Defining Antibody Seroprevalence and Duration of Humoral Responses to SARS-CoV-2 Infection and/or Vaccination in a Greek Community

Kotsiou, Ourania S.; Papagiannis, Dimitrios; Fradelos, Εvangelos C.; Siachpazidou, Dimitra; Perlepe, Garyfallia; Miziou, Angeliki; Kyritsis, Athanasios P.; Vavougios, George D.; Kalantzis, George; Gourgoulianis, Konstantinos

doi:10.3390/ijerph19010407

Cited by 2 publications

(5 citation statements)

References 31 publications

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“…Higher antibody titers were found in cases of vaccination in previously infected subjects, according to a previous study by our scientific team [4,5]. This finding is also supported by many other studies which report that a low concentration of SARS-CoV-2 spike protein antibodies after 9-12 months indicates that re-exposure to the virus or vaccination is required to use the B-cell immunity to full capacity [22].…”

Section: Discussionsupporting

confidence: 84%

“…The longevity of the antibody response to the SARS-CoV-2 infection are not well defined. We have recently reported that antibody responses to the SARS-CoV-2 infection were maintained nine months after the pandemic and especially in those with severe disease leading to hospitalization [4,5]. A recent study identified the over one year duration of SARS-CoV-2 antibodies in 82.90% of 538 convalescent COVID-19 patients [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…The SARS-CoV-2 IgG II Quant method (Architect, Abbott, IL, USA) was used for antibody testing. This is an automated two-step chemiluminescent microparticle immunoassay that was used for the qualitative and quantitative determination of IgG antibodies against the spike receptor-binding domain (RBD) of SARS-CoV-2 in the serum specimens, with a sensitivity of 99.9% and specificity of 100% for detecting the IgG antibodies generated by prior infection or vaccination, as previously described [4,5]. The sequence used for the receptor-binding domain was taken from the WH-Human 1 coronavirus, GenBank accession number MN908947.…”

Section: Methodsmentioning

confidence: 99%

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The Comparative Superiority of SARS-CoV-2 Antibody Response in Different Immunization Scenarios

Kotsiou

Karakousis²,

Papagiannis

et al. 2022

JPM

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Background: Both SARS-CoV-2 infection and/or vaccination result in the production of SARS-CoV-2 antibodies. We aimed to compare the antibody titers against SARS-CoV-2 in different scenarios for antibody production. Methods: A surveillance program was conducted in the municipality of Deskati in January 2022. Antibody titers were obtained from 145 participants while parallel recording their infection and/or vaccination history. The SARS-CoV-2 IgG II Quant method (Architect, Abbott, IL, USA) was used for antibody testing. Results: Advanced age (>56 years old) was associated with higher antibody titers. No significant differences were detected in antibody titers among genders, BMI, smoking status, comorbidities, vaccine brands, and months after the last dose. Hospitalization length and re-infection were predictors of antibody titers. The individuals who were fully or partially vaccinated and were also double infected had the highest antibody levels (25,017 ± 1500 AU/mL), followed by people who were fully vaccinated (20,647 ± 500 AU/mL) or/partially (15,808 ± 1800 AU/mL) vaccinated and were infected once. People who were only vaccinated had lower levels of antibodies (9946 ± 300 AU/mL), while the lowest levels among all groups were found in individuals who had only been infected (1124 ± 200 AU/mL). Conclusions: Every hit (infection or vaccination) gives an additional boost to immunization status.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The Comparative Superiority of SARS-CoV-2 Antibody Response in Different Immunization Scenarios

Kotsiou

Karakousis²,

Papagiannis

et al. 2022

JPM

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“…Vaccination alone generated an immune response in almost half of the population in this community. We found higher antibody titers in the case of vaccination in previously infected subjects than in unvaccinated ones [3]. In this direction, it has been shown that the antibody response to the first vaccine dose was almost twofold higher in individuals who were seropositive before vaccination compared to those who were seronegative, suggesting that prior infection primes the immune response to the first dose of mRNA-based vaccine [4].…”

Section: Introductionmentioning

confidence: 50%

“…In our previous studies, we showed that SARS-CoV-2 seropositivity approached 45% in high-burden contexts of COVID-19 in Greece after the easing of measures during the second pandemic wave in November 2020, which was exclusively attributed to humoral immunity [2]. Notably, when the vaccination strategy was included nine months after this pandemic wave, SARS-CoV-2 seropositivity was increased to 76% [3]. Vaccination alone generated an immune response in almost half of the population in this community.…”

Section: Introductionmentioning

confidence: 92%

Lessons We Have Learned Regarding Seroprevalence in High and Low SARS-CoV-2 Contexts in Greece before the Omicron Pandemic Wave

Kotsiou

Vavougios

Papagiannis

et al. 2022

IJERPH

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Background: Antibody seroprevalence in rural communities remains poorly investigated. We compared the SARS-CoV-2 seroprevalence in two Greek communities in June and July 2021 after the end of the Delta-driven pandemic wave that started in November 2020. One community was affected worse than the other. Methods: The SARS-CoV-2 IgG II Quant method (Architect, Abbott, IL, USA) was used for antibody testing. Results: We found a high rate of SARS-CoV-2 seropositivity in both communities, approaching 77.5%. In the area with a higher burden of COVID-19, Malesina, seropositivity was achieved with vaccine-acquired and naturally acquired immunity, whereas in the low-burden context of Domokos, the high rates of seropositivity were achieved mainly with vaccination. Previously infected individuals were less likely to be vaccinated than previously uninfected adults. The antibody titers were significantly higher in previously infected, vaccinated participants than in unvaccinated ones. In total, 4% and 10% of the unvaccinated population were diagnosed seropositive for the first time while not knowing about the previous infection. Age and gender did not impact antibody titers in high- or low-burden contexts. Conclusions: Before the Omicron pandemic wave, herd immunity was reached in different contexts in Greece. Higher antibody titers were measured in infected vaccinated individuals than in infected unvaccinated ones.

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Defining Antibody Seroprevalence and Duration of Humoral Responses to SARS-CoV-2 Infection and/or Vaccination in a Greek Community

Cited by 2 publications

References 31 publications

The Comparative Superiority of SARS-CoV-2 Antibody Response in Different Immunization Scenarios

The Comparative Superiority of SARS-CoV-2 Antibody Response in Different Immunization Scenarios

Lessons We Have Learned Regarding Seroprevalence in High and Low SARS-CoV-2 Contexts in Greece before the Omicron Pandemic Wave

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