Defining the optimal threshold and prognostic utility of pre-treatment hemoglobin level as a biomarker for survival outcomes in head and neck cancer patients receiving chemoradiation

Jun, Sung; Yu, Han; Khan, Michael; Yu, Brian; Santhosh, Sharon; Chatterjee, Udit; Gill, J.S.; Iovoli, Austin J.; Farrugia, Mark; Wooten, Kimberly; Gupta, Vishal; McSpadden, Ryan; Kuriakose, Moni Abraham; Markiewicz, Michael R.; Al-Afif, Ayham; Hicks, Wesley L.; Platek, Mary E.; Seshadri, Mukund; Ray, Andrew D.; Repasky, Elizabeth A.; Singh, Anurag K.

doi:10.1016/j.oraloncology.2022.106054

Cited by 5 publications

(2 citation statements)

References 41 publications

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“…A meta-analysis of 5782 patients with metastatic hormone-sensitive prostate cancer cancers showed that low Hb levels were associated with an increased risk of cancer-specific mortality, biochemical recurrence, and disease progression 28 . In patients with head and neck cancers treated with chemoradiation, pretreatment Hb below 114 g/l was identified as an independent poor prognostic factor and considered as a biomarker to predict survival outcomes 29 . Similar results were observed in our study.…”

Section: Discussionmentioning

confidence: 99%

Analysis of prognostic factors and establishment of prognostic model for primary mediastinal germ cell tumors: a case controlled study

Leng

Cui

Mai

et al. 2023

International Journal of Surgery

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Background: The overall prognosis of primary mediastinal germ cell tumors (PMGCTs) is poor and the associated prognostic factors are not fully understood. Our goal was to investigate the prognostic factors of PMGCTs and to develop a validated prognostic prediction model. Materials and Methods: A total of 114 PMGCTs with specific pathological types were included in this study. Clinicopathological characteristics of nonseminomatous PMGCTs and mediastinal seminomas were compared using the χ 2 or Fisher’s exact test. Independent prognostic factors of nonseminomatous PMGCTs screened using the univariate and multivariate Cox regression analysis were then used to generate a nomogram. The predictive performance of the nomogram was evaluated using the concordance index, decision curve, and the area under the receiver operating characteristic curve (AUC) and validated by bootstrap resampling. The Kaplan–Meier curves of independent prognostic factors were analyzed. Results: This study included 71 cases of nonseminomatous PMGCTs and 43 cases of mediastinal seminomas. The 3-year overall survival rates for nonseminomatous PMGCTs and mediastinal seminomas patients were 54.5 and 97.4%, respectively. The overall survival prognostic nomogram for nonseminomatous PMGCTs was established by integrating independent prognostic factors, including the Moran-Suster stage, white blood cell, hemoglobin, and platelet-lymphocyte ratio. The nomogram demonstrated good performance with a concordance index of 0.760 and the 1-year and 3-year AUC values of 0.821 and 0.833, respectively. These values were better than those of the Moran-Suster stage system. The bootstrap validation had an AUC of 0.820 (0.724–0.915) and showed a well-fitting calibration curve. Besides, patients with mediastinal seminomas showed favorable clinical outcomes and all the nine patients received neoadjuvant therapy and postoperative surgery achieved pathological complete response. Conclusion: A nomogram based on staging and blood routine examination results was established to accurately and consistently predict the prognosis of patients with nonseminomatous PMGCTs.

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Section: Discussionmentioning

confidence: 99%

Analysis of prognostic factors and establishment of prognostic model for primary mediastinal germ cell tumors: a case controlled study

Leng

Cui

Mai

et al. 2023

International Journal of Surgery

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“…Multiple authors have shown how patient variables such as age and comorbidities can influence outcomes [1,2]. But interestingly, there has been an increasing interest in using peripheral blood factors such as leukocytes, albumin or hemoglobin as surrogates of the host status in head and neck cancer patients [3–9,10 ▪▪ ,11 ▪▪ ,12,13 ▪▪ ,14–22]. Generally, these variables are gathered prior to treatment initiation.…”

Section: Introductionmentioning

confidence: 99%

Host-related indexes in head and neck cancer

Valero,

León,

Quer

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of review Peripheral blood host-related indexes have been widely studied in cancer patients. Several authors have shown the prognostic capacity of these indexes in head and neck cancer. Therefore, there has been an increasing interest in this topic recently. Recent findings The main variables analyzed and used to create these host-related indexes are peripheral blood leukocytes – including neutrophils, monocytes and lymphocytes – albumin and hemoglobin levels. Other factors with proven prognostic capacity in some studies are: platelets, C-reactive protein, and BMI. Among all the combined indexes, the neutrophil-to-lymphocyte ratio has been the most accepted and used worldwide. Nonetheless, there are other indexes which group multiple of these factors that have shown better prognostic capacity, and are promising in the near future. Summary Host-related indexes are ideal biomarkers to be used on our daily-basis. There is enough evidence to start considering them when assessing patients with head and neck cancer.

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Development and validation of nomogram models for predicting postoperative prognosis of early-stage laryngeal squamous cell carcinoma

Juan,

Jiali,

Ziqi

et al. 2024

Current Problems in Cancer

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Defining the optimal threshold and prognostic utility of pre-treatment hemoglobin level as a biomarker for survival outcomes in head and neck cancer patients receiving chemoradiation

Cited by 5 publications

References 41 publications

Analysis of prognostic factors and establishment of prognostic model for primary mediastinal germ cell tumors: a case controlled study

Analysis of prognostic factors and establishment of prognostic model for primary mediastinal germ cell tumors: a case controlled study

Host-related indexes in head and neck cancer

Development and validation of nomogram models for predicting postoperative prognosis of early-stage laryngeal squamous cell carcinoma

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