Defining the Pros and Cons of AIS Surgery: Bringing Truth to the Neurosurgery Community and the Public

Zhang, Jun; Ma, Chi-Jiao; Liu, Zhi-Heng; Wang, Hai-Qiang

doi:10.1016/j.wneu.2018.01.209

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…It can be hard for the medical community to design and conduct studies to validate previous reports. Prior studies have presented the evidence on cancer and mortality risks of young scoliosis patients from cumulative radiographic radiation (spinal radiographs) [18] and tentatively proposed low radiation X-ray methodology [19], focusing on the issue dynamically with the medical community [20][21][22][23][24] with the aims for benefiting global patients and the public. Consequently, this work aims to evaluate whether adult CT scan exposure can increase the risks of cancer during the follow-up observation, based on systematic review and meta-analysis of global observational studies.…”

Section: Introductionmentioning

confidence: 99%

CT Scans and Cancer Risks: A Systematic Review and Dose-response Meta-analysis

Cao

Hua

et al. 2022

BMC Cancer

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Background There is still uncertainty on whether ionizing radiation from CT scans can increase the risks of cancer. This study aimed to identify the association of cumulative ionizing radiation from CT scans with pertaining cancer risks in adults. Methods Five databases were searched from their inception to November 15, 2020. Observational studies reporting cancer risks from CT scans in adults were included. The main outcome included quantified cancer risks as cancer case numbers in exposed/unexposed adult participants with unified converted measures to odds ratio (OR) for relative risk, hazard ratio. Global background radiation (2.4 mSv per year) was used as control for lifetime attribution risk (LAR), with the same period from incubation after exposure until survival to 100 years. Results 25 studies were included with a sum of 111,649,943 participants (mean age: 45.37 years, 83.4% women), comprising 2,049,943 actual participants from 6 studies with an average follow-up period as 30.1 years (range, 5 to 80 years); 109,600,000 participants from 19 studies using LAR. The cancer risks for adults following CT scans were inordinately increased (LAR adults, OR, 10.00 [95% CI, 5.87 to 17.05]; actual adults, OR, 1.17 [95%CI, 0.89 to 1.55]; combined, OR, 5.89 [95%CI, 3.46 to 10.35]). Moreover, cancer risks elevated with increase of radiation dose (OR, 33.31 [95% CI, 21.33 to 52.02]), and multiple CT scan sites (OR, 14.08 [95% CI, 6.60 to 30.05]). The risk of solid malignancy was higher than leukemia. Notably, there were no significant differences for age, gender, country, continent, study quality and studying time phrases. Conclusions Based on 111.6 million adult participants from 3 continents (Asia, Europe and America), this meta-analysis identifies an inordinately increase in cancer risks from CT scans for adults. Moreover, the cancer risks were positively correlated with radiation dose and CT sites. The meta-analysis highlights the awareness of potential cancer risks of CT scans as well as more reasonable methodology to quantify cancer risks in terms of life expectancy as 100 years for LAR. Prospero trial registration number CRD42019133487.

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