Defining the timing of respiratory syncytial virus (RSV) outbreaks: an epidemiological study

Terletskaia-Ladwig, Elena; Enders, Gisela; Schalasta, Gunnar; Enders, Martin

doi:10.1186/1471-2334-5-20

Cited by 69 publications

(58 citation statements)

References 18 publications

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“…RT-PCR detected RSV in 41.2% of our infants. RSV bronchiolitis followed the typical seasonal pattern with a peak incidence during the winter months (February 2005, February 2006 and December 2006) 21 22. After RSV, the other viruses most frequently detected among infants with acute bronchiolitis in our study were hBoV and RV.…”

Section: Discussionsupporting

confidence: 55%

Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants

Midulla

Scagnolari

Bonci

et al. 2009

Archives of Disease in Childhood

190

228

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Section: Discussionsupporting

confidence: 55%

Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants

Midulla

Scagnolari

Bonci

et al. 2009

Archives of Disease in Childhood

190

228

View full text Add to dashboard Cite

show abstract

“…Other European countries, such as Switzerland, Sweden, and Finland, observed a yearly varying pattern of early and late seasons, whereas early seasons are associated with high incidences and vice versa (10,41,53). Previous reports from Germany including regions around Kiel, Stuttgart, and Freiburg also described a biennial rhythm of severe early and weak late seasons (3,50,58). An explanation for the absence of the biennial pattern in our study might be due to missed cases Apart from that, we observed no frequency in severe or weak RSV seasons as described previously.…”

Section: Discussionmentioning

confidence: 93%

Genetic Variability of Group A Human Respiratory Syncytial Virus Strains Circulating in Germany from 1998 to 2007

2009

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The variability between respiratory syncytial virus (RSV) strains is one of the features of RSV infections that might contribute to the ability of the virus to infect people repeatedly and cause yearly outbreaks. To study the molecular epidemiology of RSV, more than 1,400 RSV isolates from human nasopharyngeal aspirates or nasal or throat swabs from patients with respiratory illness were identified and differentiated by TaqMan reverse transcription-PCR into groups A and B. RSV group A was dominant in seven out of nine epidemic seasons. Phylogenetic analysis revealed that RSV group A genotypes GA2 and GA5 circulated from 1998 to 2007. Genotype GA7 was present in only two seasons (1999 to 2000 and 2002 to 2003). Comparison of the synonymous mutation/nonsynonymous mutation ratios showed greater evidence for selection pressure for genotype GA2 (1.18) than for GA5 (4.34). Partial protein sequences were predicted to encode G proteins of 298 amino acids in length and in a few cases of G proteins of 297 amino acids in length. Amino acid analysis also revealed genotype-specific amino acid substitutions: two substitutions for genotype GA2, seven for GA5, and three for GA7. Two to four putative, genotype-specific N-linked glycosylation sites were determined. Predicted Oglycosylation sites included 22 to 34 residues. This study provides for the first time data on the circulation pattern of RSV group A genotypes and their molecular characterization in Germany during nine consecutive epidemic seasons.

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“…We speculate that the decrease in hospitalization rates observed in the registry may reflect year-to-year variability in RSV epidemiology across seasons and geographic regions. 28,29 Other potential sources of variation were changes in participating sites, physicians, and study populations, and disparity in hospital admission criteria and RSV testing practices over the four consecutive seasons. In the registry, the number of hospitalizations was not based on direct review of hospital discharge records, but rather on chart review in pediatricians' offices and ongoing contact with patient caretakers during the study period.…”

Section: Discussionmentioning

confidence: 99%

Prevention of hospitalization due to respiratory syncytial virus: results from the Palivizumab Outcomes Registry

Frogel

Nerwen

Cohen³

et al. 2008

J Perinatol

103

108

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Objective: The Palivizumab Outcomes Registry contains data on infants and young children who received palivizumab for the prevention of respiratory syncytial virus (RSV) that causes serious lower respiratory tract illness.Study Design: Prospective observational registry enrolling those who received X1 dose of palivizumab during any RSV season (2000 to 2004) at participating US sites.Result: Of 19 548 subjects enrolled, 40% were born before 32 weeks', 48% between 32 and 35 weeks' and 12% after 35 weeks' gestation. Risk factors included child-care attendance, prematurity, chronic lung disease (CLD) and congenital heart disease (CHD). The RSV hospitalization rate of palivizumab recipients was 1.3%. Gender, gestational age <32 weeks, CLD, CHD, congenital airway abnormality, severe neuromuscular disease, Medicaid insurance and >2 children in household were associated with significantly higher rates. Home-care prophylaxis with palivizumab was associated with reduced hospitalization rates.Conclusion: Data on the use of palivizumab prophylaxis in primarily high-risk infants confirm low RSV hospitalization rates.

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Defining the timing of respiratory syncytial virus (RSV) outbreaks: an epidemiological study

Cited by 69 publications

References 18 publications

Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants

Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants

Genetic Variability of Group A Human Respiratory Syncytial Virus Strains Circulating in Germany from 1998 to 2007

Prevention of hospitalization due to respiratory syncytial virus: results from the Palivizumab Outcomes Registry

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