Déficits endocriniens post-traumatiques : analyse d’une sériede 93 traumatismes crâniens graves

Richard, I.; Rome, Jeffrey D.; Lemené, B; Louis, F; Perrouin-Verbe, B.; Mathé, J

doi:10.1016/s0168-6054(00)00059-3

Cited by 10 publications

(2 citation statements)

References 12 publications

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“…Indeed, hypopituitarism itself may be undiagnosed for a long time, sometimes more than 30 years [25]. It is recommended that patients with head trauma be screened for posttraumatic hypopituitarism through regular laboratory testing to confirm diagnosis [22]. In our study, glucagon and lowdose ACTH stimulation tests were performed to assess the ACTH-cortisol axis.…”

Section: Discussionmentioning

confidence: 98%

“…In a retrospective study of 93 severe traumatic brain injuries, isolated hypotestosteronemia (all of which are of central origin) was found to be the most common hormone deficit, even though GH status was not assessed [22]. In a study of 15 patients with severe head trauma, the most common associated deficiencies were in gonadotropins (60%) and GH (58%) [3].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of pituitary function and metabolic parameters in patients with traumatic maxillofacial fractures

Daloglu,

Unal,

Kemaloglu

et al. 2024

J Endocrinol Invest

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Purpose This study was designed to assess the pituitary functions of patients with traumatic maxillofacial fractures and compare the results with healthy controls. Methods Thirty patients (mean age, 38.14 ± 14.15 years; twenty-six male, four female) with a traumatic maxillofacial fracture at least 12 months ago (mean 27.5 ± 6.5 months) and thirty healthy controls (mean age, 42.77 ± 11.36 years; twenty-five male, five female) were included. None of the patients were unconscious following head trauma, and none required hospitalization in intensive care. Basal pituitary hormone levels of the patients were evaluated. All patients and controls had a glucagon stimulation test and an ACTH stimulation test to evaluate the hypothalamic–pituitary–adrenal axis and the GH–IGF-1 axis. Results Five of thirty patients (16.6%) had isolated growth hormone (GH) deficiency based on a glucagon stimulation test (GST). The mean peak GH level after GST in patients with hypopituitarism (0.54 ng/ml) was significantly lower than those without hypopituitarism (7.01 ng/ml) and healthy controls (11.70 ng/ml) (P < 0.001). No anterior pituitary hormone deficiency was found in the patients, except for GH. Conclusion Our study is the first to evaluate the presence of hypopituitarism in patients with traumatic maxillofacial fractures. Preliminary findings suggest that hypopituitarism and GH deficiency pose significant risks to these patients, particularly during the chronic phase of their trauma. However, these findings need to be validated in larger scale prospective studies with more patients.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Evaluation of pituitary function and metabolic parameters in patients with traumatic maxillofacial fractures

Daloglu,

Unal,

Kemaloglu

et al. 2024

J Endocrinol Invest

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Endocrine dysfunction following traumatic brain injury: mechanisms, pathophysiology and clinical correlations

Samadani

Reyes-Moreno

Buchfelder

2005

Re-Engineering of the Damaged Brain and Spinal Cord

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Boxing as a sport activity associated with isolated GH deficiency

Keleştimur

Tanrıverdi

Atmaca

et al. 2004

J Endocrinol Invest

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Traumatic brain injury (TBI) has long been known as a cause of hypopituitarism, and it is characterized by a high prevalence of neuroendocrine abnormalities. Boxing, one of the most common combative sports, may also result in TBI. As far as we know, pituitary functions including GH status have not been investigated in boxers. Therefore, in this preliminary study, we have assessed the pituitary functions in boxers. Eleven actively competing or retired male boxers with a mean age of 38.0 +/- 3.6 yr and 7 age-, sex- and BMI-matched healthy non-boxing controls were included in the study. Biochemical and basal hormonal parameters including IGF-I levels were measured. To assess GH secretory status in boxers and healthy controls, GHRH (1 microg/kg)+GHRP-6 (1 microg/kg) test was performed. After GHRH+GHRP-6 test, mean peak GH level in boxers and in controls were 10.9 +/- 1.7 and 41.4 +/- 6.7 microg/l, respectively (p < 0.05). Peak GH levels in 5 (45%) boxers were found to be lower than 10 microg/l and considered as severe GH deficient. In the control group, mean IGF-1 levels (367 +/- 18.8 ng/ml) were significantly higher than that obtained in boxers (237 +/- 23.3 ng/dl) (p < 0.01). All the other pituitary hormones were normal including ADH as no signs and symptoms of diabetes insipidus. There was a significant negative correlation between peak GH levels and boxing duration, and between peak GH levels and number of bouts. In conclusion, we think that boxing is a cause of TBI, and GH deficiency is very common among boxers. Further studies including large number of boxers, both professional and amateur, are needed to clarify pituitary dysfunction in boxers.

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Déficits endocriniens post-traumatiques : analyse d’une sériede 93 traumatismes crâniens graves

Cited by 10 publications

References 12 publications

Evaluation of pituitary function and metabolic parameters in patients with traumatic maxillofacial fractures

Evaluation of pituitary function and metabolic parameters in patients with traumatic maxillofacial fractures

Endocrine dysfunction following traumatic brain injury: mechanisms, pathophysiology and clinical correlations

Boxing as a sport activity associated with isolated GH deficiency

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