children as being affected. The metabolic syndrome score shows a positive trend with age, particularly regarding the upper percentiles of the score. CONCLUSIONS: According to different definitions of pediatric MetS, a non-negligible proportion of mostly prepubertal children are classified as affected. We propose a new definition of MetS that should improve clinical guidance. The continuous score developed may also serve as a useful tool in pediatric obesity research. It has to be noted, however, that the proposed cutoffs are based on a statistical definition that does not yet allow to quantify the risk of subsequent disease.

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Section: Idefics Monitoring Level Idefics Action Levelmentioning

confidence: 99%

Metabolic syndrome in young children: definitions and results of the IDEFICS study

et al. 2014

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“…For example, using 2 different cutoff criteria in a single data set, a recent report determined prevalence rates of 15.3% versus 23.0% in girls. 18 An assessment of the MetS in 2430 children from the Third National Health and Nutrition Examination Survey (1988 -1994) reported a prevalence of 4%, but the prevalence in overweight children was 30%. 19 Using ATP III and World Health Organization criteria, a school-based study of 1513 North American adolescents found a 4.2% and 8.4% prevalence of MetS, respectively, 20 whereas a study of 965 Mexican children and adolescents found a 6.5% and 4.5% prevalence, respectively.…”

Section: T He Present Document Is An Update Of the 2003 Americanmentioning

confidence: 99%

Progress and Challenges in Metabolic Syndrome in Children and Adolescents

Steinberger¹,

Daniels²,

Eckel³

et al. 2009

Circulation

618

278

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“…16,17 Since publication of the first article on MetS in adolescents in 2003, 15 there has been growing interest in and movement toward therapeutic intervention for this syndrome in children and adolescents. 17,34,35 This drive toward treatment has been fueled, in part, by reports that rising rates of obesity and concomitant MetS would lead to "epidemics" of type 2 diabetes mellitus and early cardiovascular disease in the young. 16,36 Although these epidemics have not materialized, 37 the focus on intervention, which would include potential use of pharmacological agents, remains.…”

Section: Goodman Et Al Instability In Metabolic Syndromementioning

confidence: 99%

Instability in the Diagnosis of Metabolic Syndrome in Adolescents

et al. 2007

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Background-Factor analyses suggest that the structure underlying metabolic syndrome is similar in adolescents and adults. However, adolescence is a period of intense physiological change, and therefore stability of the underlying metabolic structure and clinical categorization based on metabolic risk is uncertain. Methods and Results-We analyzed data from 1098 participants in the Princeton School District Study, a school-based study begun in 2001-2002, who were followed up for 3 years. We performed factor analyses of 8 metabolic risks at baseline and follow-up to assess stability of factor patterns and clinical categorization of metabolic syndrome. Metabolic syndrome was defined using the current American Heart Association/National Heart, Lung, and Blood Institute definition for adults (AHA), a modified AHA definition used in prior pediatric metabolic syndrome studies (pediatric AHA), and the International Diabetes Federation (IDF) guidelines. We found that factor structures were essentially identical at both time points. However, clinical categorization was not stable. Approximately half of adolescents with baseline metabolic syndrome lost the diagnosis at follow-up regardless of the definitions used: pediatric AHAϭ56% (95% confidence interval [CI], 42% to 69%), AHAϭ49% (95% CI, 32% to 66%), IDFϭ53% (95% CI, 38% to 68%). In addition to loss of the diagnosis, new cases were identified. Cumulative incidence rates were as follows: pediatric AHAϭ3.8% (95% CI, 2.8% to 5.2%); AHAϭ4.4% (95% CI, 3.3% to 5.9%); IDFϭ5.2% (95% CI, 4.0% to 6.8%). Conclusions-During adolescence, metabolic risk factor clustering is consistent. However, marked instability exists in the categorical diagnosis of metabolic syndrome. This instability, which includes both gain and loss of the diagnosis, suggests that the syndrome has reduced clinical utility in adolescence and that metabolic syndrome-specific pharmacotherapy for youth may be premature.

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Definition of metabolic syndrome in preadolescent girls

Cited by 44 publications

References 41 publications

Metabolic syndrome in young children: definitions and results of the IDEFICS study

Metabolic syndrome in young children: definitions and results of the IDEFICS study

Progress and Challenges in Metabolic Syndrome in Children and Adolescents

Instability in the Diagnosis of Metabolic Syndrome in Adolescents

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