Defining skeletal muscle resident progenitors and their cell fate potentials

Pannérec, Alice; Formicola, Luigi; Besson, V.; Marazzi, Giovanna; Sassoon, David

doi:10.1242/dev.089326

Cited by 129 publications

(149 citation statements)

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“…+ Cells Are Present in Perivascular and Parenchymal Zones, Express Progenitor and Pericyte Markers, and Differentiate Into SMC PW1 expression was found to identify adult stem and progenitor cells in multiple organs 14,15,20 although previous studies did not report on the expression in the lung. PW1 protein expression was detected by immunofluorescence in cells located in parenchymal and perivascular spaces, near small nonmuscularized and muscularized vessels ( Figure 1A and 1B).…”

Section: Mouse Pulmonary Pw1mentioning

confidence: 95%

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Resident PW1 ⁺ Progenitor Cells Participate in Vascular Remodeling During Pulmonary Arterial Hypertension

Dierick

Héry

Hoareau

et al. 2016

Circulation Research

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Rationale: Pulmonary arterial hypertension is characterized by vascular remodeling and neomuscularization. PW1 + progenitor cells can differentiate into smooth muscle cells (SMCs) in vitro. Objective: To determine the role of pulmonary PW1 + progenitor cells in vascular remodeling characteristic of pulmonary arterial hypertension. Methods and Results: We investigated their contribution during chronic hypoxia–induced vascular remodeling in Pw1 nLacZ+/− mouse expressing β-galactosidase in PW1 + cells and in differentiated cells derived from PW1 + cells. PW1 + progenitor cells are present in the perivascular zone in rodent and human control lungs. Using progenitor markers, 3 distinct myogenic PW1 + cell populations were isolated from the mouse lung of which 2 were significantly increased after 4 days of chronic hypoxia. The number of proliferating pulmonary PW1 + cells and the proportion of β-gal + vascular SMC were increased, indicating a recruitment of PW1 + cells and their differentiation into vascular SMC during early chronic hypoxia–induced neomuscularization. CXCR4 inhibition using AMD3100 prevented PW1 + cells differentiation into SMC but did not inhibit their proliferation. Bone marrow transplantation experiments showed that the newly formed β-gal + SMC were not derived from circulating bone marrow–derived PW1 + progenitor cells, confirming a resident origin of the recruited PW1 + cells. The number of pulmonary PW1 + cells was also increased in rats after monocrotaline injection. In lung from pulmonary arterial hypertension patients, PW1-expressing cells were observed in large numbers in remodeled vascular structures. Conclusions: These results demonstrate the existence of a novel population of resident SMC progenitor cells expressing PW1 and participating in pulmonary hypertension–associated vascular remodeling.

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Section: Mouse Pulmonary Pw1mentioning

confidence: 95%

“…14,15 These PW1-expressing cells were found in multiple adult tissues including skin, gut, BM, and the central nervous system.…”

mentioning

confidence: 99%

Resident PW1 ⁺ Progenitor Cells Participate in Vascular Remodeling During Pulmonary Arterial Hypertension

Dierick

Héry

Hoareau

et al. 2016

Circulation Research

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“…These two courses of the SCs population relate to their Myf5 transcription factor expression: the dominant population Pax7 interstitial cells). Further details on intrinsic regenerative populations associated to skeletal muscle and SCs origins and dynamics can be found elsewhere [23][24][25][26][27].…”

Section: Skeletal Muscle Structure and Intrinsic Healing Mechanismsmentioning

confidence: 99%

Trends in Mesenchymal Stem Cells' Applications for Skeletal Muscle Repair and Regeneration

Caseiro¹,

Pereira²,

Bártolo³

et al. 2015

Progress in Stem Cell Transplantation

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Skeletal muscle injuries are quite frequent in traumatic scenarios, such as war injuries or road-or work-related accidents. The skeletal muscle has good regenerative ability, but the extent or recurrence of muscle injury might impair complete structural and functional recovery. Severe tissue loss overwhelms skeletal muscle´s intrinsic regenerative capabilities and culminates in the development of noncontractile fibrous tissue scar. Conservative RICE -based and surgical treatments show limited efficacy in terms of improving these severe cases outcomes, pressing the need for new approaches on skeletal muscle's therapy. Since the first suggestions of the potential of mesenchymal stem cells for regenerative medicine and tissue engineering, many applications have been explored for a variety of tissues and diseases, including the skeletal muscle, which is the focus of this literature review.

