Defining thresholds for critical ischemia by using near-infrared spectroscopy in the adult brain

Kirkpatrick, Peter J.; Lam, Joseph M.; Al-Rawi, Pippa G.; Śmielewski, Piotr; Czosnyka, Marek

doi:10.3171/jns.1998.89.3.0389

Cited by 98 publications

(54 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Accordingly, changes from the preclamp period rather than absolute values seem to be more important to predict the occurrence of cerebral ischemia. This is in agreement with findings reported by Kirkpatrick et al [22] who demonstrated that the percentage change in rSo 2 , rather than its absolute value, is strictly correlated to the percentage decrease in cerebral blood flow.…”

Section: Discussionsupporting

confidence: 93%

A clinical evaluation of near-infrared cerebral oximetry in the awake patient to monitor cerebral perfusion during carotid endarterectomy

Rigamonti

Scandroglio

Minicucci

et al. 2005

Journal of Clinical Anesthesia

122

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 93%

A clinical evaluation of near-infrared cerebral oximetry in the awake patient to monitor cerebral perfusion during carotid endarterectomy

Rigamonti

Scandroglio

Minicucci

et al. 2005

Journal of Clinical Anesthesia

122

View full text Add to dashboard Cite

“…A number of modalities have been introduced for detecting cerebral malperfusion during cardiovascular surgery or carotid artery surgery, including transcranial Doppler ultrasound [1][2][3] and near-infrared spectroscopy (NIRS) [1][2][3][4][5][6][7][8][9]. We have routinely used NIRS monitoring since 1998 and have recognized that the regional oxygen saturation (rSO2) promptly drops upon temporary circulatory arrest, and then recovers as systemic circulation resumes in patients undergoing aortic surgery with selective cerebral perfusion (SCP).…”

Section: Introductionmentioning

confidence: 99%

Near-infrared spectroscopy for monitoring cerebral ischemia during selective cerebral perfusion

Orihashi

Sueda

Okada

et al. 2004

European Journal of Cardio-Thoracic Surgery

122

View full text Add to dashboard Cite

show abstract

“…NIRS has been used to monitor patients with head injuries [2, 3], during cerebral thrombolysis [4, 5], cardiopulmonal bypass [6, 7], and carotid endarterectomy [8, 9, 10]. However, validity and clinical significance are judged controversially [11, 12, 13, 14, 15].…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Monitoring of Cerebral Oxygenation during Vasomotor Reactivity Tests by a New Near-Infrared Spectroscopy Device

Terborg¹,

Birkner²,

Schack³

et al. 2003

Cerebrovasc Dis

View full text Add to dashboard Cite

Background: Spatially resolved spectroscopy is a recently developed technique for noninvasive monitoring of cerebral tissue oxygenation using the photon diffusion theory. Methods: We studied this technique with a new, commercial near-infrared spectroscopy (NIRS) device during vasomotor reactivity tests in 28 healthy volunteers (mean age 31.0 years; SD 10.6 years) and compared it with values assessed by the modified Beer-Lambert law and indices from simultaneous transcranial Doppler sonography of both middle cerebral arteries. We measured O₂ reactivity as percentage change of cerebral blood flow velocity (CBFV), as absolute change in the concentrations (measured in µmol/l) of oxygenated (HbO₂), deoxygenated (Hb) and total hemoglobin (HbT), and as change in the tissue oxygenation index (TOI) during inhalation of 100% oxygen. CO₂ reactivity was calculated as percentage change of CBFV (NCR), as absolute change in the concentrations of HbO₂, Hb, and HbT (µmol/l), and as change in TOI (%) per 1% increase in end-tidal CO₂. Results: One hundred percent oxygen inhalation lead to a decrease in CBFV (mean ± SD: left –8.0 ± 7.0%, p = 0.000; right –9.6 ± 7.6%, p = 0.000), an increase in HbO₂ (0.99 ± 1.07 µmol/l), Hbdiff (2.23 ± 1.72 µmol/l), and TOI (3.1 ± 1.5%), and a decrease in Hb (–1.22 ± 0.74 µmol/l), significant from baseline values (p = 0.0000). CO₂ reactivity was: NCR left 25.4 ± 14.7%; NCR right 25.9 ± 13.4%; HbO₂ 1.99 ± 0.97 µmol/l; Hb –1.24 ± 0.81 µmol/l; HbT 0.81 ± 1.0 µmol/l, and TOI 3.7 ± 2.2%. O₂ reactivity in TCD did not correlate with NIRS reactivities (Pearson p > 0.05), but NCR did correlate with changes in HbO₂, Hb, and TOI (Pearson p < 0.01). TOI was closely related to indices derived from the Beer-Lambert law (Pearson p < 0.03), but not with mean arterial blood pressure or skin blood flow during vasomotor reactivity tests. Conclusion: Spatially resolved spectroscopy provides an encouraging, noninvasive new tool to study cerebral tissue oxygenation during vasomotor reactivity tests consistent with physiological changes.

show abstract

Defining thresholds for critical ischemia by using near-infrared spectroscopy in the adult brain

Abstract: Carotid endarterectomy provides a stable environment for exploring NIRS-quantified thresholds for SCI in the adult head.

Cited by 98 publications

References 24 publications

A clinical evaluation of near-infrared cerebral oximetry in the awake patient to monitor cerebral perfusion during carotid endarterectomy

A clinical evaluation of near-infrared cerebral oximetry in the awake patient to monitor cerebral perfusion during carotid endarterectomy

Near-infrared spectroscopy for monitoring cerebral ischemia during selective cerebral perfusion

Noninvasive Monitoring of Cerebral Oxygenation during Vasomotor Reactivity Tests by a New Near-Infrared Spectroscopy Device

Contact Info

Product

Resources

About