Defining Hepatocellular Chimerism in a Liver Failure Patient Bridged With Hepatocyte Infusion

Fisher, R A; Bu, Dawen; Thompson, M; Tisnado, J; Prasad, U; Sterling, Richard K.; Posner, M; Strom, Steven

doi:10.1097/00007890-199905150-00053

Cited by 22 publications

(35 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…29,30,35,36 In one study, only 3 of 7 patients recovered from transplantation of fetal hepatocytes 29 and, in another, survival was prolonged between 12 and 52 days in 3 of 5 patients who underwent transplantation with hepatocytes. 30 In these studies, 10 9 to 10 10 total cells were used.…”

Section: Discussionmentioning

confidence: 98%

Stem Cell Therapy for Liver Disease: Parameters Governing the Success of Using Bone Marrow Mesenchymal Stem Cells

Kuo¹,

et al. 2008

View full text Add to dashboard Cite

Background & Aims-Liver transplantation is the primary treatment for various end-stage hepatic diseases but is hindered by the lack of donor organs and by complications associated with rejection and immunosuppression. There is increasing evidence to suggest the bone marrow is a transplantable source of hepatic progenitors. We previously reported that multipotent bone marrow-derived mesenchymal stem cells differentiate into functional hepatocyte-like cells with almost 100% induction frequency under defined conditions, suggesting the potential for clinical applications. The aim of this study was to critically analyze the various parameters governing the success of bone marrow-derived mesenchymal stem cell-based therapy for treatment of liver diseases.

show abstract

Section: Discussionmentioning

confidence: 98%

Stem Cell Therapy for Liver Disease: Parameters Governing the Success of Using Bone Marrow Mesenchymal Stem Cells

Kuo¹,

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Nevertheless, cell-based therapies are emerging as an alternative to whole-organ transplantation. Hepatocyte transplantation has been used to bridge patients to whole-organ transplantation [7,69], to decrease mortality in acute liver failure [18,58], and for treatment of metabolic liver disease [3,16,19,22,29,30,47,48,66,67,69]. Cell transplantation is less invasive than whole-organ transplantation and can be performed repeatedly.…”

Section: Introductionmentioning

confidence: 99%

Present status and perspectives of cell-based therapies for liver diseases

Nüssler

König

Ott

et al. 2006

Journal of Hepatology

176

129

View full text Add to dashboard Cite

“…restoration of urea synthesis) followed by the relapse of disease symptoms due to transplant rejection [Allen and Soriano, 2001;Horslen and Fox, 2004] or due to another reason [Mitry et al, 2004], which finally progressed to liver failure and the need for organ transplantation [Strom et al, 1999]. For therapy of nongenetic liver disorders (cirrhosis, acute liver inflammation), conflicting results were also obtained, with either favorable [Bilir et al, 1996;Soliano et al, 1997;Fisher et al, 2000] or fatal outcomes [Bilir et al, 1996[Bilir et al, , 2000.…”

Section: Nonstem Cells (Primary Hepatocytes)mentioning

confidence: 99%

Liver Regenerative Medicine: Advances and Challenges

Chistiakov

2012

Cells Tissues Organs

View full text Add to dashboard Cite

Liver transplantation is the standard care for many end-stage liver diseases. However, donor organs are scarce and some people succumb to liver failure before a donor is found. Liver regenerative medicine is a special interdisciplinary field of medicine focused on the development of new therapies incorporating stem cells, gene therapy and engineered tissues in order to repair or replace the damaged organ. In this review we consider the emerging progress achieved in the hepatic regenerative medicine within the last decade. The review starts with the characterization of liver organogenesis, fetal and adult stem/progenitor cells. Then, applications of primary hepatocytes, embryonic and adult (mesenchymal, hematopoietic and induced pluripotent) stem cells in cell therapy of liver diseases are considered. Current advances and challenges in producing mature hepatocytes from stem/progenitor cells are discussed. A section about hepatic tissue engineering includes consideration of synthetic and natural biomaterials in engineering scaffolds, strategies and achievements in the development of 3D bioactive matrices and 3D hepatocyte cultures, liver microengineering, generating bioartificial liver and prospects for fabrication of the bioengineered liver.

show abstract

Defining Hepatocellular Chimerism in a Liver Failure Patient Bridged With Hepatocyte Infusion

Cited by 22 publications

References 0 publications

Stem Cell Therapy for Liver Disease: Parameters Governing the Success of Using Bone Marrow Mesenchymal Stem Cells

Stem Cell Therapy for Liver Disease: Parameters Governing the Success of Using Bone Marrow Mesenchymal Stem Cells

Present status and perspectives of cell-based therapies for liver diseases

Liver Regenerative Medicine: Advances and Challenges

Contact Info

Product

Resources

About