Defining Design Targets for Tissue Engineering Scaffolds

Hollister, Scott J.; Liao, Elly E.; Moffitt, Erin N.; Jeong, Claire G.; Kemppainen, Jessica M.

doi:10.1007/978-3-540-77755-7_38

Cited by 16 publications

(17 citation statements)

References 76 publications

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“…In terms of porosity, Hollister et al (2009) have reported no statistically significant difference in bone volume within polypropylene fumarate/tri-calcium phosphate (PPF/TCP) scaffolds 30%, 50% and 70% porous, which disagrees with the general idea of higher values of porosity promoting more bone tissue (Bonfield, 2006;Karageorgiou and Kaplan, 2005). These ambiguities result from the complexity and interdependency of many of the microstructure properties and also their effect on the tissue regeneration process (Murphy et al, 2010;Bohner et al, 2011).…”

Section: Introductionmentioning

confidence: 88%

Permeability analysis of scaffolds for bone tissue engineering

Dias

Fernandes

Guedes

et al. 2012

Journal of Biomechanics

181

101

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Section: Introductionmentioning

confidence: 88%

Permeability analysis of scaffolds for bone tissue engineering

Dias

Fernandes

Guedes

et al. 2012

Journal of Biomechanics

181

101

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“…Although relatively simple, this model can characterize 1D mechanical behavior ranging from linear to nonlinear elasticity. Recently, Hollister et al [8] fit a number of tissue stress-strain datasets to this model to provide a common basis for scaffold mechanical design requirements (Table 1). Fitting experimental data to the same constitutive model (Eq.…”

Section: Scaffold Functional Design Requirementsmentioning

confidence: 99%

“…We also tested the permeability of these designed scaffolds, finding ranges of 1.4e À7 to 12.8e À7 m 4 N À1 s À1 for porosities ranging from 53 to 73%. [8] Liu et al [74] developed an inverse SFF technique to create collagen I scaffolds. All scaffolds were dehydrated under vacuum pressure, with some scaffolds subsequently crosslinked using lysine.…”

Section: Designed Controlled Scaffold Manufacturing: Solid Free-form mentioning

confidence: 99%

“…The inverse SFF was also combined with traditional porogen leaching and emulsion techniques to create hierarchical pore structures. We have further extended the inverse SFF techniques [8] to fabricate PCL and POC scaffolds, measuring effective nonlinear elastic, viscoelastic, and permeability properties. We found that 30, 50, and 70% porous POC exhibited nonlinear elastic properties.…”

Section: Designed Controlled Scaffold Manufacturing: Solid Free-form mentioning

confidence: 99%

“…Scaffold mass transport can be characterized by scaffold diffusivity and permeability. As with [8] catalogued native-tissue effective permeability and diffusivity ( Table 2). The effective permeability and diffusivity parameters align with what is commonly known about metabolic activity of tissues.…”

Section: Scaffold-design Requirements For Enhancing Tissue Regenerationmentioning

confidence: 99%

See 2 more Smart Citations

Scaffold Design and Manufacturing: From Concept to Clinic

Hollister¹

2009

Advanced Materials

Self Cite

353

243

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Since Robert Langer and colleagues pioneered the concept of reconstructing tissue using cells transplanted on synthetic polymer matrices in the early 1990s, research in the field of tissue engineering and regenerative medicine has exploded. This is especially true in the development of new materials and structures that serve as scaffolds for tissue reconstruction. The basic tenet of the last two decades holds scaffolds as degradable materials providing temporary function while enhancing tissue regeneration through the delivery of biologics. Although a number of new scaffolding materials and structures have been developed in research laboratories, the application of such materials practice even has been extremely limited. This paper argues that better integration of all these factors is needed to bring scaffolds from "concept to clinic". It reviews current work in all these areas and suggests where future work and funding is needed.

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Mechanical, permeability, and degradation properties of 3D designed poly(1,8 octanediol‐co‐citrate) scaffolds for soft tissue engineering

Jeong

Hollister

2010

J Biomed Mater Res

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Poly(1,8-octanediol-co-citric acid) (POC) is a synthetic biodegradable elastomer that can be processed into 3D scaffolds for tissue engineering. We investigated the effect of designed porosity on the mechanical properties, permeability and degradation profiles of the POC scaffolds. For mechanical properties, scaffold compressive data was fit to a 1D nonlinear elastic model and solid tensile data was fit to a Neohookean incompressible nonlinear elastic model. Chondrocytes were seeded on scaffolds to assess the biocompatibility of POC. Increased porosity was associated with increased degradation rate, increased permeability, and decreased mechanical stiffness which also became less nonlinear. Scaffold characterization in this paper will provide design guidance for POC scaffolds to meet the mechanical and biological parameters needed for engineering soft tissues such as cartilage.

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Defining Design Targets for Tissue Engineering Scaffolds

Cited by 16 publications

References 76 publications

Permeability analysis of scaffolds for bone tissue engineering

Permeability analysis of scaffolds for bone tissue engineering

Scaffold Design and Manufacturing: From Concept to Clinic

Mechanical, permeability, and degradation properties of 3D designed poly(1,8 octanediol‐co‐citrate) scaffolds for soft tissue engineering

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