Defining a Role of Amanita phalloides Toxins in Cancer: Research and Therapy

Abstract

Despite the progress of diagnostic and therapy, the cancer burden is still rising worldwide. The new chemotherapeutical toxicity to somatic cells and its tolerance to tumor cells illustrates the immediate demand through recent pharmaceutical products with less harmful impacts. The use of natural anticancer products, like alpha-amanitin toxins have reached the cancer field therapy since the separation of Amanita phalloides fungi was performed. Application of Amanita phalloides affects tumor cell activity. It is thought that Amanita phalloides dilutions are recommended for a patient suffering from various cancer types and have no severe side effects resulting from amanita therapy. This review aims to explain the use of the therapeutic potential of -amanitin toxin against different cancer types.