Deficits in complex visual information processing after mild TBI: Electrophysiological markers and vocational outcome prognosis

Lachapelle, Julie; Bolduc-Teasdale, Julie; Ptito, Alain; McKerral, Michelle

doi:10.1080/02699050801938983

Cited by 56 publications

(34 citation statements)

References 67 publications

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“…[4][5][6][7][8] For example, a long-term analysis of visual event-related potentials (VERPs) in 17 patients with TBI reported deficits in complex visual integrative tests. 9 Further, reduced amplitude and delayed latency of VERPs have been observed in patients with moderate TBI. 10 Often, blast injury is comorbid with other types of injury such as blunt injury.…”

Section: Discussionmentioning

confidence: 99%

Retinal Ganglion Cell Damage in an Experimental Rodent Model of Blast-Mediated Traumatic Brain Injury

Mohan

Kecova

Hernandez-Merino

et al. 2013

Invest. Ophthalmol. Vis. Sci.

115

161

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Section: Discussionmentioning

confidence: 99%

Retinal Ganglion Cell Damage in an Experimental Rodent Model of Blast-Mediated Traumatic Brain Injury

Mohan

Kecova

Hernandez-Merino

et al. 2013

Invest. Ophthalmol. Vis. Sci.

115

161

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“…9,19,23,25,26,31,46 Moreover, abnormal ERP components were found even when concussed athletes did not report symptoms. 23,32,45,46 Taken together, ERP studies have shown that MTBI and sports concussion produce mild but persistent cerebral changes that can be observed even when patients are asymptomatic.…”

Section: Event-related Potentials Mtbi and Concussionmentioning

confidence: 99%

Evaluating the cognitive consequences of mild traumatic brain injury and concussion by using electrophysiology

Gosselin

Bottari

Chen

et al. 2012

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Object Mild traumatic brain injury (MTBI), often referred to as concussion when it occurs in sports, produces persistent cognitive problems in at least 15% of patients. Unfortunately, conventional neuropsychological tests usually yield results within normal limits in this population. The main objective of this event-related potential (ERP) study was to understand brain functioning during the performance of a working memory (WM) task in patients who have sustained an MTBI, mostly due to motor vehicle accident or sports concussion. This study also aimed for a better understanding of the association between brain functioning as measured with ERP, behavioral performance on the WM task, postconcussion symptoms, type of injury (that is, sports concussion vs other types), and time since the injury. Methods Forty-four patients with MTBI (7.6 ± 8.4 months postinjury) were tested on a visual WM task with simultaneous recording of ERP, and were compared with 40 control volunteers who were their equivalent for age and sex. Amplitude and latency of frontal (N200 and N350) and parietal (P200 and P300) ERP waves were measured and were compared between groups. Correlation analyses were also performed between ERP characteristics, clinical variables, and behavioral performance. Results A significant group difference was found for behavioral performance on the WM task, in which the MTBI group had a lower percentage of correct answers than the control group (p < 0.05). The patients with MTBI also had smaller amplitudes of both frontal N350 and parietal P300 ERP components when compared with control volunteers (p < 0.05). No changes were found for latency of ERP components. Smaller ERP amplitudes were associated with slower reaction times and worse accuracy on the WM task among patients with MTBI (p < 0.05). Types of injury (that is, sports concussion vs other mechanisms) were not associated with different ERP characteristics. Conclusions Abnormal ERP results are observed in patients after MTBI or sports concussion, even for those in the nonacute stage after their injury. Current standard clinical evaluations most often fail to detect cerebral dysfunction after MTBI, even when patients or athletes report symptoms. Clinicians should be aware that patients with MTBI, including sports concussion, probably have underlying mild but persistent cerebral dysfunctions that require further investigation.

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“…In particular, Gosselin and associates (2006) reported amplitude reductions of N1, P2, and P3 components following concussions. In other studies, the effects of concussion (or mild brain trauma) were detected only for the late ERP components (P3), mostly affecting amplitude (De Beaumont et al, 2007), but also affecting latency (De Beaumont et al, 2009;Lachapelle et al, 2008). In fact, the effects of concussion on P3 were long-lasting, and could be detected 30 years after the inciting event (De Beaumont et al, 2009).…”

Section: Russo Et Almentioning

confidence: 99%

Benefits of Sports Participation for Executive Function in Disabled Athletes

Russo

Bultrini

Brunelli

et al. 2010

Journal of Neurotrauma

108

103

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We investigated the effect of sports activity on physically-disabled individuals using behavioral and electrophysiological techniques. Visual go/no-go discriminative and simple response tasks were used. Participants included 17 disabled athletes, 9 from open-skill (wheelchair basketball) and eight from closed-skill (swimming) sports, and 18 healthy non-athletes. Reaction times of the disabled athletes were slower than those of healthy non-athletes on both tasks (7% and 13% difference, respectively). Intra-individual variations in reaction times, switch cost, and number of false alarms, were higher in the swimmers, but comparable to healthy non-athletes, in the basketball group. Event-related potentials (ERPs) early components P1, N1, and P2 had longer latencies in the disabled athletes. The late P3 component had longer latency and smaller amplitude in the disabled athletes only in the discriminative response task. The N2 component, which reflected inhibition/execution processing in the discriminative response task, was delayed and reduced in the swimmer group, but was comparable to healthy subjects in the basketball group. Our results show that (1) the ERP components related to perceptual processing, and late components related to executive processing, were impaired in disabled subjects; and (2) open-skill sports such as basketball may partially compensate for executive control impairment by fostering the stability of motor responses and favoring response flexibility.

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Deficits in complex visual information processing after mild TBI: Electrophysiological markers and vocational outcome prognosis

Cited by 56 publications

References 67 publications

Retinal Ganglion Cell Damage in an Experimental Rodent Model of Blast-Mediated Traumatic Brain Injury

Retinal Ganglion Cell Damage in an Experimental Rodent Model of Blast-Mediated Traumatic Brain Injury

Evaluating the cognitive consequences of mild traumatic brain injury and concussion by using electrophysiology

Benefits of Sports Participation for Executive Function in Disabled Athletes

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