Definition of a new entity of malignant extragonadal germ cell tumors

Vanechten, J; Dejong, B; Sinke, Richard J.; Weghuis, D.E.M. Olde; Sleijfer, Dirk; Oosterhuis, J. Wolter

doi:10.1002/gcc.2870120103

Cited by 22 publications

(4 citation statements)

References 23 publications

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“…The most common chromosomal abnormality seen in teratomas is an isochromosome of the short arm of chromosome 12 [16]. An isochromosome is an abnormal chromosome with two identical arms due to the loss of one arm and duplication of the other.…”

Section: Chromosomal Abnormalitiesmentioning

confidence: 99%

Primary retroperitoneal teratomas: A review of the literature

Gatcombe

Assikis

Kooby

et al. 2004

Journal of Surgical Oncology

210

247

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Teratomas are uncommon neoplasms comprised of mixed dermal elements derived from the three germ cell layers. Historically, teratomas were attributed to demons, sexual misconduct, and abnormal fertilization. They attract attention because of their bizarre histology and gross appearance. While the majority of teratomas present congenitally in the sacrococcygeal region, within the ovaries of adolescent females and within the testes of young men, they have been identified throughout the body. Extragonadal teratomas tend to occur in midline structures as the anterior mediastinum, retroperitoneum, sacrococcygeal region, and pineal gland. Retroperitoneal teratomas represent only 1-11% of primary retroperitoneal tumors. Incidence is bimodal with peaks in the first 6 months of life and in early adulthood. Due to their location, they are usually identified only after they have grown to huge proportions. There is a 25% chance of malignancy. Surgical resection remains the mainstay of therapy and is required for definitive diagnosis. This article reviews the literature on the histopathology, classification, genetic abnormalities, and theories of origin of teratomas as well as the presentation, diagnosis, and management of retroperitoneal teratomas.

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Section: Chromosomal Abnormalitiesmentioning

confidence: 99%

Primary retroperitoneal teratomas: A review of the literature

Gatcombe

Assikis

Kooby

et al. 2004

Journal of Surgical Oncology

210

247

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“…These tumours are exclusively type II, and with rare exceptions are encountered in men. Although GCTs may rarely arise in the posterior mediastinum, 27 they are typically associated with the thymus gland in the anterior mediastinum 11 . It is commonly assumed that the reason for GCTs to develop in the mediastinum is because of erroneous migration of primordial germ cells en route to the gonads 19,20,28 .…”

Section: General Remarksmentioning

confidence: 99%

Tumours and tumour‐like conditions of the thymus other than thymoma; a practical approach

Bakker

Oosterhuis

2009

Histopathology

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Masses within the thymus and mediastinum are frequently biopsied to establish a diagnosis. The specimens sent for histopathological analysis are typically small (needle) biopsy specimens on which the pathologist is challenged to provide a classifying diagnosis. Despite the fact that the pathology of the anterior mediastinum is predominantly centred on the thymus and it thus might be expected that the range of possible diagnoses is limited, the list of disease entities is in fact extensive, encompassing hyperplastic conditions and both benign and malignant neoplasms. In addition to primary thymic epithelial tumours, a number of less common diseases typical for this location may be encountered, including extragonadal germ cell tumours, lymphomas, soft tissue tumours and a number of conditions which may simulate a tumour, such as cysts and inflammatory conditions. In this review, the disease entities that may be encountered in biopsy material from anterior mediastinal/thymic processes are discussed and an approach to tackle the differential diagnosis is provided.

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“…Therefore, we ini tiated the fine mapping of the t(5;ll)(q35;ql3) breakpoint. Because band llq l3 is involved in a variety of malignant disorders, including mantle cell lymphomas, squamous cell carcinomas, breast cancer, multiple endocrine neopla sia type 1, and extragonadal germ cell tumors [24][25][26][27][28][29][30], and because llq l3 is relatively well mapped [24,31,32], we selected this region for detailed analysis. To this end, fluo rescence in situ hybridization (FISH) with breakpoint re gion-specific probes was employed.…”

Section: Introductionmentioning

confidence: 99%

Fine Mapping of the Human Renal Oncocytoma-Associated Translocation (5;11)(q35;q13) Breakpoint

Sinke

Dijkhuizen

Janssen

et al. 1997

Cancer Genetics and Cytogenetics

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Recent cytogenetic analysis of a series of human renal oncocytomas revealed the presence of a recurring chromosomal translocation (5;ll)(q35;ql3) as sole anomaly in a subset of the tumors. The molecular characterization of this translocation was initiated using two primary t(5;ll)-positive renal oncocytomas and a panel of soma tic cell hybrids derived from one of these tumors, in conjunction with fluorescence in situ hybridization (FISH) and Southern blot analysis. The breakpoint in chromosome band llql3 could be located within a genomic interval of at maximum 400 Kb immediately centromeric to the BCLl locus.

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Definition of a new entity of malignant extragonadal germ cell tumors

Cited by 22 publications

References 23 publications

Primary retroperitoneal teratomas: A review of the literature

Primary retroperitoneal teratomas: A review of the literature

Tumours and tumour‐like conditions of the thymus other than thymoma; a practical approach

Fine Mapping of the Human Renal Oncocytoma-Associated Translocation (5;11)(q35;q13) Breakpoint

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