Defining the Role of Surgery for Primary Gastrointestinal Tract Melanoma

Cheung, Michael C.; Pérez, Eduardo A.; Molina, Manuel A.; Jin, Xiaodong; Gutierrez, Juan C.; Franceschi, Dido; Livingstone, Alan S.; Koniaris, Leonidas G.

doi:10.1007/s11605-007-0417-3

Cited by 135 publications

(139 citation statements)

References 28 publications

(33 reference statements)

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“…Kimura et al (17) reported the use of endoscopic mucosal resection for the treatment of early PMME, and recorded no recurrence after 18 months. Consistent with this finding, Cheung et al (18) evaluated the Surveillance, Epidemiology and End Results database of primary and identified complete surgical resection as the only identifiable treatment strategy that significantly improved survival in PMME patients. Therefore, the present study proposes that the timely surgery received by the current patient was significantly associated with the outcome, as the patient remained in good condition 12 months after esophagectomy.…”

Section: Discussionmentioning

confidence: 79%

Primary malignant melanoma of the esophagus: A case report and review of the literature

2015

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Abstract. Primary malignant melanoma of the esophagus (PMME) is a rare malignancy and the prognosis is typically poor. There is currently a lack of appropriate treatment strategies and clear guidance. The current study presents the case of a 65-year-old female with a two-month history of progressive dysphagia, the investigations of which resulted in a diagnosis of PMME. The patient was treated with a radical transhiatal esophagectomy with subcarinal lymphadenectomy followed by combined chemoimmunotherapy. The patient remains alive with no evidence of tumor progression at the 12-month follow-up. The purpose of the present study was to report a new case and to review the recent relevant literature regarding the treatment of PMME.

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Section: Discussionmentioning

confidence: 79%

Primary malignant melanoma of the esophagus: A case report and review of the literature

2015

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“…In a review article, Chang et al analyzed 84,836 cases of melanoma (in the USA) recorded in the period from 1985 to 1994 and localized in the skin (91.2%), eyes (5.2%), mucosa (1.2%), and unknown primary localization (2.2%) ( Table 1) 26 . In the study by Cheung et al, there were 659 cases of melanoma of the gastrointestinal tract: 53.6% anorectal (anal 31.4%, and rectal 22.2%), 32.8% oropharyngeal, 5.9% esophageal, 2.7% of the stomach, 2.3% of the small intestine, 1.4% of the gallbladder, and 0.9% of the colon 27 . In the review article by Hicks and Flaitz, aggregated data are given from several articles related to melanomas of the mucosa of the head and neck, which include 703 cases of oral mucosa and 770 cases of sinonasal mucosa (Table 2) 4,26,27 .…”

Section: Discussionmentioning

confidence: 99%

“…Th ey are a sign of already advanced melanoma, and are often accompanied by metastases to cervical lymph nodes. Melanomas of the oral cavity are located in 80% of cases on the mucosa of the palate and gingiva, and in other parts of the oral cavity, e.g., buccal mucosa, lips, tongue, base of the mouth, and uvula in 20% of cases 4,26,27 . From 35% to 37% of patients in whom OM develops, have pre-existing benign melanomatosis of the oral mucosa 28 .…”

Section: Characteristics Of Oral Melanomasmentioning

confidence: 99%

Primary Oral Mucosal Melanomas – Two Case Reports and Comprehensive Literature Review

Topić

Masic

Radović

et al. 2017

acc

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SUMMARY -Oral melanoma (OM) occurs from activated or genetically altered epidermal melanocytes. Th ere is no scientifi c evidence that OM can be linked to physical, chemical and thermal irritation, or to other risk factors of the oral cavity. According to fi gures from various countries, OM accounts for 0.2% to 7.5% ( Japan) of all cases of melanoma of the skin and mucous membrane. Th e male to female ratio of OM is 2:1. About 80% of OMs are located in the mucosa of the palate and maxillary gingiva. Th is paper presents two cases of oral mucosal melanoma of the upper and lower lips in women aged 62 and 59 years. Diagnosis, diff erential diagnosis and therapy are reported.

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“…The data collected from large cancer registries provides insight into tumor behavior and allow us to examine outcomes from current treatment strategies. [13][14][15][16][17][18] Although this represents an excellent database for comparative outcomes analysis, it is not without limitations. Using area poverty as a proxy for SES may result in misclassification of some patients whose postal code does not accurately reflect the true income level of the individual.…”

Section: Discussionmentioning

confidence: 99%

African American and poor patients have a dramatically worse prognosis for head and neck cancer

Molina

Cheung

Pérez

et al. 2008

Cancer

Self Cite

196

256

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BACKGROUND.Differences in cancer survival based on race, ethnicity, and socioeconomic status (SES) are a major issue. To identify points of intervention and improve survival, the authors sought to determine the impact of race, ethnicity, and socioeconomic status for patients with cancers of the head and neck (HN).METHODS.HN cancer patients diagnosed between 1998 and 2002 were examined using a linked Florida Cancer Data System and Florida Agency for Health Care Administration data set.RESULTS.A total of 20,915 patients with HN cancers were identified, predominantly in the oral cavity and larynx. Overall, 72% of patients were male, 89.7% were white, 8.4% were African American (AA), and 10.6% were Hispanic. The median survival time (MST) was 37 months. MST varied significantly by race (white, 40 months vs AA, 21 months; P < .001), sex (men, 36 months vs women, 41 months; P = .001), and area poverty level (lowest, 27 months vs highest, 34 months; P < .0001). Only 32% of AA patients underwent surgery in comparison with 45% of white patients (P < .001). On multivariate analysis, independent predictors of poorer outcomes were race, poverty, age, sex, tumor site, stage, grade, treatment modality, and a history of smoking and alcohol consumption.CONCLUSIONS.Carcinomas of the HN have an overall high mortality with a disproportionate impact on AA patients and the poor. Dramatic disparities by race and SES are not explained completely by demographics, comorbid conditions, or undertreatment. Earlier diagnosis and greater access to surgery and adjuvant therapies in these patients would likely yield significant improvement in outcomes. Cancer 2008. © 2008 American Cancer Society.

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Defining the Role of Surgery for Primary Gastrointestinal Tract Melanoma

Abstract: PGIM occurs most often in the oral-nasopharynx and anal canal. Surgical extirpation is the only identifiable treatment modality that significantly improves survival.

Cited by 135 publications

References 28 publications

Primary malignant melanoma of the esophagus: A case report and review of the literature

Primary malignant melanoma of the esophagus: A case report and review of the literature

Primary Oral Mucosal Melanomas – Two Case Reports and Comprehensive Literature Review

African American and poor patients have a dramatically worse prognosis for head and neck cancer

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