Déficits immunitaires primitifs: approche diagnostique pour les pays émergents

Admou, Brahim; Haouach, K.; Ailal, Fatima; Benhsaine, I.; Barbouch, Mohamed Ridha; Béjaoui, Mohamed; Bousfiha, Ahmed Aziz

doi:10.1016/j.immbio.2010.09.003

Cited by 3 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence is underestimated in the world, particularly in Africa [4]. Actually, 2500 patients have been diagnosed in Africa while at least 65,000 patients are expected [5].…”

Section: Discussionmentioning

confidence: 99%

“…In our countries, PID are still poorly understood by physicians, making their diagnosis difficult and delays care. To improve their diagnosis in our country, we organised training sessions for physicians, a few years ago [4]. However, availability of immunological investigations and genetic tests are the main challenge to confirm the diagnosis and manage the treatment.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary Immune Deficiencies (PID): Diagnosis Challenges

Deme-Ly¹,

Kane²,

Gueye³

et al. 2021

OJPed

View full text Add to dashboard Cite

Background: Primary Immune Deficiencies (PID) are rare, under-determined diseases particularly in sub-Saharan Africa. The diagnosis is often suspected with uncommon clinical signs. Infections are the main diagnostic circumstances in infants. Confirmation is often difficult because some additional examinations are unavailable in many of our countries. Aim: Our aim was to share the challenge of diagnosis and treatment in PID. Case Presentation: It is about two infants, a boy and a girl, with early several infections. Both of them presented a hypo-gammaglobulinemia and to the boy, the immuno-phenotyping lymphocyte showed a decreased level of lymphocytes CD19. We are looking for genetic confirmation but it is not easy. The treatment of these infants requires a substitution for life of immunoglobulin which is unavailable in our countries. Conclusion: PID are suspected with atypical clinical signs. Confirmation genetic diagnosis is difficult in low income countries. To improve the follow up, we need to strengthen clinical-biological collaboration.

show abstract

“…The prevalence is underestimated in the world, particularly in Africa [4]. Actually, 2500 patients have been diagnosed in Africa while at least 65,000 patients are expected [5].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary Immune Deficiencies (PID): Diagnosis Challenges

Deme-Ly¹,

Kane²,

Gueye³

et al. 2021

OJPed

View full text Add to dashboard Cite

show abstract

“…The diagnosis was established according to IUIS Primary Immunodeficiency Classification Committee [2]. We have followed the steps proposed by Admou et al for the diagnosis of PID patients [6]. Secondary immunodeficiencies (such as related to drug, HIV infection, or other conditions) were eliminated by doing relative tests.…”

Section: Patient Enrollmentmentioning

confidence: 99%

Comprehensive Report of Primary Immunodeficiency Disorders from a Tertiary Care Center in Marrakesh.

Alaoui

Rada

Admou

et al. 2022

Preprint

View full text Add to dashboard Cite

Introduction Recent advances in immunologic techniques have lead to increase recognition of primary immunodeficiency diseases (PID). Objective We sought to analyze and describe the spectrum of PID at a tertiary care center in Morocco. Methods A retrospective study from 2011 to 2017 was conducted on 27 children diagnosed with PID. Result Over the study period, combined immunodeficiencies with associated or syndromic features were the most common category (48.15%) followed by immunodeficiencies affecting cellular and humoral immunity (25.9%), congenital defects of phagocyte number or function (14.81%), predominantly anti-body deficiencies (7.4%), and diseases of immune dysregulation (3.7%). The most frequent disorder was Ataxia-telangiectasia (44.4%). The mean age at diagnosis was 4.62 years. The consanguinity rate was 74.1%. The principal clinical signs were lower respiratory tract infections (59.2%), neurological manifes-tations (44.4%), failure to thrive (51.8%) and skin infections (33.3%). Two patients who have immunodeficiencies affecting cellular and humoral immunity died. Conclusion This study indicates that PIDs are not rare in Morocco and that combined immunodeficiencies with associated or syndromic features are the most common category. Future research should focus on identifying gene defect for PID patients.

show abstract

“…Primary immunode ciencies diseases have often been considered rare, and several diagnostic tools and approaches have been developed to facilitate diagnosis [1,2,3,4,5]. However, their prevalence is underestimated.…”

Section: Introductionmentioning

confidence: 99%

Primary Immunodeficiencies Diseases (Pid) In Senegalese Children: A Cross Sectional Observational Study

Kane¹,

Deme-Ly²,

Gueye³

et al. 2020

Preprint

View full text Add to dashboard Cite

Objective: Primary immunodeficiencies are rarely related in sub-Saharan Africa. The aim of this study was to identify their different clinical patterns, to describe their biological phenotypes and to analyse treatment. A cross-sectional observational study over a period of 4 years and 2 months in 5 Senegalese paediatric departments was conducted. Children were recruited according to the recommendations of African society for immunodeficiencies (ASID) or the 10 warning signs for PID's diagnosis. Biological explorations were performed in these patients. Results: 30 cases of PID were recorded. The sex ratio was 1:1; with a median age at diagnosis of 24 months. The most common clinical patterns were respiratory infections (18 patients) including tuberculosis pneumonia in almost one-third of cases (22%), followed by digestive and then cutaneous manifestations. This signs occurs in a specific context; as inbreeding (36, 7% of cases), death in sibling (30% of cases), or previous hospitalizations (66, 7%). Biological exploration made it possible to obtain immunological confirmation in 10 children, including one genetically confirmed. The most common category of PID was syndromic PID. Treatment was based mainly on antibiotic prophylaxis. PID are a reality in Senegal, but are certainly underestimated. Continue recruitment will enable advocacy for access to certain treatment.

show abstract

Déficits immunitaires primitifs: approche diagnostique pour les pays émergents

Cited by 3 publications

References 28 publications

Primary Immune Deficiencies (PID): Diagnosis Challenges

Primary Immune Deficiencies (PID): Diagnosis Challenges

Comprehensive Report of Primary Immunodeficiency Disorders from a Tertiary Care Center in Marrakesh.

Primary Immunodeficiencies Diseases (Pid) In Senegalese Children: A Cross Sectional Observational Study

Contact Info

Product

Resources

About