Defining Conditions for Optimal Inhibition of Food Intake in Rats by a Grape-Seed Derived Proanthocyanidin Extract

Serrano, Joan; Casanova-Martí, Àngela; Blay, Mayte; Terra, Ximena; Ardèvol, Anna; Pinent, Montserrat

doi:10.3390/nu8100652

Cited by 16 publications

(18 citation statements)

References 57 publications

(83 reference statements)

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“…Working with doses around 500 mg GSPE/kg b.w., a non-dietary dose, we showed that a dose of least 350 mg GSPE/kg b.w. is necessary to obtain satiating effects simultaneously to lipolytic action after 8–10 days of subchronic treatment [ 29 ]. Bao and colleagues proposed a minimum dose of 250 mg/kg, administered for 16 weeks, to obtain effects on body weight and also satiety, in a Diabetes Mellitus 1 model [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Summarizing all the considered aspects regarding the different administration time points of a GSPE dose of 500 mg/kg b.w., we can define the most optimal approach for using GPSE as an agent to avoid unhealthy states related to obesity. We have previously discarded the use of higher doses because they can produce negative effects [ 29 ], some of them related to desensitization to enterohomone signaling [ 40 ]. Dietary doses need to be used from the beginning of the challenge to produce the most effective results [ 7 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

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Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats

et al. 2018

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Obesity is highly associated with the pathologies included in the concept of the Metabolic Syndrome. Grape-seed proanthocyanins (GSPE) have showed very positive effects against all these metabolic disruptions; however, there is, as yet, no consensus about their effectiveness against an obesogenic challenge, such as a cafeteria diet. We determined the effectiveness of a dose of 500 mg GSPE/kg b.w. (body weight) against the obesogenic effects of a 17-week cafeteria diet, administered as a sub-chronic treatment, 10–15 days before, intermittently and at the end of the diet, in Wistar rats. Body weight, adiposity, indirect calorimetry and plasma parameters were analyzed. GSPE pre-treatment showed a long-lasting effect on body weight and adiposity that was maintained for seven weeks after the last dose. A corrective treatment was administered for the last two weeks of the cafeteria diet intervention; however, it did not effectively correct any of the parameters assessed. The most effective treatment was an intermittent GSPE dosage, administered every second week during the cafeteria diet. This limited body weight gain, adiposity and most lipotoxic effects. Our results support the administration of this GSPE dose, keeping an intermittent interval between dosages longer than every second week, to improve obesogenic disruptions produced by a cafeteria diet.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats

et al. 2018

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“…In the central nervous system, the level of GLP-1 in plasma was elevated by giving 1 g GSPE/kg to fasting rats [93]. GLP-1 is a peptide hormone coded by the human glucagon gene Fig.…”

Section: Reduce Food Intakementioning

confidence: 99%

Effects of Grape Seed Proanthocyanidin Extract on Obesity

Liu

Peng

et al. 2020

Obes Facts

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Obesity is a chronic metabolic disease resulting from excessive fat accumulation and/or abnormal distribution caused by multiple factors. As a major component of metabolic syndrome, obesity is closely related to many diseases such as type 2 diabetes mellitus, hyperlipidemia, hypertension, coronary heart disease, stroke and cancer. Hence, the problem of obesity cannot be ignored, and recent studies have shown that grape seed proanthocyanidin extract (GSPE) has an antiobesity effect. This paper systematically reviews the research progress and potential mechanism of GSPE emphasizing on obesity prevention and treatment.has increased from 105 million in 1975 to 641 million in 2014 [8]. In a nutshell, obesity poses a serious threat to the health of individuals, and more and more evidence shows that obesity is an important risk factor affecting the morbidity and mortality in cardiovascular diseases; also, overweight can increase the mortality of adults suffering from cardiovascular diseases [9]. The body mass index has a linear relationship with the mortality rate of coronary artery disease, stroke and diabetes mellitus [10]. Even modest weight loss can also reduce the risk of these complications [11]. In addition, obesity can lead to gastrointestinal disorders, joint and muscle diseases, respiratory system problems and psychological problems [12,13]. In short, obesity is an increasingly serious global public health problem, which seriously affects the daily life of obese people and increases the risk of mortality.How to prevent and treat obesity has been the focus of attention. Behavioral exercise and drug therapy [14], surgical weight loss [15] and dietary intervention therapy [16] have been the focus of research. But the effect of behavioral exercise on weight loss is slow and obviously unsuitable for obese patients with cardiovascular diseases; every weight loss drug has its own unique risk characteristics, so the doctor needs to fully understand drug contraindications and the differences among obese individuals [17]. More importantly, there is still a lack of long-term experimental studies on whether drug weight loss can cause side effects. Besides, the way of surgical weight loss has been considered controversial for a long time. It can reduce obesity in a short period of time, as 10-30% of patients who undergo gastric bypass surgery lose weight by 40 or 50% [18]. However, current evidence shows that the benefits of surgical weight loss are not universal. A considerable proportion of patients will experience weight rebound and recurrence of diabetes [19]. Although exercise, drugs and surgery can achieve effective weight loss, they have limitations, risks and instability, and are not suitable for all obese patients. In this context, a safe and reliable method of reducing obesity with fewer side effects is urgently required by obese people. Compared with behavior, drugs and surgical treatment, dietary strategies for losing weight or improving obesity-related conditions seem to be more anticipated. The use of plant-d...

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“…Serrano et al showed that a dose of 500 mg/kg bw of a grape-seed proanthocyanidin extract (GSPE) was able to limit food intake [22], modify enteroendocrine hormone secretions [23], and decrease gastric emptying in female rats, thus inducing a satiating effect [24]. Moreover, the authors suggested that GSPE acts on food intake and body weight through vagal GLP-1 receptor (GLP-1R) activation on the hypothalamic centre of food intake control and GLP-1 production in the intestine [25]. Similarly, puerarin, a dietary isoflavone, improves glucose homeostasis in obese diabetic mice and protects pancreatic β-cell survival by mechanisms that involve the activation of GLP-1R signaling and downstream targets [26].…”

Section: Introductionmentioning

confidence: 99%

Long-Lasting Effects of GSPE on Ileal GLP-1R Gene Expression Are Associated with a Hypomethylation of the GLP-1R Promoter in Female Wistar Rats

et al. 2019

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Flavonoids have been shown to modulate GLP-1 in obesity. GLP-1 induces some of its effects through the intestinal GLP-1 receptor (GLP-1R), though no data exist on how flavonoids affect this receptor. Here, we examine how a dose of grape seed proanthocyanidin extract (GSPE) with anti-obesity activity affects intestinal GLP-1R and analyze whether epigenetics play a role in the long-lasting effects of GSPE. We found that 10-day GSPE administration prior to the cafeteria diet upregulated GLP-1R mRNA in the ileum 17 weeks after the GSPE treatment. This was associated with a hypomethylation of the GLP-1R promoter near the region where the SP1 transcription factor binds. In the colon, the cafeteria diet upregulated GLP-1R without showing any GSPE effect. In conclusion, we have identified long-lasting GSPE effects on GLP-1R gene expression in the ileum that are partly mediated by hypomethylation at the gene promoter and may affect the SP1 binding factor.

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Defining Conditions for Optimal Inhibition of Food Intake in Rats by a Grape-Seed Derived Proanthocyanidin Extract

Cited by 16 publications

References 57 publications

Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats

Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats

Effects of Grape Seed Proanthocyanidin Extract on Obesity

Long-Lasting Effects of GSPE on Ileal GLP-1R Gene Expression Are Associated with a Hypomethylation of the GLP-1R Promoter in Female Wistar Rats

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