Defining the risk of developing Grade 2 proctitis following 125I prostate brachytherapy using a rectal dose–volume histogram analysis

Snyder, Kurt M.; Stock, Richard G.; Hong, S.; Lo, Yeh-Chi; Stone, Nelson N.

doi:10.1016/s0360-3016(01)01442-0

Cited by 204 publications

(72 citation statements)

References 18 publications

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“…This is motivated by the difference in the importance of the prostatic and periprostatic tissue in various regions. For example, various clinical studies have shown that in LDR brachytherapy, overdosing the posterior region of the prostate results in rectal complications (Snyder et al, 2001). …”

Section: Evaluation Methodsmentioning

confidence: 99%

New Image-Based Techniques for Prostate Biopsy and Treatment

Moradi¹

2012

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE April 2012 REPORT TYPE Annual Summary DATES COVERED PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERUniversity of British Columbia Vancouver, CA V6T 1Z4 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTThis report details the research and training outcomes of a prostate cancer postdoctoral training award. The work resulted in technologies for segmentation, cancer detection, and brachytherapy seed detection that take advantage of ultrasound vibroelastography and ultrasound RF signals. In segmentation, we report a fully automatic algorithm that combines B-mode and elastography data within an active shape model approach. For cancer detection, we report the sensitivity of 75.5% for elastography in cancer detection. In brachytherapy seed detection and dosimetry, we showed that the use of raw RF ultrasound signals can result in partial detection of the seed clouds, sufficient for registration to C-arm fluoroscopy for the purpose of dosimetry. The results were published in form of five journal publications and six conference presentations in international journals and conferences. The PI attended nine conferences and meetings during the course of the award. SUBJECT TERMS IntroductionThis documents reports the accomplishments of the PI, Dr Mehdi Moradi, supported by the postdoctoral training Award W81XWH-10-1-0201, from April 1, 2010 to March 31, 2012. The progress on the specific task listed in the award will be listed. Since this is a training award, other achievements of the trainee during the award will be enumerated as well. The technology developed for vibroelastography was described in the annual report. We will focus on progress towards specific clinical outcomes and achievements of the trainee.The rationale of the proposal is that prostate tumors cannot be visualized in the ultrasound Bmode i...

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Section: Evaluation Methodsmentioning

confidence: 99%

New Image-Based Techniques for Prostate Biopsy and Treatment

Moradi¹

2012

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“…nė vienam ligoniui, tačiau šis dažnėjo didėjant tiesiosios žarnos apšvitinamam tūriui -esant V100 >2,3 cm 3 , spindulinis G2 proktitas nustatytas 25,5 proc. pacientų (43).…”

Section: Tiesiosios žArnos Pažeidimasunclassified

Review on the effectiveness of prostate cancer brachytherapy

Inčiūra¹,

Jarusevicus²,

Vaičiūnas³

et al. 2009

Medicina

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“…The cumulative incidence of symptomatic radiation colitis is reported to be 10% to 30% for grade 1 or 2 colitis with mild symptoms, and 2% to 3% for grade 3 or 4 colitis with moderate to severe symptoms ( Table 1 ) [4][5][6][7][8]. However, the incidence of asymptomatic radiation colitis (microscopic or macroscopic changes without symptoms) is much higher, reported to be about 80% [ 3 , 9 ].…”

Section: Epidemiologymentioning

confidence: 99%

“…For prostate cancer, for example, about 65 to 75 Gy is delivered via external beam radiotherapy, but about 160 Gy can be delivered via brachytherapy [ 8 ]. The risk of radiotoxicity with brachytherapy is directly related to the volume of normal tissue irradiated.…”

Section: Preventionmentioning

confidence: 99%

“…Brachytherapy for prostate cancer causes mild radiation proctopathy in 8% to 13% of patients. However, this rate increases as the volume of rectum receiving the prescribed dose increases, from 0% for ≤ 0.8 mL of tissue to 25% for > 2.3 mL, suggesting that slight increases in the volume of tissue exposed signifi cantly increase the risk of proctopathy [ 8 ].…”

Section: Preventionmentioning

confidence: 99%

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Approaches to the prevention and management of radiation colitis

Qadeer¹,

Vargo

2008

Curr Gastroenterol Rep

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Radiation colitis refers to the characteristic changes in the mucosa of the colon and rectum secondary to pelvic radiation. Based on the interval from radiation to mucosal changes or symptoms, there are two well-defined forms of radiation colitis: acute, manifested by mucosal sloughing causing diarrhea, mucus discharge, and tenesmus; and chronic, characterized by obstructed defecation or ischemia of the mucosa due to obliterative endarteritis and resulting in mucosal telangiectasias, mucosal pallor, and friability causing rectal bleeding. Up to 25% of all patients receiving pelvic radiation develop mild symptoms, and 2% to 3% develop moderate to severe symptoms. Radiation colitis can be difficult to treat in some patients. There are several options for treating its symptoms. Argon plasma coagulation is the most common method of treating telangiectasias. Topical formaldehyde has also been used for distal telangiectasias. Obstructed defecation caused by radiation strictures (which are very fibrotic) usually can be treated successfully with stool softeners, colonic dilation, or steroid injection. Surgery should be avoided if possible because of its technical difficulty and the high incidence of postoperative complications such as anastomotic leak and fistula formation. New advances in radiation delivery techniques (eg, intensity-modulated radiation therapy) using specialized computer algorithms and medications such as amifostine may decrease the incidence of radiation colitis.

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Defining the risk of developing Grade 2 proctitis following 125I prostate brachytherapy using a rectal dose–volume histogram analysis

Cited by 204 publications

References 18 publications

New Image-Based Techniques for Prostate Biopsy and Treatment

New Image-Based Techniques for Prostate Biopsy and Treatment

Review on the effectiveness of prostate cancer brachytherapy

Approaches to the prevention and management of radiation colitis

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