Deficits in Functional Connectivity of Hippocampal and Frontal Lobe Circuits After Traumatic Axonal Injury

Plata, Carlos D. Marquez de la; Garces, Juanita; Shokri‐Kojori, Ehsan; Grinnan, Jack; Krishnan, K. Ranga; Pidikiti, Rajesh; Spence, Jeffrey S.; Devous, Michael D.; Moore, Carol; McColl, Roderick W; Madden, Christopher J.

doi:10.1001/archneurol.2010.342

Cited by 105 publications

(75 citation statements)

References 48 publications

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“…6 In addition, restingstate fMRI studies involving magnetoencephalographic recordings have also provided evidence of brain plasticity and network reorganization mechanisms, specifically increases or decreases in the extent of certain brain connections.…”

Section: Discussionmentioning

confidence: 99%

Resting-State Functional Magnetic Resonance Imaging Activity and Connectivity and Cognitive Outcome in Traumatic Brain Injury

Palacios¹,

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Resting-State Functional Magnetic Resonance Imaging Activity and Connectivity and Cognitive Outcome in Traumatic Brain Injury

Palacios¹,

et al. 2013

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“…A previous study performed whole-brain connectivity analyses with bilateral hippocampi as seeds, but only visually compared group-averaged maps of whole-brain connectivity, precluding inferences about group differences in connectivity magnitude. 76 In the current investigation, we used direct comparisons between groups to show that TBI results in increased synchrony of the hippocampi with relatively proximal regions (e.g., in parts of the anterior MTL, parahippocampal gyrus, insula, and brainstem) and a reduction in antiphase synchrony between hippocampus and task-positive regions, particularly the PFC, compared to controls. Further, longitudinal results indicate that both of these effects emerge relatively early after injury, with hypersynchrony progressing from a uni-to a bilateral phenomenon.…”

Section: Development Of Hippocampal Connectivity Alterationsmentioning

confidence: 99%

Chronology and Chronicity of Altered Resting-State Functional Connectivity after Traumatic Brain Injury

Venkatesan

Dennis

Hillary

2015

Journal of Neurotrauma

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Whereas traumatic brain injury (TBI) results in widespread disruption of neural networks, changes in regional resting-state functional connectivity patterns after insult remain unclear. Specifically, little is known about the chronology of emergent connectivity alterations and whether they persist after a critical recovery window. We used resting-state functional magnetic resonance imaging and seed-voxel correlational analyses in both cross-sectional and longitudinal designs to probe intrinsic connectivity patterns involving the posterior cingulate cortex (PCC) and hippocampi, regions shown to be important in the default mode network (DMN) and vulnerable to neuropathology. A total of 22 participants in the chronic stage of moderateto-severe TBI and 18 healthy controls were included for cross-sectional study. Longitudinal analyses included 13 individuals in the TBI group for whom data approximately 3 months after injury (subacute) were available. Overall, results indicated dissociable connectivity trajectories of the PCC and hippocampi during recovery from TBI, with PCC alterations characterized by early hypersynchrony with the anterior DMN that is gradually reduced, and hippocampal changes marked by increasing synchrony with proximal cortex and subcortex. The PCC also showed increasing antiphase synchrony with posterior attentional regions, and the hippocampi showed decreasing antiphase synchrony with frontal attentional regions. Antiphase synchrony of the hippocampus and dorsolateral prefrontal cortex at the subacute stage of TBI was positively associated with attentional performance on neuropsychological tests at both the subacute and chronic stages. Our findings highlight the heterogeneity of regional whole-brain connectivity changes after TBI, and suggest that residual connectivity alterations exist in the clinically stable phase of TBI. Parallels between the chronicity of the observed effects and findings in neurodegenerative disease are discussed in the context of potential long-term outcomes of TBI.

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“…and 2) by applying independent components analysis (ICA) (Calhoun et al, 2002) to look for connectivity within different areas of the brain. Functional connectivity has been recently applied in both mild TBI (Mayer et al, 2011) and more severe TBI (Marquez de la Plata et al, 2011) and understanding the coherence of functional networks may provide important insights into recovery and therapeutic interventions. Graph theory has also now been applied to this area of research.…”

Section: Perfusion Imagingmentioning

confidence: 99%

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Hunter

Wilde

Tong

et al. 2012

Journal of Neurotrauma

113

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This article identifies emerging neuroimaging measures considered by the inter-agency Pediatric Traumatic Brain Injury (TBI) Neuroimaging Workgroup. This article attempts to address some of the potential uses of more advanced forms of imaging in TBI as well as highlight some of the current considerations and unresolved challenges of using them. We summarize emerging elements likely to gain more widespread use in the coming years, because of 1) their utility in diagnosis, prognosis, and understanding the natural course of degeneration or recovery following TBI, and potential for evaluating treatment strategies; 2) the ability of many centers to acquire these data with scanners and equipment that are readily available in existing clinical and research settings; and 3) advances in software that provide more automated, readily available, and cost-effective analysis methods for large scale data image analysis. These include multi-slice CT, volumetric MRI analysis, susceptibility-weighted imaging (SWI), diffusion tensor imaging (DTI), magnetization transfer imaging (MTI), arterial spin tag labeling (ASL), functional MRI (fMRI), including resting state and connectivity MRI, MR spectroscopy (MRS), and hyperpolarization scanning. However, we also include brief introductions to other specialized forms of advanced imaging that currently do require specialized equipment, for example, single photon emission computed tomography (SPECT), positron emission tomography (PET), encephalography (EEG), and magnetoencephalography (MEG)/magnetic source imaging (MSI). Finally, we identify some of the challenges that users of the emerging imaging CDEs may wish to consider, including quality control, performing multi-site and longitudinal imaging studies, and MR scanning in infants and children.

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Deficits in Functional Connectivity of Hippocampal and Frontal Lobe Circuits After Traumatic Axonal Injury

Cited by 105 publications

References 48 publications

Resting-State Functional Magnetic Resonance Imaging Activity and Connectivity and Cognitive Outcome in Traumatic Brain Injury

Resting-State Functional Magnetic Resonance Imaging Activity and Connectivity and Cognitive Outcome in Traumatic Brain Injury

Chronology and Chronicity of Altered Resting-State Functional Connectivity after Traumatic Brain Injury

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

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