Deficits in face perception in the amnestic form of mild cognitive impairment

Lim, Tae Sung; Lee, Hyun Young; Barton, Jason J.S.; Moon, So Young

doi:10.1016/j.jns.2011.07.001

Cited by 8 publications

(14 citation statements)

References 52 publications

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“…Studies with face matching tasks in MCI subjects suggested no differences in the number of correct answers, but only longer completion time when compared to normal controls [21], [22]. This is consistent with our results where no impairment of FFI compared to controls was found in any of the aMCI subtype and both, SD-aMCI as well as MD-aMCI group, performed similarly when compared with each other.…”

Section: Discussionsupporting

confidence: 91%

“…Spreading of the pathology beyond the mesiotemporal structures in subjects with dementia would correspond to our observation that FFI impairment relying on more lateral regions within temporal neocortex [17], [21] was present together with FLI and FER impairment only in demented subjects.…”

Section: Discussionsupporting

confidence: 82%

“…According to the literature the FLI, FER and FFI depends on various anatomical structures [17], [21], [30], [31], [32], [54] therefore the differences in the impairment of specific domains among the groups of patients with different severity of cognitive impairment might be caused by distinct neuropathological correlates involved in each paradigm. According to Braak and Braak [35], underlying AD pathology spreads gradually; affecting medio-temporal structures in the typical order and clinical staging corresponds with tau pathology and Braak staging [34].…”

Section: Discussionmentioning

confidence: 99%

“…Studies on famous faces identification (FFI) report consistently impairment of this domain in subjects with dementia due to AD [18], [19], [20] while studies with MCI subjects report rather inhomogeneous results [15], [16], [21], [22].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, these studies use different paradigms exploring each specific domain. Some studies rely on testing the naming of famous faces/objects which also involves some semantic processing [15], [16] while others use face matching tasks, comparing similarities or differences in facial features or emotions [17], [21], [22].…”

Section: Introductionmentioning

confidence: 99%

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Famous Landmark Identification in Amnestic Mild Cognitive Impairment and Alzheimer's Disease

et al. 2014

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BackgroundIdentification of famous landmarks (FLI), famous faces (FFI) and recognition of facial emotions (FER) is affected early in the course of Alzheimer's disease (AD). FFI, FER and FLI may represent domain specific tasks relying on activation of distinct regions of the medial temporal lobe, which are affected successively during the course of AD. However, the data on FFI and FER in MCI are controversial and FLI domain remains almost unexplored.ObjectivesTo determine whether and how are these three specific domains impaired in head to head comparison of patients with amnestic MCI (aMCI) single domain (SD-aMCI) and multiple domain (MD-aMCI). We propose that FLI might be most reliable in differentiating SD-aMCI, which is considered to be an earlier stage of AD pathology spread out, from the controls.Patients and MethodsA total of 114 patients, 13 with single domain (SD–aMCI) and 30 with multiple domains (MD–aMCI), 29 with mild AD and 42 controls underwent standard neurological and neuropsychological evaluations as well as tests of FLI, FER and FFI.ResultsCompared to the control group, AD subjects performed worse on FFI (p = 0.020), FER (p<0.001) and FLI (p<0.001), MD-aMCI group had significantly worse scores only on FLI (p = 0.002) and approached statistical significance on FER (0.053). SD-aMCI group performed significantly worse only on FLI (p = 0.028) compared to controls.ConclusionsPatients with SD-aMCI had an isolated impairment restricted to FLI, while patients with MD–aMCI showed impairment in FLI as well as in FER. Patients with mild dementia due to AD have more extensive impairment of higher visual perception. The results suggest that FLI testing may contribute to identification of patients at risk of AD. We hypothesize that clinical examination of all three domains might reflect the spread of the disease from transentorhinal cortex, over amygdala to fusiform gyrus.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Famous Landmark Identification in Amnestic Mild Cognitive Impairment and Alzheimer's Disease

et al. 2014

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Eye movement patterns during viewing face images with neutral expressions in patients with early‐stage Alzheimer's disease and amnestic mild cognitive impairment

Eraslan Boz,

Koçoğlu,

Akkoyun

et al. 2023

Brain and Behavior

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BackgroundAlzheimer’s disease (AD) neuropathology affects the brain regions responsible for visuospatial skills. Accumulating evidence points to visual difficulties involving face processing in AD and amnestic mild cognitive impairment (aMCI). No study has so far examined eye movement patterns when viewing faces with neutral expressions in patients with AD.AimThe objective of this study aimed to examine the eye movements of patients with early‐stage AD, aMCI, and healthy controls (HC) during viewing face images.Materials&MethodsThirty‐one AD, 37 aMCI, and 33 HC were included in the study. Eye movements in facial stimuli were recorded with the EyeLink 1000 Plus eye‐tracker.ResultsOur findings showed that AD patients looked less at the eye area of interest than the nose and mouth areas of interest compared to aMCI and HC. Regardless of the group, all participants looked at the eye and nose areas of interest more and longer in the mouth area of interest. In addition, the first fixation duration to the eye area of interest of all participants was shorter than that of the nose and mouth.DiscussionConsistent with our study, studies in healthy adults revealed eye movement patterns that focused more on the eyes and nose. AD patients are unable to pay attention to the salient parts of faces, tending to focus instead on the non‐informative parts.ConclusionOur study is the first to reveal eye movement differences in face processing in AD.

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Specific and disease stage-dependent episodic memory-related brain activation patterns in Alzheimer’s disease: a coordinate-based meta-analysis

et al. 2014

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Episodic memory is typically affected during the course of Alzheimer's disease (AD). Due to the pronounced heterogeneity of functional neuroimaging studies on episodic memory impairments in mild cognitive impairment (MCI) and AD regarding their methodology and findings, we aimed to delineate consistent episodic memory-related brain activation patterns. We performed a systematic, quantitative, coordinate-based whole-brain activation likelihood estimation meta-analysis of 28 functional magnetic resonance imaging (fMRI) studies comprising 292 MCI and 102 AD patients contrasted to 409 age-matched control subjects. We included episodic encoding and/or retrieval phases, investigated the effects of group, verbal or image stimuli and correlated mean Mini-Mental-Status-Examination (MMSE) scores with the modelled activation estimates. MCI patients presented increased right hippocampal activation during memory encoding, decreased activation in the left hippocampus and fusiform gyrus during retrieval tasks, as well as attenuated activation in the right anterior insula/inferior frontal gyrus during verbal retrieval. In AD patients, however, stronger activation within the precuneus during encoding tasks was accompanied by attenuated right hippocampal activation during retrieval tasks. Low cognitive performance (MMSE scores) was associated with stronger activation of the precuneus and reduced activation of the right (para)hippocampus and anterior insula/inferior frontal gyrus. This meta-analysis provides evidence for a specific and probably disease stage-dependent brain activation pattern related to the pathognomonic AD characteristic of episodic memory loss.

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Deficits in face perception in the amnestic form of mild cognitive impairment

Cited by 8 publications

References 52 publications

Famous Landmark Identification in Amnestic Mild Cognitive Impairment and Alzheimer's Disease

Famous Landmark Identification in Amnestic Mild Cognitive Impairment and Alzheimer's Disease

Eye movement patterns during viewing face images with neutral expressions in patients with early‐stage Alzheimer's disease and amnestic mild cognitive impairment

Specific and disease stage-dependent episodic memory-related brain activation patterns in Alzheimer’s disease: a coordinate-based meta-analysis

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