Definition and Multiple Factors of Recurrent Spontaneous Abortion

La, Xiaolin; Wang, Wen‐Juan; Zhang, Meng; Liang, Li

doi:10.1007/978-981-33-4187-6_11

Cited by 45 publications

(39 citation statements)

References 189 publications

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“…We then set out to explore deeper relationship between the serum transaminase levels and EPL. Serum transaminase levels, several etiologies of RSA, conception methods, autoimmunity and coagulation-related clinical indicators were included in Pearson correlation analyses 11 . The results showed that age[?…”

Section: Early Pregnancy Loss Was More Common In the Transaminase-ele...mentioning

confidence: 99%

Transaminase elevation during the first trimester and early pregnancy loss in patients with recurrent spontaneous abortion: a cross-sectional study

Zhang

et al. 2022

Preprint

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Objective: To investigate the association between transaminase elevation during the first trimester and early pregnancy loss (EPL) in patients with recurrent spontaneous abortion (RSA). Further, the contributing risk factors for transaminase elevation in early pregnancy in RSA patients were analyzed Design: Cross-sectional study Setting: China Population: RSA patients during the first trimester Methods: Patients were divided into EPL group and N-EPL group as well as transaminase-elevated group (TE group) and transaminase-normal group (TN group). The relationship between transaminase level and EPL and the risk factors of elevated transaminase were investigated via student’s t test, Pearson chi-square test and logistic regression analyses. Main outcome measure: The association between transaminase elevation and EPL and the risk factors for elevated transaminase. Results: Higher serum transaminase levels were observed in EPL group than in the N-EPL group (p <0.05). Comparing with TN group, EPL is more common in TE group (p =0.018). There is still a correlation between elevated transaminases and EPL in RSA patients after adjusting for covariates (AST: OR, 1.018; 95% CI, 1.007-1.029; p, 0.001; ALT: OR, 1.006; 95%CI, 1.001-1.011; p, 0.018). The higher the transaminases, the greater the likelihood of EPL (p <0.05). Multivariate regression analysis found that the use of IVIG was an independent risk factor for elevated transaminase in RSA patients (OR, 0.374; 95% CI, 0.162-0.864; p =0.021). Conclusion: Serum transaminase levels are significantly correlated with RSA early pregnancy loss. Moreover, medication use is significantly correlated with transaminase elevation in the first trimester in RSA patients, especially IVIG.

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Section: Early Pregnancy Loss Was More Common In the Transaminase-ele...mentioning

confidence: 99%

Transaminase elevation during the first trimester and early pregnancy loss in patients with recurrent spontaneous abortion: a cross-sectional study

Zhang

et al. 2022

Preprint

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“…Recent research suggests that blood flow through the uterine arteries controls how receptive the uterine lining is to embryo implantation. This suggests that improper blood flow through the uterus may be a contributing factor in spontaneous miscarriages and, more likely, in implantation failure [4] . Many researched recommend more studies for the purpose of better understanding the vascular alterations that accompany recurrent miscarriage and pinpointing the causes of uterine perfusion problems in these women [5] .…”

Section: Effect Of Low Dose Aspirin On Luteal Phase Uterine Artery Do...mentioning

confidence: 99%

Effect of low dose aspirin on luteal phase uterine artery Doppler indices in women with recurrent pregnancy loss

Mansour

Gebriel²,

Abdelmoaty³

2022

International Journal of Medical Arts

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Article informationBackground: The obstetrical difficulties associated with repeated miscarriages persist. It's associated with poor uterine blood flow, and vasodilators seem to stop miscarriages from happening again. Aim of the work:During the luteal phase, Doppler indices of the uterine artery were measured to see whether low-dose aspirin had any effect on recurrent miscarriage. Patients and methods: Patients experiencing recurrent pregnancy loss [RPL] were randomly assigned to one of two treatment groups in a randomized controlled trial [RCT]; Group A [Case Group]: subjects were those who had a history of two or more recurrent miscarriages and who were administered a modest dosage of Aspirin Group B [Control Group]: Subjects with a history of two or more consecutive miscarriages were not administered Aspirin. Studied Doppler indices included Systolic-to-diastolic ratios [S/D], resistance index [RI] and pulsatility indices [PI] Results: RI, PI, and S/D were significantly lower among group A group compared to group B group after treatment with aspirin in group A. Individuals who had had one or two prior miscarriages had the lowest uterine index values, although this difference was not statistically significant. Conclusion:Uterine blood flow was reduced during the luteal phase in those who had had repeated miscarriages. Aspirin, even at modest doses, increased uterine blood flow, and this effect was reversible, suggesting its potential therapeutic use.

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“…RSA affects approximately 2-5 % of women of childbearing age and results in marked psychological and mental trauma and economic burden. The causes include age, anatomical cacogenesis of uterus, chromosomal abnormality, inheritance, smoking and drinking, endocrine, placental abnormalities, infection, psychological factors, environmental pollution, and radiation, among others [4].…”

Section: Introductionmentioning

confidence: 99%

Alterations in meibomian gland characteristics and tear film-related parameters in patients with threatened abortion: a new diagnostic index

Wang

Kang

et al. 2023

Preprint

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Objective To analyze the alterations in ophthalmic parameters in patients with recurrent spontaneous abortion (RSA), and find the possible eye surface recognition site of threatened abortion (TA) patients. Methods Fifty-two patients with RSA (104 eyes) were recruited. Analyzers were used to examine the parameters of MG and tear film. The distribution of the MG grades of the patients and the correlation between the MG and tear film were analyzed; tear film rupture was used as the grading standard for the MG grade. Results The grade for MG loss in the patients increased with the grade for tear film rupture. MG length (L) and MG area ratio (GA), MG diameter (D) and MG tortuosity index (TI), MG diameter deformation index (DI) and TI were positively correlated. L and TI was negatively correlated. The tear film rupture area was mainly concentrated in the fifth ring and quadrants 3 and 4. The intersection area was mainly located in the fifth ring of sixth and seventh regions. Conclusion In RSA patients, tear film stability is greater when MG loss is farther from the pupil. The degree of gland distortion may be a new diagnostic index for gland variation, and the probability of gland variation in patients with larger meibomian gland area can decrease. The tear film rupture area was mainly concentrated in the fifth ring of the sixth and seventh regions of the pupil, which is expected to become the eye surface recognition site for women with TA.

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Definition and Multiple Factors of Recurrent Spontaneous Abortion

Cited by 45 publications

References 189 publications

Transaminase elevation during the first trimester and early pregnancy loss in patients with recurrent spontaneous abortion: a cross-sectional study

Transaminase elevation during the first trimester and early pregnancy loss in patients with recurrent spontaneous abortion: a cross-sectional study

Effect of low dose aspirin on luteal phase uterine artery Doppler indices in women with recurrent pregnancy loss

Alterations in meibomian gland characteristics and tear film-related parameters in patients with threatened abortion: a new diagnostic index

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