Defining Present Blood Component Transfusion Practices in Trauma Patients: Papers From the Trauma Outcomes Group

Holcomb, John B.; Ce, Wade; Kj, Brasel; Vercruysse, Gary; Macleod, Jana; Rp, Dutton; Jc, Duchesne; Ne, McSwain; Muskat, Peter; Johannigamn, J; Hm, Cryer; Tillou, Areti; Mj, Cohen; Jf, Pittet; Knudson, Paula; Moya, de; Ma, Schreiber; Tieu, Brandon H.; Brundage, Susan I.; Lm, Napolitano; Brunsvold, Melissa E.; Kc, Sihler; Beilman, Greg J.; Ab, Peitzman; Ms, Zenait; Sperry, Jason L.; Alarcon, Louis H.; Ma, Croce; Jp, Minei; Kozar, Rosemary A.; Ea, González; Rm, Stewart; Sm, Cohn; Je, Mickalek; Em, Bulger; Ba, Cotton; Tc, Nunez; Ivatury, Rao R.; Jw, Meredith; Miller, Peter M.; Gj, Pomper; Marin, Benoît

doi:10.1097/ta.0b013e318227ed13

Cited by 18 publications

(6 citation statements)

References 23 publications

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“…Several studies have supported the use of a 1:1:1 platelet to FPP to RBC ratio when transfusing severely injured patients [13, 14, 98, 99]. However, the results of these studies may have been affected by survival bias [100-103].…”

Section: Transfusion Of Blood and Plasmamentioning

confidence: 99%

Coagulopathy After Severe Pediatric Trauma

Christiaans¹,

Duhachek-Stapelman

Russell

et al. 2014

Shock

105

106

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Trauma remains the leading cause of morbidity and mortality in the United States among children from the age 1 year to 21 years old. The most common cause of lethality in pediatric trauma is traumatic brain injury (TBI). Early coagulopathy has been commonly observed after severe trauma and is usually associated with severe hemorrhage and/or traumatic brain injury. In contrast to adult patients, massive bleeding is less common after pediatric trauma. The classical drivers of trauma-induced coagulopathy (TIC) include hypothermia, acidosis, hemodilution and consumption of coagulation factors secondary to local activation of the coagulation system following severe traumatic injury. Furthermore, there is also recent evidence for a distinct mechanism of TIC that involves the activation of the anticoagulant protein C pathway. Whether this new mechanism of posttraumatic coagulopathy plays a role in children is still unknown. The goal of this review is to summarize the current knowledge on the incidence and potential mechanisms of coagulopathy after pediatric trauma and the role of rapid diagnostic tests for early identification of coagulopathy. Finally, we discuss different options for treating coagulopathy after severe pediatric trauma.

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Section: Transfusion Of Blood and Plasmamentioning

confidence: 99%

Coagulopathy After Severe Pediatric Trauma

Christiaans¹,

Duhachek-Stapelman

Russell

et al. 2014

Shock

105

106

View full text Add to dashboard Cite

show abstract

“…10 Publications concerning MT have doubled during the past decade. This has largely been spurred by the appreciation of acute traumatic coagulopathy.…”

Section: Discussionmentioning

confidence: 99%

Toward a better definition of massive transfusion

Sharpe

Weinberg

Magnotti

et al. 2012

Journal of Trauma and Acute Care Surgery

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“…Holcomb and others have published data that show a survival benefit to higher ratios (approaching 1:1) of FFP: PRBC administration during massive transfusion. 14,15,16 However, the validity of this conclusion has been called into question. 17 The aforementioned studies were cross-sectional in nature and did not take into account the temporal change that exists in the FFP: PRBC ratio, leaving them prone to survival bias.…”

Section: Discussionmentioning

confidence: 99%

Revisiting Early Postinjury Mortality: are they Bleeding Because they are Dying or Dying Because they are Bleeding?

Moore

Morton

et al. 2012

Journal of Surgical Research

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Background-Intense debate continues in the search of the optimal ratio of blood components to deliver preemptively in the critically injured patient anticipated to require a massive transfusion. A major challenge is distinguishing patients with refractory coagulopathy versus those with overwhelming injuries who will perish irrespective of blood component administration. The hypothesis of this clinical study is that a predominant number of early deaths from hemorrhage are irretrievable despite an aggressive transfusion policy.

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Defining Present Blood Component Transfusion Practices in Trauma Patients: Papers From the Trauma Outcomes Group

Cited by 18 publications

References 23 publications

Coagulopathy After Severe Pediatric Trauma

Coagulopathy After Severe Pediatric Trauma

Toward a better definition of massive transfusion

Revisiting Early Postinjury Mortality: are they Bleeding Because they are Dying or Dying Because they are Bleeding?

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