Defining blood hematology reference values in female pig‐tailed macaques (Macaca nemestrina) using the Isolation Forest algorithm
Daniel Kim,
Abigail Derton,
George Khalil
et al.
Abstract:BackgroundPig‐tailed macaques (PTMs) are commonly used as preclinical models to assess antiretroviral drugs for HIV prevention research. Drug toxicities and disease pathologies are often preceded by changes in blood hematology. To better assess the safety profile of pharmaceuticals, we defined normal ranges of hematological values in PTMs using an Isolation Forest (iForest) algorithm.MethodsEighteen female PTMs were evaluated. Blood was collected 1–24 times per animal for a total of 159 samples. Complete blood… Show more
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