Defining nocturnal polyuria in women

Baines, Georgina; Silva, Ana Sofia Da; Cardozo, Linda; Bach, Fiona; Parsons, Matthew; Robinson, Dudley; Toozs‐Hobson, Philip

doi:10.1002/nau.24546

Cited by 4 publications

(6 citation statements)

References 25 publications

(64 reference statements)

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“…In this study, we did find a higher rate of nocturnal polyuria in the nocturia-BD group (Table 4 ), and this finding is in line with the concept of nocturnal polyuria as one of the main causes of nocturia 12 . Thus, this BD classification system seems to be a reasonable tool for classifying the nocturia-BD group in women with storage lower urinary tract symptoms.…”

Section: Discussionsupporting

confidence: 89%

“…For instance, the main medical treatments for OAB include antimuscarinics, beta 3-agonist, or combination therapy. Nonetheless, a total of 8.2% (179/2127) of OAB women were allocated into the nocturia-BD group (Table 1 ), and women in the nocturia-BD group may be better treated by desmopressin 12 , 13 , instead of antimuscarinics or beta-3 agonist. In addition, prolonged treatment was suggested to decrease retreatment in OAB women with small bladder capacity 14 .…”

Section: Discussionmentioning

confidence: 99%

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Feasibility and clinical implications of 3-day bladder diary derived classification of female storage lower urinary tract symptoms

Hsiao

Lin

2022

Sci Rep

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Our aim was to assess the feasibility of a bladder diary (BD) classification as a surrogate for urodynamic studies in women with storage lower urinary tract symptoms. A total of 3823 women who underwent urodynamic studies were reviewed. Nearly the scores of Patient Perception of Bladder Condition, Indevus Urgency Severity Scale and Overactive Bladder Symptom Score decreased gradually from the overactive bladder (OAB) wet-BD, OAB dry-BD, hypersensitive bladder (HSB) -BD, nocturia-BD to normal-BD groups (all p < 0.001). In addition, there is a trend that the rates of bladder oversensitivity decreased gradually from the OAB wet-BD, OAB dry-BD, HSB-BD, nocturia-BD to normal-BD groups (chi-square test, p < 0.001). Moreover, almost the volumes of first desire to void, normal desire to void, strong desire to void, and urgency increased gradually from the OAB wet-BD, OAB dry-BD, HSB-BD, nocturia-BD to normal-BD groups (all p < 0.001). Thus, this BD classification is correlated significantly with symptom severity, the rate of bladder oversensitivity, and bladder capacity. Nonetheless, a combination of urodynamics, clinical history, and BD is still needed for a thorough diagnosis, but that BD provides an efficient diagnosis in a proportion of patients.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Feasibility and clinical implications of 3-day bladder diary derived classification of female storage lower urinary tract symptoms

Hsiao

Lin

2022

Sci Rep

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“…The inclusion of women in EpiNP offers new insight into NP across the lifespan for women. Baines et al [29] compared NP prevalence using NPI and NUP90 definitions for women attending a urogynecology clinic and found that NP prevalence was much higher when using agedependent NPI thresholds (NPI >20% for those 65 yr and >33% for those >65 yr, with rates ranging from 58.4% to 77.5%, respectively). However, for NUP90 as a definition the prevalence was much lower at 17.9%, with no agedependent threshold used.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Nocturnal Polyuria in the United States: Results from the Epidemiology of Nocturnal Polyuria Study

Weiss

Bosch

Chapple

et al. 2022

European Urology Focus

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Background: The prevalence of nocturnal polyuria (NP), which is passing large volumes of urine during the main sleep period, has been investigated primarily in middle-aged to older men. There is thus a gap in the NP evidence base for women and for younger individuals. Objective: To estimate the prevalence of nocturia due to NP in the USA. Design, setting, and participants: This large epidemiologic study used a US populationrepresentative sample of men and women aged !30 yr to assess the prevalence of NP (NCT04125186). Outcome measurements and statistical analysis: Consenting participants completed an online survey (Lower Urinary Tract Symptoms Tool and comorbidities). All who reported two or more voids per night and 100 random respondents each reporting no or one void per night were asked to complete a 3-d bladder diary. Two NP definitions were used: nocturnal urine production >90 ml/h (NUP90) and Nocturnal Polyuria Index >0.33 (NPI33). Crude and population-adjusted prevalence results were calculated from completed diaries for the following subgroups by sex and age: idiopathic NP; NP with overactive bladder (NP-OAB) or bladder outlet obstruction (NP-BOO; men only); NP associated with other comorbidities; and no NP (did not meet the NPI33 or NUP90 definition). Results and limitations: Among the 10,190 respondents who completed the survey, the mean age was 54.4 yr (range 30-95); 3,339 reported two or more nocturnal voids and 1,763 completed the 3-d diary (response rate 49.3%). The adjusted overall NP prevalence was 31.5% among men and 38.5% among women using the NPI33 definition, and 23.8% among men and 18.1% among women using NUP90. The adjusted idiopathic NP prevalence was lower among men (NPI33: 5.2%; NUP90: 1.4%) than among women (NPI33: 9.8%; NUP90: 4.0%). The prevalence of idiopathic NP decreased with age as NP associated with other possible causes increased with age in men (most common, BOO) and women (most common, OAB).

