Defining the Heterogeneity of Sleep Apnea Syndrome: A Cluster Analysis With Implications for Patient Management

Romero-Peralta, Sofía; García‐Río, Francisco; Barrio, Pilar Resano; Viejo-Ayuso, Esther; Izquierdo, José Luis; Sabroso, Rodrigo; Naval, Jorge Castelao; Francés, J. Fernández; Mediano, Olga

doi:10.1016/j.arbres.2021.02.022

Cited by 16 publications

(6 citation statements)

References 36 publications

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“…This path towards personalized medicine has had its advances and applications in adults, but it has not been replicated in the same way in children. It is known that groups of patients with similar characteristics can benefit from specific diagnostic and therapeutic management [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Treatment of Sleep Apnea in Children: A Future Perspective Is Needed

Solano-Pérez,

Coso,

Castillo-García

et al. 2023

Biomedicines

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Obstructive sleep apnea (OSA) in children is a prevalent, but still, today, underdiagnosed illness, which consists of repetitive episodes of upper airway obstruction during sleep with important repercussions for sleep quality. OSA has relevant consequences in the pediatric population, mainly in the metabolic, cardiovascular (CV), and neurological spheres. However, contrary to adults, advances in diagnostic and therapeutic management have been scarce in the last few years despite the increasing scientific evidence of the deleterious consequences of pediatric OSA. The problem of underdiagnosis and the lack of response to treatment in some groups make an update to the management of OSA in children necessary. Probably, the heterogeneity of OSA is not well represented by the classical clinical presentation and severity parameters (apnea/hypopnea index (AHI)), and new strategies are required. A specific and consensus definition should be established. Additionally, the role of simplified methods in the diagnosis algorithm should be considered. Finally, the search for new biomarkers for risk stratification is needed in this population. In conclusion, new paradigms based on personalized medicine should be implemented in this population.

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Section: Discussionmentioning

confidence: 99%

Diagnosis and Treatment of Sleep Apnea in Children: A Future Perspective Is Needed

Solano-Pérez,

Coso,

Castillo-García

et al. 2023

Biomedicines

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“…Obstructive sleep apnoea (OSA) is a heterogeneous disease [2], affecting more than one billion people worldwide [3]. It is defined as the existence of total or partial cessation of breathing (apnoea or hypopnoea) lasting at least 10 s, with a frequency of at least five of these respiratory events during sleep per nightly recording hour [4,5].…”

Section: T He Latest European Society Of Hypertension (Esh)mentioning

confidence: 99%

Nocturnal hypertension phenotypes and obstructive sleep apnoea

Oscullo,

Gomez-Olivas,

Martínez-García

2023

Journal of Hypertension

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“…Although individual variations in sleep patterns have been known for a long time from last century 12 , the exploration of such differences has predominantly relied on behavioural sleep indicators. Notably, studies have illuminated a landscape of sleep phenotypes that varied among the elderly 13 and distinct subtypes among patients with sleep disorders 14, 15 . However, these investigations often lack the integration of objective neurobiological markers, potentially hindering a comprehensive and deeper understanding of overall sleep patterns.…”

Section: Introductionmentioning

confidence: 99%

Neural correlates of device-based sleep characteristics in adolescents

Ma,

Sahakian,

Zhang

et al. 2024

Preprint

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Understanding the brain mechanisms underlying objective sleep patterns in adolescents and their implications for psychophysiological development is a complex challenge. Here, we applied sparse canonical correlation (sCCA) analysis on 3300 adolescents from Adolescent Brain Cognitive Development (ABCD) study, integrating extensive device-based sleep characteristics and multimodal imaging data. We revealed two sleep-brain dimensions: one characterized by later being asleep and shorter duration, linked to decreased subcortical-cortical network functional connectivities; the other showed higher heart rate and shorter light sleep duration, associated with lower brain volumes and decreased functional connectivities. Hierarchical clustering based on brain dimension associated with sleep characteristics revealed three biotypes of adolescents, marked by unique sleep profiles: biotype 1 exhibited delayed and shorter sleep, coupled with higher heart rate during sleep; biotype 3 with earlier and longer sleep, accompanied by lower heart rate; and biotype 2 with intermediate pattern. This biotypic differences also extended to cognition, academic attainment, brain structure and function in a gradient order. Longitudinal analysis demonstrated consistent biotypic differences from ages 9 to14, highlighting enduring cognitive and academic advantages in biotype3. The linked sleep-brain dimensions and the associated biotypes were well replicated in a longitudinal sample of 1271 individuals. Collectively, our novel findings delineate a linkage between objective sleep characteristics and developing brain in adolescents, underscoring their significance in cognitive development and academic attainment, which could serve as references for individuals with sleep difficulties and offer insights for optimizing sleep routines to enhance better cognitive development and school achievement.

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Defining the Heterogeneity of Sleep Apnea Syndrome: A Cluster Analysis With Implications for Patient Management

Cited by 16 publications

References 36 publications

Diagnosis and Treatment of Sleep Apnea in Children: A Future Perspective Is Needed

Diagnosis and Treatment of Sleep Apnea in Children: A Future Perspective Is Needed

Nocturnal hypertension phenotypes and obstructive sleep apnoea

Neural correlates of device-based sleep characteristics in adolescents

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