Defining Constant Versus Variable Phenotypic Features of Women With Polycystic Ovary Syndrome Using Different Ethnic Groups and Populations

Welt, Corrine K.; Arason, G J; Gudmundsson, Johannes; Adams, Judith; Pálsdóttir, Helga Björk; Gudlaugsdottir, Gudbjorg Jona; Ingadottir, G.; Crowley, William F.

doi:10.1097/01.ogx.0000256777.86022.75

Cited by 34 publications

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“…In the study by Wijeyaratne, there was a trend to increased ovarian volume in Asian PCOS patients, but this did not reach statistical significance (19). Welt et al reported similar prevalence of PCO between Caucasian PCOS patients from Boston and Iceland but Icelandic patients had smaller ovaries with decreased follicle number supporting that ovarian morphology may vary in different study populations (25).…”

Section: Discussionmentioning

confidence: 98%

Ethnic differences in Rotterdam criteria and metabolic risk factors in a multiethnic group of women with PCOS studied in Denmark

Glintborg

Mumm

Hougaard

et al. 2010

Clinical Endocrinology

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To cite this version:Dorte Glintborg, Hanne Mumm, David Hougaard, Pernille Ravn, Marianne Andersen. Ethnic differences in Rotterdam criteria and metabolic risk factors in a multiethnic group of women with PCOS studied in Denmark. Clinical Endocrinology, Wiley, 2010, 73 (6) Design: Retrospective trans-sectional study.Patients: 1002 premenopausal women with the diagnoses hirsutism or PCOS were divided according to ethnicity: Caucasian (CA, n=784), Middle East (ME, n=190), Asian (n=14), other (n=14).Measurements: Clinical evaluation (hirsutism, BMI, waist, blood pressure), hormone analyses (testosterone, sex hormone binding globulin, prolactin, lipids, insulin, glucose), and transvaginal ultrasound. Oral glucose tolerance tests (OGTT) (n = 499) and ACTH tests (n = 434) were performed in a subgroup of patients.Results (CA vs. ME women): CA women were older [32(25-37) vs. 25(18-32) years, median (quartiles)]and had increased BMI compared to ME women. After correcting for age and BMI CA women were less hirsute, but had increased testosterone levels compared to ME women. The Rotterdam criteria were fulfilled in 56% of both populations but PCO was diagnosed in 47% CA vs. 29% ME women, p<0.01. CA women had increased blood pressure and smoked at a higher frequency (40 vs. 23%), whereas area under the curve for insulin during OGTT was decreased, all p<0.001. Prolactin levels were significantly lower in CA women compared to ME women [7(5-10) vs. 9(6-12) µg/l] and were inversely associated with smoking status. Conclusion:CA women had a more adverse cardiovascular profile than ME women, whereas insulin sensitivity was higher. The prevalence of the individual Rotterdam criteria differed significantly in the two study populations.

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Section: Discussionmentioning

confidence: 98%

Ethnic differences in Rotterdam criteria and metabolic risk factors in a multiethnic group of women with PCOS studied in Denmark

Glintborg

Mumm

Hougaard

et al. 2010

Clinical Endocrinology

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“…Furthermore, IR has been linked to oxidative stress, subclinical inflammation, and endothelial dysfunction, usually encountered in patients with PCOS. IR constitutes a prerequisite for diabetes mellitus (DM) and/or metabolic syndrome development, and consequently the increased incidence of these two morbidities in women with PCOS, compared with their BMI-matched peers, is expected (5,6,7,8,9). However, the available prospective studies reporting the significantly higher incidence of DM in women with PCOS compared with general population are few and DM is found mainly in obese women with the syndrome (10,11,12).…”

Section: Introductionmentioning

confidence: 99%

Diverse impacts of aging on insulin resistance in lean and obese women with polycystic ovary syndrome: evidence from 1345 women with the syndrome

Livadas

Panidis

Diamanti-Kandarakis

2014

European Journal of Endocrinology

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Background: Polycystic ovary syndrome (PCOS) represents a moving spectrum of hormonal to metabolic abnormalities, as women with the syndrome are aging. Hormonal abnormalities, anovulation, and hyperandrogenic signs were predominant during the early years of PCOS and fade away with the years. Metabolic abnormalities and insulin resistance (IR) remain throughout the PCOS life cycle; however, it is unclear as to how they change, as women with the syndrome are aging. Objective: To evaluate the changes in IR and its associations with clinical, biochemical, hormonal, and ultrasound findings in a large cohort of women with PCOS and controls, as they are aging. Design: A cross-sectional study was carried out to evaluate the diverse impacts of aging on IR. Setting: An outpatient clinic was chosen for the study. Participants: A total of 1345 women with PCOS (Rotterdam criteria) and 302 controls of Caucasian origin and Greek ethnicity comprised the study group. Main outcome and measures: The impact of age on IR, as calculated using homeostasis model assessment of IR (HOMA-IR) index, and several PCOS characteristics were evaluated. Results: In PCOS, age (K0.045G0.008) was negatively, and BMI positively (0.18G0.007) associated with HOMA-IR (R 2 Z0.36).

