Defining the Boundaries of Development with Plasticity

Nicoglou, Antonine

doi:10.1007/s13752-011-0003-5

Cited by 13 publications

(6 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, geneticists and biologists have always been aware that the unidirectional central dogma of genetics cannot explain certain phenomena. Philosophers of biology have reflected extensively on how plasticity, the ability of organisms to adapt flexibly to environmental change, affects the nature-nurture distinction (West-Eberhard, 1989;Bateson and Gluckman, 2011;Nicoglou, 2011;Baedke, 2019). Findings in epigenetics, as well as other observations in biology, appear to challenge the idea that human norms can be understood apart from an individual's environmental context (Oyama, 2000;Keller, 2010).…”

Section: Epigenetic Responsibilitymentioning

confidence: 99%

Epigenetics and Responsibility

2024

View full text Add to dashboard Cite

EPDF and EPUB available Open Access under CC-BY-NC-ND licence. This volume brings together an international team of contributors to provide a much-needed examination of climate litigation in Africa. The book outlines how climate litigation in Africa is distinct as well as pinpointing where it connects with the global conversation. Chapters engage with crucial themes such as human rights approaches to climate governance, corporate liability and the role of gender in climate litigation.

show abstract

Section: Epigenetic Responsibilitymentioning

confidence: 99%

Epigenetics and Responsibility

2024

View full text Add to dashboard Cite

show abstract

“…However, geneticists and biologists have always been aware that this unidirectional model cannot explain certain phenomena. Philosophers of biology have already reflected extensively on how plasticity, the ability of organisms to adapt flexibly to environmental change, affects the nature–nurture distinction . Observations in biology seem to challenge the idea that human norms can be understood apart from an individual's environmental context.…”

Section: Dynamic Conceptions and Their Ethical Implicationsmentioning

confidence: 99%

“…Philosophers of biology have already reflected extensively on how plasticity, the ability of organisms to adapt flexibly to environmental change, affects the nature-nurture distinction. 37 Observations in biology seem to challenge the idea that human norms can be understood apart from an individual's environmental context. For example, it is suggested that human organisms are the result of the whole organism-environment system that supports human development.…”

Section: Dynamic Conceptions and Their Ethical Implicationsmentioning

confidence: 99%

The many meanings of autism: conceptual and ethical reflections

Hens

2019

Develop Med Child Neuro

View full text Add to dashboard Cite

Autism is a polysemous concept. It is defined as a neurodevelopmental disorder that is diagnosed based on an assessment of behaviour and dysfunction. Autism also refers to a specific way of information or sensorial processing. For those diagnosed with autism, it is a real and shared experience. In this paper, I sketch the moral work that biological conceptions of autism perform. They help to conceptualize the diagnosis and associated challenges as real and they remove some of the blame from the diagnosed person and/or their parents. But such approaches also risk neglecting the role of behaviour as a meaningful reaction to experiences. In thinking about the ethics of autism research, diagnosis of autism, and autism care, the recent findings of epigenetics and systems biology may help us overcome the dichotomy between biology and psyche, and point the way to a more nuanced and ethical view. What this paper adds The meaning of ‘autism’ has different layers and as such autism is a polysemous concept. The lived experience of autistic people matters in research.

show abstract

“…Biologists are increasingly aware about the importance of linking development with phenotypic plasticity because environmentally induced phenotypes require time to form and build (Nicoglou ). Compared to the study of conventional static traits, more sophisticated mathematical and statistical tools are entailed for modeling the phenotypic plasticity of developmental trajectory.…”

Section: Synthesizing Developmental Plasticity and Omicsmentioning

confidence: 99%

Modeling Phenotypic Plasticity in Growth Trajectories: A Statistical Framework

Wang

Pang

et al. 2013

Evolution

View full text Add to dashboard Cite

Phenotypic plasticity, that is multiple phenotypes produced by a single genotype in response to environmental change, has been thought to play an important role in evolution and speciation. Historically, knowledge about phenotypic plasticity has resulted from the analysis of static traits measured at a single time point. New insight into the adaptive nature of plasticity can be gained by an understanding of how organisms alter their developmental processes in a range of environments. Recent advances in statistical modeling of functional data and developmental genetics allow us to construct a dynamic framework of plastic response in developmental form and pattern. Under this framework, development, genetics, and evolution can be synthesized through statistical bridges to better address how evolution results from phenotypic variation in the process of development via genetic alterations. K E Y W O R D S :Developmental trajectory, dynamic modeling, functional mapping, logistic growth curve, phenotypic plasticity.The capacity of an organism to alter its phenotypes in response to changing environment is known as phenotypic plasticity (Schlichting 1986;Sultan 2000). Because of its central role in evolution and speciation, an explosion of interest in studying the causes and consequences of this phenomenon has been enthused for over a century (Baldwin 1896;Waddington 1942;Scheiner 1993;Wu 1998;Agraval 2001;Pigliucci 2005;West-Eberhard 2005;Fusco and Minelli 2010;Nicotra et al. 2010;Pfennig et al. 2010; Sultan 2010;Beldade et al. 2011;Sommer and Ogawa 2011). Recently, mounting recognition has been gained for the fact that phenotypic plasticity may make an important contribution to the occurrence of complex human diseases (Bateson et al. 2004;Feinberg 2007;Burdge and Lillycrop 2010;Hochberg et al. 2011) and the response of biodiversity to climate change (Nicotra * These authors contributed equally to this work. et al. 2010), stimulating the mechanistic study of plastic changes at the molecular and pathway level (Gilbert and Epel 2009).The phenotypic plasticity of an organism arises from its genotype through programmed change in gene expression (Lewontin 2000;West-Eberhard 2005;Beldade et al. 2011). It has become increasingly clear that phenotypic plasticity is not only regulated by environmental factors, but also largely determined by endocrine hormones and epigenetic methylation that mediate various biological functions during development (Richards 2008;Sommer and Ogawa 2011). An emerging conceptual framework for studying phenotypic plasticity is to integrate it with development by viewing the phenotype as the outcome of complex synergistic developmental systems (Sultan 2000;Dmitriew et al. 2010;Love 2010;Beldade et al. 2011; Parsons et al. 2011). Fusco andMinelli (2010) assessed the value of taking the phenotypic plasticity of developmental processes into the picture to account for the evolution of life cycle. P E R S P E C T I V EUnlike static phenotypes at single time points, the phenotypic plasticity of development ...

show abstract

Defining the Boundaries of Development with Plasticity

Cited by 13 publications

References 52 publications

Epigenetics and Responsibility

Epigenetics and Responsibility

The many meanings of autism: conceptual and ethical reflections

Modeling Phenotypic Plasticity in Growth Trajectories: A Statistical Framework

Contact Info

Product

Resources

About