Defining Human Regulatory T Cells beyond FOXP3: The Need to Combine Phenotype with Function
Chelsea Gootjes,
Jaap Jan Zwaginga,
Bart O. Roep
et al.
Abstract:Regulatory T cells (Tregs) are essential to maintain immune homeostasis by promoting self-tolerance. Reduced Treg numbers or functionality can lead to a loss of tolerance, increasing the risk of developing autoimmune diseases. An overwhelming variety of human Tregs has been described, based on either specific phenotype, tissue compartment, or pathological condition, yet the bulk of the literature only addresses CD25-positive and CD127-negative cells, coined by naturally occurring Tregs (nTregs), most of which … Show more
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