Definition and classification of erectile dysfunction: Report of the Nomenclature Committee of the International Society of Impotence Research

OBJECTIVE:To determine how well a single question of self-reported erectile dysfunction compares to a gold standard clinical urologic examination. DESIGN AND SETTING:Clinical validation study nested within the Massachusetts Male Aging Study (MMAS), which is an observational cohort study of aging and health in a population-based random sample of men.MEASUREMENT: During an in-person interview, men were asked to respond to a single-question self-report of erectile dysfunction. A subsample of MMAS participants was then subjected to a clinical urologic examination to obtain a clinical diagnosis of erectile dysfunction. PARTICIPANTS:One hundred thirty-nine men 55 to 85 years of age from the MMAS. RESULTS:Complete data were available from 137 men. Erectile dysfunction (ED) measured by self-report and independent urologic examination were strongly correlated (Spearman r =.80). Receiver operating curve analysis showed that the self-reported ED item accurately predicts the clinician-diagnosed ED (area under the curve [AUC] =0.888). Stratum-specific likelihood ratios (95% confidence intervals) for selfreports predicting the gold standard were: no ED =0.11 (0.06 to 0.22), minimal ED =1.48 (0.67 to 3.26), moderate ED =8.57 (1.21 to 60.65), and complete ED =12.69 (1.81 to 88.79). These data indicate that men diagnosed with ED by urologic examination can be distinguished from men not diagnosed with ED by urologic examination if the respondent self-reported no, moderate, or complete ED. CONCLUSION:Our single-question self-report accurately identifies men with clinically diagnosed ED, and may be useful as a referral screening tool in both research studies and general practice settings. (Table 1). We have previously shown that self-administration of this single question correlates well with the IIEF and the BMSFI, and that the proportion with missing data for the single question (9%) was similar to that for the BMSFI (8%) and lower than that for the IIEF (18% METHODSThe MMAS is an observational cohort study of health and aging in a population-based random sample of men. The design has been well-described elsewhere. 3,22,23 As part of the in-person interview, respondents were queried about erectile function with a single question. Table 1 presents the ED single question as it was presented to respondents in the MMAS. The substudy was described to all participants at the conclusion of the in-person interview, and each was offered the opportunity to participate. They were told that participation was strictly voluntary and independent of their participation in

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“…24 The components of this approach have been accepted by the U.S. 24,25 and international 26 urologic community.…”

Section: Methodsmentioning

confidence: 99%

The validity of a single-question self-report of erectile dysfunction

et al. 2005

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“…The cause of ED is confirmed as being psychogenic in origin on the basis of medical and sexual history, physical examination, hormonal studies (including total and bioavailable testosterone, prolactin), blood glucose, cholesterol and lipid levels, intracavernosal pharmacotesting with penile duplex ultrasonography, and psychological evaluation. 6 Neurological evaluation revealed no signs of depression or other psychoneurological diseases that could interfere with nocturnal penile tumescence and rigidity (NPTR) recordings.…”

Section: Methodsmentioning

confidence: 99%

Sildenafil citrate significantly improves nocturnal penile erections in sildenafil non-responding patients with psychogenic erectile dysfunction

2004

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“…4 We also studied a group of 5 normal, potent patients (aged 26 ± 42 y) without complaints of sexual dysfunction and without risk factors of erectile dysfunction. These volunteers followed the same indications as the other group.…”

Section: Methodsmentioning

confidence: 99%

Sildenafil improves nocturnal penile erections in organic impotence

et al. 2001

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We studied the effects of sildena®l on nocturnal penile erections. We prospectively evaluated 36 patients with organic or psychogenic impotence and 5 normal, potent men. All patients completed 3 sessions of consecutive nights using the RigiScan Plus device. The ®rst two nights the patients were asked to take placebo before the session and to take 50 mg of sildena®l before the third session. In the organic impotence group the use of sildena®l induced a signi®cant improvement in time of rigidity 60 ± 100%, rigidity and tumescence activity unit values and rigidity and tumescence activity unit values per hour in the tip and base. In the psychogenic impotence group it caused signi®cant improvement only in rigidity activity unit per hour in the tip. In the potent men, changes were statistically insigni®cant. Sildena®l improves nocturnal penile erectile activity in organic impotence. Our study shows that phosphodiesterase inhibitors can improve penile erections not induced by sexual stimulation.

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Definition and classification of erectile dysfunction: Report of the Nomenclature Committee of the International Society of Impotence Research

Cited by 142 publications

References 1 publication

The validity of a single-question self-report of erectile dysfunction

The validity of a single-question self-report of erectile dysfunction

Sildenafil citrate significantly improves nocturnal penile erections in sildenafil non-responding patients with psychogenic erectile dysfunction

Sildenafil improves nocturnal penile erections in organic impotence

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