Defining atherosclerotic plaque biology by mass spectrometry-based omics approaches

Chandran, Mahesh; Sudhina, S.; Abhirami,; Chandran, Akash M.; Jaleel, Abdul; Ayyappan, Janeesh Plakkal

doi:10.1039/d2mo00260d

Cited by 4 publications

(1 citation statement)

References 149 publications

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“…Atherogenesis begins with the accumulation of lipoproteins, in particular LDL in the subendothelial space [ 13 , 14 ]. In the inner intimal layer, oxidized LDL act as the chronic stimulators of innate and adaptive immune responses [ 11 , 15 ], while activated ECs and vascular smooth muscle cells (VSMCs) express adhesion molecules, chemoattractants and growth factors interacting with monocyte receptors, stimulating their homing, migration and differentiation into macrophages and dendritic cells [ 13 ].…”

Section: Pathophysiology Of Coronary Atherosclerotic Diseasementioning

confidence: 99%

Intracoronary Imaging of Coronary Atherosclerotic Plaque: From Assessment of Pathophysiological Mechanisms to Therapeutic Implication

Gurgoglione

Denegri

Russo

et al. 2023

IJMS

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Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality worldwide. Several cardiovascular risk factors are implicated in atherosclerotic plaque promotion and progression and are responsible for the clinical manifestations of coronary artery disease (CAD), ranging from chronic to acute coronary syndromes and sudden coronary death. The advent of intravascular imaging (IVI), including intravascular ultrasound, optical coherence tomography and near-infrared diffuse reflectance spectroscopy has significantly improved the comprehension of CAD pathophysiology and has strengthened the prognostic relevance of coronary plaque morphology assessment. Indeed, several atherosclerotic plaque phenotype and mechanisms of plaque destabilization have been recognized with different natural history and prognosis. Finally, IVI demonstrated benefits of secondary prevention therapies, such as lipid-lowering and anti-inflammatory agents. The purpose of this review is to shed light on the principles and properties of available IVI modalities along with their prognostic significance.

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