Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort

Gullo, Terese R.; Golightly, Yvonne M.; Cleveland, Rebecca J.; Renner, Jordan B.; Callahan, Leigh F.; Jordan, Joanne M.; Kraus, Virginia B.; Nelson, Amanda

doi:10.1016/j.semarthrit.2018.10.001

Cited by 34 publications

(23 citation statements)

References 58 publications

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“…Consistent with other studies, women were more likely to have pain at multiple joint sites than men [ 8 ]. The number of painful joint sites was associated with having two or more comorbidities, independently of age.…”

Section: Discussionsupporting

confidence: 90%

“…As MJOA has been variously defined in the literature as being ≥2 or ≥3 joint sites [ 8 ], we carried out sensitivity analyses using ordinal logistic regression with categories of joint count site grouping the number of painful joint sites as 1, 2–3 and 4+, and 1–2, 3–4 and 5+. We further replicated our analyses excluding cases with only one joint site to eliminate the possibility that our findings had been affected by trauma-related single-joint OA [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

“…Multiple joint OA (MJOA) is often referred to as generalized OA (GOA), a term first proposed by Kellgren and Moore [ 7 ]. A recent systematic review of literature published from 1952 to 2017 found only 30 eligible studies that included a clear definition of MJOA and found little consensus between study definitions [ 8 ]. Hand joints were included in the definition of MJOA in all but two of the 27 studies that included specific joints in their definition, and all but four specified the knee.…”

Section: Introductionmentioning

confidence: 99%

“…While generally neglected, the impact of having MJOA is considerable. No matter how it is defined or what outcomes are considered, clinical and community studies that have investigated the impact of having multiple joint vs single joint OA consistently show a more negative impact for MJOA with greater disability and reduced quality of life [ 8 , 10 , 14–17 ].…”

Section: Introductionmentioning

confidence: 99%

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The contribution of age and obesity to the number of painful joint sites in individuals reporting osteoarthritis: a population-based study

et al. 2020

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Objective To investigate the association of OA risk factors with number of painful joint sites in a representative population sample. Methods Analysis of the 2009 Survey on Living with Chronic Diseases in Canada – Arthritis Component (n = 1614) for respondents reporting symptomatic OA. Variables: painful joints sites (hands, wrists, elbows, shoulders, hips, knees, ankles, feet, back, neck), joint symptom duration, sociodemographic characteristics, smoking, comorbidities and BMI. Zero-truncated negative binomial regressions were used to investigate the association between number of painful joint sites and the variables. Generalizability of findings was assessed by a similar analysis in a clinical hip/knee OA sample. Results The sample comprised 73% women and 56% were aged <65 years. The mean number of painful joint sites was 3.8: 84% reported pain at ≥2 sites, and 45% at ≥4 sites. Age, BMI, education and smoking were not associated with the number of joint sites. Significant associations were found with being female [rate ratio (RR) = 1.23, 95% CI 1.09, 1.39], having more comorbidities (RR = 1.11, 95% CI 1.07, 1.15) and longer symptom duration (RR = 1.16, 95% CI 1.09, 1.24), although the increase in joint sites with duration was small. Similar regression results were found with the clinical OA sample. Conclusion The lack of an association of age and BMI (obesity) with number of painful joint sites in OA raises questions about the role of these risk factors and our understanding of OA as a multi-joint disease. Filling this knowledge gap is critical to making progress with defining OA phenotypes and identifying potential aetiological mechanisms.