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“…A high prevalence of PCOM in healthy adolescents, with regular menstrual cycles and with no evidence of clinical hyperandrogenism, has been reported in the 30%-35% range (40)(41)(42), which is similar to the prevalence of 38% and 37% observed in adolescents with hyperandrogenism and or PCOS, respectively, but is lower compared to the prevalence of PCOM 90%-100% in adult women with PCOS (17). Thus, these findings suggest that PCOM during adolescence is not increased in hyperandrogenic adolescents compared to healthy girls, and is less prevalent in the former group compared to adult women with PCOS.…”

Section: Polycystic Ovarian Morphologymentioning

confidence: 53%

“…Hirsutism is defined by a Ferriman score equal or greater than 8, which corresponds to the 95th percentile for European populations. Other studies in less hirsute populations have used a cutoff of 6 and in some cases even of 3 (17)(18)(19). The cutoff for defining hirsutism during adolescence may be lower, due to the short exposure to androgens.…”

Section: Hiperandrogenism (Ha)mentioning

confidence: 99%

A rational approach to the diagnosis of polycystic ovarian syndrome during adolescence

Merino

Codner

Cassorla

2011

Arq Bras Endocrinol Metab

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SUMMARYPolycystic ovarian syndrome (PCOS) is a lifelong disorder characterized by hyperandrogenism and ovulatory dysfunction, with a wide spectrum of clinical symptoms and signs. Three different sets of diagnostic criteria have been established in order to define this disease in adult women, but there is controversy regarding the use of these criteria in adolescence. During puberty, the adult criteria for ovulatory dysfunction does not seem applicable, because an irregular menstrual pattern and a decreased ovulatory rate is a physiologic event during this period of life. Also, a higher prevalence of polycystic ovarian morphology (PCOM) may be observed during this period, so PCOM is not a useful criterion to define PCOS in young women. These findings suggest that a key factor to diagnose to PCOS during adolescence is hyperandrogenism. In addition, since PCOM is not clearly associated with hyperandrogenism during this period of life, the term "polycystic ovarian syndrome" during adolescence creates confusion and may be misleading. Arq Bras Endocrinol Metab. 2011;55(8):590-8 Keywords Hyperandrogenism; hirsutism; polycystic ovarian syndrome; adolescence; diagnosis; puberty; polycystic ovarian morphology; menstrual irregularities; anti-Müllerian hormone SUMáRio A síndrome dos ovários policísticos (SOP) é uma desordem que afeta pacientes por toda a vida e é caracterizada por hiperandrogenismo e disfunção ovariana, com um amplo leque de sintomas e sinais clínicos. Três diferentes conjuntos de critérios diagnósticos foram estabelecidos para definir essa doença em mulheres adultas, mas existem controvérsias relacionadas ao uso desses critérios na adolescência. Durante a puberdade, o critério de disfunção ovariana usado em adultos não parece aplicável, porque um padrão menstrual irregular e uma menor taxa de ovulação são eventos fisiológicos nesse período da vida. Além disso, uma maior prevalência de morfologia ovariana policística (MOP) pode ser observada nesse período, de forma que a MOP não é um critério útil para se definir a SOP em mulheres jovens. Esses achados sugerem que o hiperandrogenismo é um fator-chave para o diagnóstico da SOP na adolescência. Além disso, como a MOP não está claramente associada com o hiperandrogenismo durante esse período da vida, o termo "síndrome dos ovários policísticos" durante a adolescência cria confusão e pode ser errôneo. Arq Bras Endocrinol Metab. 2011;55(8):590-8 Descritores

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Defining Constant Versus Variable Phenotypic Features of Women With Polycystic Ovary Syndrome Using Different Ethnic Groups and Populations

Cited by 34 publications

References 0 publications

Ethnic differences in Rotterdam criteria and metabolic risk factors in a multiethnic group of women with PCOS studied in Denmark

Ethnic differences in Rotterdam criteria and metabolic risk factors in a multiethnic group of women with PCOS studied in Denmark

Diverse impacts of aging on insulin resistance in lean and obese women with polycystic ovary syndrome: evidence from 1345 women with the syndrome

A rational approach to the diagnosis of polycystic ovarian syndrome during adolescence

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