Deficits in Early Sensory and Cognitive Processing Are Related to Phase and Nonphase EEG Activity in Multiple Sclerosis Patients

Sarrias-Arrabal, Esteban; Eichau, Sara; Galvao-Carmona, Alejandro; Dominguez, E. Delgado; Izquierdo, Guillermo; Vázquez‐Marrufo, Manuel

doi:10.3390/brainsci11050629

Cited by 6 publications

(8 citation statements)

References 62 publications

(125 reference statements)

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“…A visual task was performed by the participants during which a time–frequency analysis of electroencephalography (EEG) had been performed simultaneously. Reaction time and accuracy were worse in MS patients in comparison to healthy controls and delay in latency and lower amplitude in MS patients in evoked and induced alpha compared to the control group were observed in EEG, which suggested deficits in early sensorial and cognitive processing [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Sensory Integration Disorders in Patients with Multiple Sclerosis

Mross

Jankowska

Meller

et al. 2022

JCM

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Sensory integration disorder (SID) is also called, interchangeably, sensory processing disorder (SPD). Multiple sclerosis (MS) is an autoimmune, chronic, neurological disease of the central nervous system. Sensorimotor function disorders are present in both multiple sclerosis and SID. The study aimed to assess the SID among patients with MS and included 141 patients with relapse-remitting MS and 72 participants in the control group. To assess SID in both groups, a questionnaire prepared by Daniel Travis was used. Additionally, participants answered questions regarding their age, gender, handedness and in the study group about the duration of the disease, relapses in the past year and the advancement of the disease using EDSS. The occurrence of sensory seeking was significantly more frequent in the MS patients with relapses in the past year. Patients with MS had more often general disorders of sensory integration in the past. However, healthy subjects significantly more often showed the severity of social and emotional disorders in the past. Currently, the group of MS patients has a greater intensity of sensor-based motor abilities. The study revealed more severe SID in MS patients than in the control group. Still, more research is needed in this field.

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Section: Introductionmentioning

confidence: 99%

Sensory Integration Disorders in Patients with Multiple Sclerosis

Mross

Jankowska

Meller

et al. 2022

JCM

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“…One of these methods is the temporal spectral evolution (TSE) 5 , 6 . The TSE obtains information about phase-locked and nonphase-locked activity 3 .TSE has been scarcely applied, but it has provided interesting results in healthy and pathological populations 7 – 10 . The TSE has shown altered or compensatory mechanisms hidden from the phase-locked parameters 7 – 12 .…”

Section: Introductionmentioning

confidence: 99%

Effect of the side of presentation in the visual field on phase-locked and nonphase-locked alpha and gamma responses

Sarrias-Arrabal

Martı́n-Clemente

Galvao-Carmona

et al. 2022

Sci Rep

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Recent studies have suggested that nonphase-locked activity can reveal cognitive mechanisms that cannot be observed in phase-locked activity. In fact, we describe a concomitant decrease in nonphase-locked alpha activity (desynchronization) when stimuli were processed (alpha phase-locked modulation). This desynchronization may represent a reduction in “background activity” in the visual cortex that facilitates stimulus processing. Alternatively, nonphase-locked gamma activity has been hypothesized to be an index of shifts in attentional focus. In this study, our main aim was to confirm these potential roles for nonphase-locked alpha and gamma activities with a lateralized Go/NoGo paradigm. The results showed that nonphase-locked alpha modulation is bilaterally represented in the scalp compared to the contralateral distribution of the phase-locked response. This finding suggests that the decrease in background activity is not limited to neural areas directly involved in the visual processing of stimuli. Additionally, gamma activity showed a higher desynchronization of nonphase-locked activity in the ipsilateral hemisphere, where the phase-locked activity reached the minimum amplitude. This finding suggests that the possible functions of nonphase-locked gamma activity extend beyond shifts in attentional focus and could represent an attentional filter reducing the gamma representation in the visual area irrelevant to the task.

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“…It is true that using techniques such as the FFT, it is possible to observe increases or decreases in the power of the spectral activity, but it is not possible to discern whether the observed increase or decrease occurs in phase or non-phase activity. In fact, previous studies have shown that non-phase alpha activity may represent a decrease in neural noise to allow other processes operating in other bands to be executed (Sarrias-Arrabal et al 2021 ; Vázquez-Marrufo et al 2019 , 2020a ). Nevertheless, induced pre-stimulus (non-phase) activity has hardly been analyzed by TSE.…”

Section: Introductionmentioning

confidence: 99%

“…(pN, BP, and vN), suggesting unknown mechanisms for traditional analyses (evoked and phase activity)(Di Russo et al 2020;Ragazzoni et al 2019;Sarrias-Arrabal et al 2021; Va ´zquez-Marrufo et al 2020b). For instance, induced delta and induced theta activity showed modulations (desynchronization) within the temporal range of pN and BP components in anterior and central areas but not in parieto-occipital areas.…”

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confidence: 99%

Temporal spectral evolution of pre-stimulus brain activity in visual and visuomotor tasks

et al. 2022

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The aim of this study was to describe the spectral features of pre-stimulus event-related potential (ERP) components elicited in visual tasks such as the Bereitschaftspotential (BP), prefrontal negativity (pN) and visual negativity (vN). ERPs are considered time-locked and phase-locked (evoked) activity, but we have also analyzed the non-phase but time-locked (induced) activity in the same interval by applying the temporal spectral evolution (TSE) method. Participants (N = 26) were tested in a passive task, a simple response task (SRT) and a discriminative response task (DRT), where EEG activity was recorded with 64 scalp electrodes. We analyzed the time-frequency modulations (phase and non-phase) prior to the onset of the stimuli in the sub-delta, delta, theta, alpha, beta, and gamma frequency bands. The results showed that all the pre-stimulus ERP components were mainly regulated by evoked activity in the sub-delta band. On the other hand, induced activity seems to be linked to evoked responses but with a different psychophysiological role. We concluded that other preparatory cognitive mechanisms associated with ERPs can also be detected by the TSE method. This finding may suggest underlying mechanisms in non-phase activity and requires the addition of non-phase activity analysis to the traditional analysis (phase and evoked activity).

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Deficits in Early Sensory and Cognitive Processing Are Related to Phase and Nonphase EEG Activity in Multiple Sclerosis Patients

Cited by 6 publications

References 62 publications

Sensory Integration Disorders in Patients with Multiple Sclerosis

Sensory Integration Disorders in Patients with Multiple Sclerosis

Effect of the side of presentation in the visual field on phase-locked and nonphase-locked alpha and gamma responses

Temporal spectral evolution of pre-stimulus brain activity in visual and visuomotor tasks

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