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“…A recent study conducted in 1,400 women found that prevalence of NP differed considerably, from 21.5%e77%, depending upon NP definition. 16 As such, a large cross-sectional, populationrepresentative study of both men and women (Epidemiology of Nocturnal Polyuria [EpiNP] Study) was conducted to assess the prevalence of NP in the U.S.; adjusted overall NP prevalence using NPI33 was 31.5% (men) and 38.5% (women), and was 23.8% (men) and 18.1% (women) using NUP90. 17 The main objective of this analysis was to compare bladder diary data parameters by NP definition (NPI33 and NUP90) to further evaluate the characteristics of NP definitions and examine potential sex-based differences.…”

mentioning

confidence: 99%

“…A recent study conducted in 1,400 women found that prevalence of NP differed considerably, from 21.5%–77%, depending upon NP definition. 16…”

mentioning

confidence: 99%

Differences in the Prevalence of Nocturnal Polyuria in the U.S. by Definition: Results from the Epidemiology of Nocturnal Polyuria Study

Bosch

Chapple

Rosenberg³

et al. 2022

Journal of Urology

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Purpose:Prevalence data on nocturnal polyuria (NP), nocturia caused by overproduction of urine during sleep, is primarily limited to men and varies by NP definition. This U.S.-representative epidemiological study of men and women ≥30 years old assessed the prevalence of NP.Materials and Methods:Consenting participants completed the baseline EpiNP (Epidemiology of Nocturnal Polyuria) survey (eg Lower Urinary Tract Symptoms Tool, comorbidities). All reporting ≥2 voids/night and a target of 100 random respondents reporting 0 or 1 void/night were asked to complete 3-day bladder diaries. NP was defined as nocturnal polyuria index (NPI) >0.33 (NPI33) and nocturnal urine production >90 ml/hour (NUP90). Extrapolated prevalence was stratified by sex and subgroups: idiopathic (without underlying causes), associated with overactive bladder (NPOAB), bladder outlet obstruction (NPBOO; men) and comorbidities. Voided volumes and timing, including first uninterrupted sleep period, were assessed by subgroup.Results:A total of 10,190 individuals completed the baseline survey; mean age (range) was 54.4 (30–95). A total of 3,938 individuals were invited to complete the diary; 1,763 (49.3%) completed 3-day bladder diaries. Urine production (maximum nighttime volume, total volume, nocturnal urine production, nocturia index) was higher in both men and women with idiopathic NP and comorbidities. The median number of nighttime voids was greatest for NPBOO in men and NPOAB in women. Bother associated with nighttime voiding differed by NP subgroup but was highest in NPBOO for men (NPI33: 69.6%; NUP90: 71.1%) and NPOAB for women (NPI33: 67.5%; NUP90: 66.0%).Conclusions:This population-based NP prevalence study including men and women characterizes NP subgroups and provides insights into nocturia treatment by emphasizing factors influencing urine production versus factors influencing bladder capacity.

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Defining nocturnal polyuria in women

Cited by 4 publications

References 25 publications

Feasibility and clinical implications of 3-day bladder diary derived classification of female storage lower urinary tract symptoms

Feasibility and clinical implications of 3-day bladder diary derived classification of female storage lower urinary tract symptoms

The Prevalence of Nocturnal Polyuria in the United States: Results from the Epidemiology of Nocturnal Polyuria Study

Differences in the Prevalence of Nocturnal Polyuria in the U.S. by Definition: Results from the Epidemiology of Nocturnal Polyuria Study

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