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“…In subsequent decades, Mauro's hypothesis proved true, and a number of studies demonstrated that SCs are the key mediators of post-natal skeletal muscle growth, homeostasis and repair [2][3][4] . The core functions of SCs are the repair of damaged muscle fibers and the maintenance of an adequate pool of stem cells.…”

Section: Satellite Cellsmentioning

confidence: 99%

New insights into the epigenetic control of satellite cells

Moresi

Marroncelli

Adamo

2015

WJSC

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Epigenetics finely tunes gene expression at a functional level without modifying the DNA sequence, thereby contributing to the complexity of genomic regulation. Satellite cells (SCs) are adult muscle stem cells that are important for skeletal post-natal muscle growth, homeostasis and repair. The understanding of the epigenome of SCs at different stages and of the multiple layers of the post-transcriptional regulation of gene expression is constantly expanding. Dynamic interactions between different epigenetic mechanisms regulate the appropriate timing of muscle-specific gene expression and influence the lineage fate of SCs. In this review, we report and discuss the recent literature about the epigenetic control of SCs during the myogenic process from activation to proliferation and from their commitment to a muscle cell fate to their differentiation and fusion to myotubes. We describe how the coordinated activities of the histone methyltransferase families Polycomb group (PcG), which represses the expression of developmentally regulated genes, and Trithorax group, which antagonizes the repressive activity of the PcG, regulate myogenesis by restricting gene expression in a time-dependent manner during each step of the process. We discuss how histone acetylation and deacetylation occurs in specific loci throughout SC differentiation to enable the time-dependent transcription of specific genes. Moreover, we describe the multiple roles of microRNA, an additional epigenetic mechanism, in regulating gene expression in SCs, by repressing or enhancing gene transcription or translation during each step of myogenesis. The importance of these epigenetic pathways in modulating SC activation and differentiation renders them as promising targets for disease interventions. Understanding the most recent findings regarding the epigenetic mechanisms that regulate SC behavior is useful from the perspective of pharmacological manipulation for improving muscle regeneration and for promoting muscle homeostasis under pathological conditions.

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Defining skeletal muscle resident progenitors and their cell fate potentials

Cited by 129 publications

References 50 publications

Resident PW1 ⁺ Progenitor Cells Participate in Vascular Remodeling During Pulmonary Arterial Hypertension

Resident PW1 ⁺ Progenitor Cells Participate in Vascular Remodeling During Pulmonary Arterial Hypertension

Trends in Mesenchymal Stem Cells' Applications for Skeletal Muscle Repair and Regeneration

New insights into the epigenetic control of satellite cells

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Defining skeletal muscle resident progenitors and their cell fate potentials

Cited by 129 publications

References 50 publications

Resident PW1 + Progenitor Cells Participate in Vascular Remodeling During Pulmonary Arterial Hypertension

Resident PW1 + Progenitor Cells Participate in Vascular Remodeling During Pulmonary Arterial Hypertension

Trends in Mesenchymal Stem Cells' Applications for Skeletal Muscle Repair and Regeneration

New insights into the epigenetic control of satellite cells

Contact Info

Product

Resources

About

Resident PW1 ⁺ Progenitor Cells Participate in Vascular Remodeling During Pulmonary Arterial Hypertension

Resident PW1 ⁺ Progenitor Cells Participate in Vascular Remodeling During Pulmonary Arterial Hypertension