Defining Diagnostic Criteria for Prostatic Ductal Adenocarcinoma at                     Multiparametric MRI

Ranasinghe, Weranja; Troncoso, Patricia; Surasi, Devaki Shilpa; Rovira, Juan Ibarra; Bhosale, Priya; Szklaruk, Janio; Kokorovic, Andrea; Wang, Xuemei; Elsheshtawi, Mohamed A; Zhang, Miao; Aparicio, Ana; Chapin, Brian F.; Bathala, Tharakeswara K.

doi:10.1148/radiol.204732

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…However, most lesions in our study were ISUP GG 5, and there were few remaining normal tissues accompanied by significant hyperplasia and/or inflammation, or even scattered tumor foci, which were unsuitable for correction. Finally, the gluteus maximus, which showed a relatively stable signal and was used for T2-weighted signal and ADC value correction, was used to calibrate the influence of different scanning protocols and was expected to be comparable across different patients [ 30 31 ]. Our results showed that the ADC ratio in IDC-P was lower than that in PAC and was helpful in predicting IDC-P in the nomogram.…”

Section: Discussionmentioning

confidence: 99%

Nomogram Models for Distinguishing Intraductal Carcinoma of the Prostate From Prostatic Acinar Adenocarcinoma Based on Multiparametric Magnetic Resonance Imaging

Yang

Zhang

et al. 2023

Korean J Radiol

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Objective To compare multiparametric magnetic resonance imaging (MRI) features of intraductal carcinoma of the prostate (IDC-P) with those of prostatic acinar adenocarcinoma (PAC) and develop prediction models to distinguish IDC-P from PAC and IDC-P with a high proportion (IDC ≥ 10%, hpIDC-P) from IDC-P with a low proportion (IDC < 10%, lpIDC-P) and PAC. Materials and Methods One hundred and six patients with hpIDC-P, 105 with lpIDC-P and 168 with PAC, who underwent pretreatment multiparametric MRI between January 2015 and December 2020 were included in this study. Imaging parameters, including invasiveness and metastasis, were evaluated and compared between the PAC and IDC-P groups as well as between the hpIDC-P and lpIDC-P subgroups. Nomograms for distinguishing IDC-P from PAC, and hpIDC-P from lpIDC-P and PAC, were made using multivariable logistic regression analysis. The discrimination performance of the models was assessed using the receiver operating characteristic area under the curve (ROC-AUC) in the sample, where the models were derived from without an independent validation sample. Results The tumor diameter was larger and invasive and metastatic features were more common in the IDC-P than in the PAC group ( P < 0.001). The distribution of extraprostatic extension (EPE) and pelvic lymphadenopathy was even greater, and the apparent diffusion coefficient (ADC) ratio was lower in the hpIDC-P than in the lpIDC-P group ( P < 0.05). The ROC-AUCs of the stepwise models based solely on imaging features for distinguishing IDC-P from PAC and hpIDC-P from lpIDC-P and PAC were 0.797 (95% confidence interval, 0.750–0.843) and 0.777 (0.727–0.827), respectively. Conclusion IDC-P was more likely to be larger, more invasive, and more metastatic, with obviously restricted diffusion. EPE, pelvic lymphadenopathy, and a lower ADC ratio were more likely to occur in hpIDC-P, and were also the most useful variables in both nomograms for predicting IDC-P and hpIDC-P.

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Section: Discussionmentioning

confidence: 99%

Nomogram Models for Distinguishing Intraductal Carcinoma of the Prostate From Prostatic Acinar Adenocarcinoma Based on Multiparametric Magnetic Resonance Imaging

Yang

Zhang

et al. 2023

Korean J Radiol

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“…The bone metastases are more likely to be osteolytic 6. On MRI, the presence of well-defined margin, lobulation, and/or hypointense rim are suggestive of prostatic ductal adenocarcinoma 7,8. FDG PET/CT findings of prostatic ductal adenocarcinoma are rarely reported.…”

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confidence: 99%

“…6 On MRI, the presence of well-defined margin, lobulation, and/or hypointense rim are suggestive of prostatic ductal adenocarcinoma. 7,8 FDG PET/CT findings of prostatic ductal adenocarcinoma are rarely reported. A few case reports demonstrate that prostatic ductal adenocarcinoma may show low PSMA expression and high glycolytic activity.…”

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confidence: 99%

FDG PET/CT in a Case of Pure Ductal Adenocarcinoma of the Prostate With Osteolytic Metastases and Normal PSA Level

et al. 2023

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Prostatic ductal adenocarcinoma is an uncommon aggressive subtype of prostate carcinoma. It is more likely to present with advanced stage and lower prostate-specific antigen. We describe FDG PET/CT findings in a case of pure prostatic ductal adenocarcinoma with lymph node, bone and lung metastases, normal serum prostate-specific antigen level, and elevated serum carbohydrate antigen 19-9 and carbohydrate antigen 724 levels. The primary tumor, and lymph node and bone metastases were hypermetabolic. All the bone metastases were osteolytic. The multiple lung metastases showed no significant FDG uptake, which may be due to small size.

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“…It is more likely to be poorly differentiated and to present with advanced stage 4–6 . It may be challenging to distinguish prostatic ductal adenocarcinoma from ordinary acinar adenocarcinoma on MRI 7,8 . There are currently limited data regarding FDG and PSMA PET imaging in prostatic ductal adenocarcinoma.…”

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confidence: 99%

“…[4][5][6] It may be challenging to distinguish prostatic ductal adenocarcinoma from ordinary acinar adenocarcinoma on MRI. 7,8 There are currently limited data regarding FDG and PSMA PET imaging in prostatic ductal adenocarcinoma. This case adds to a few other cases of prostatic ductal adenocarcinoma showing low PSMA expression and high glycolytic activity.…”

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confidence: 99%

68Ga-PSMA-11 and 18F-FDG PET/CT in a Case of Ductal Adenocarcinoma of the Prostate

et al. 2022

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Prostatic ductal adenocarcinoma is an uncommon variant of prostatic carcinoma with aggressive behavior and worse prognosis. We describe 68Ga-PSMA-11 and FDG PET/CT findings in a case of prostatic ductal adenocarcinoma with pelvic lymph node metastases. The majority of the prostate tumor and all the metastatic lesions showed no significant PSMA uptake but intense FDG uptake. The role of PSMA and FDG PET in the management of prostatic ductal adenocarcinoma needs to be investigated in a large number of patients.

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Defining Diagnostic Criteria for Prostatic Ductal Adenocarcinoma at Multiparametric MRI

Cited by 7 publications

References 28 publications

Nomogram Models for Distinguishing Intraductal Carcinoma of the Prostate From Prostatic Acinar Adenocarcinoma Based on Multiparametric Magnetic Resonance Imaging

Nomogram Models for Distinguishing Intraductal Carcinoma of the Prostate From Prostatic Acinar Adenocarcinoma Based on Multiparametric Magnetic Resonance Imaging

FDG PET/CT in a Case of Pure Ductal Adenocarcinoma of the Prostate With Osteolytic Metastases and Normal PSA Level

68Ga-PSMA-11 and 18F-FDG PET/CT in a Case of Ductal Adenocarcinoma of the Prostate

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