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Section: Discussionsupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The contribution of age and obesity to the number of painful joint sites in individuals reporting osteoarthritis: a population-based study

et al. 2020

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“…The presentation of osteoarthritis (OA) varies immensely e affecting adults of all ages and involving different joints throughout the body 1 . Although hand osteoarthritis (HOA) is exceedingly common and will affect 4 in 10 people by age 85 2 , this joint site is understudied in comparison to other sites, like the knee.…”

mentioning

confidence: 99%

Incidence and progression of hand osteoarthritis in a large community-based cohort: the Johnston County Osteoarthritis Project

Snyder

Álvarez

Golightly

et al. 2020

Osteoarthritis and Cartilage

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Objective: To describe the incidence and progression of radiographic and symptomatic hand osteoarthritis (rHOA and sxHOA) in a large community-based cohort. Design: Data were from the Johnston County OA Project (1999e2015, 12 ± 1.2 years follow-up, age 45þ). Participants had bilateral hand radiographs each visit, read for KellgreneLawrence grade (KLG) at 30 joints. We defined rHOA as KLG !2 in !1 joint. SxHOA was defined in a hand/joint with rHOA and selfreported symptoms or tenderness on exam. Incidence was assessed in those without, while progression was assessed in those with, baseline rHOA. Proportions or medians are reported; differences by sex and race were assessed using models appropriate for dichotomous or continuous definitions, additionally adjusted for age, education, body mass index (BMI), and weight change. Results: Of 800 participants (68% women, 32% African American, mean age 60 years), 327 had baseline rHOA and were older, more often white and female, than those without rHOA (n ¼ 473). The incidence of HOA was high, for rHOA (60%) and for sxHOA (13%). Women were more likely than men to have incident HOA, particularly for distal interphalangeal joint radiographic osteoarthritis (DIP rOA) (adjusted odds ratios (aOR) 1.60 95% confidence intervals (95% CI) [1.03, 2.49]) and sxHOA (aOR 2.98 [1.50, 5.91]). Progressive HOA was more similar by sex, although thumb base rOA progressed more frequently in women than in men (aOR 2.56 [1.44, 4.55]). Particularly HOA incidence, but also progression, was more frequent among whites compared with African Americans. Conclusion:This study provides much needed information about the natural history of HOA, a common and frequently debilitating condition, in the general population.

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Platelet-Rich Plasma Injections vs Placebo for Patients With Ankle Osteoarthritis

Barber

Manning

Desai

2022

JAMA

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HCV testing, and 10.7% (n = 188) offered HCV treatment. Among non-OTPs in 2020, 46.6% (n = 3024) offered HIV testing, 17.9% (n = 1163) offered HIV treatment, 45.8% (n = 2976) offered HCV testing, and 20.5% (n = 1334) offered HCV treatment.For both OTPs and non-OTPs, HIV and HCV testing and treatment were most often available in federally owned facilities and facilities with inpatient services, with the proportion of outpatient-only facilities providing such services being low (Table 2).Of the 117 OTPs in the 7 Ending the HIV Epidemic highpriority rural states in 2020, 46.2% (n = 54) and 4.3% (n = 5) offered HIV testing and treatment, respectively.Discussion | Despite an increasing number of substance use disorder treatment facilities that offered medication for opioid use disorder, the proportion of facilities that also offered HIV and HCV testing did not change between 2017 and 2020. In 2020, only half of the facilities offered HIV and HCV testing. The stagnant trends, including among OTPs, are troubling, as a prior study found declines in HIV testing availability among OTPs between 2000 and 2011. 5 Regardless of OTP status, HIV and HCV testing and treatment availability was particularly low in outpatient-only facilities that can potentially establish routine care and in highpriority rural states with increasing HIV/HCV risk. 3,6 Limitations of the study include that the findings may not be generalizable to clinicians who prescribe medication to treat opioid use disorder outside of the specialty treatment system. While integration of medication for opioid use disorder into primary care and infectious disease clinics remains important, these data highlight that increased efforts are needed to better integrate HIV and HCV testing and treatment in the specialty treatment system.

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Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort

Cited by 34 publications

References 58 publications

The contribution of age and obesity to the number of painful joint sites in individuals reporting osteoarthritis: a population-based study

The contribution of age and obesity to the number of painful joint sites in individuals reporting osteoarthritis: a population-based study

Incidence and progression of hand osteoarthritis in a large community-based cohort: the Johnston County Osteoarthritis Project

Platelet-Rich Plasma Injections vs Placebo for Patients With Ankle Osteoarthritis

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