Deficit syndrome in older schizophrenic patients

Harris, M. Jackuelyn; Jeste, Dilip V.; Krull, Alice J.; Montague, John; Heaton, Robert K.

doi:10.1016/0165-1781(91)90094-6

Cited by 30 publications

(20 citation statements)

References 25 publications

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“…Although this expectation is supported by several studies (Harris et al 1991;Hori et al 1999;Kendler et al 1985;Murphy et al 1994) others failed to show this association (Kay et al 1989;Montague et al 1989;Ring et al 1991). Apart from many other methodological differences between the various studies, two major reasons for these contradictory findings may be seen in differences in the length of illness of the assessed patients and in differences in the concept of negative symptoms, whereby most studies deal with a wide concept of negative symptoms and do not differentiate between primary and secondary negative symptoms.…”

Section: Introductionmentioning

confidence: 42%

Deficit states in schizophrenia and their association with the length of illness and gender

Bottlender¹,

Jäger²,

Groll³

et al. 2001

European Archives of Psychiatry and Clinical Neurosciences

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The present study investigated the association between the frequency of deficit states (DS) and the length of illness and gender in schizophrenic patients. The following hypotheses were examined: 1) there is an association between the length of schizophrenic illness and the frequency of DS and 2) the frequency of DS in patients with comparable length of illness is higher in males than in females. Patients, included in the study, were consecutively hospitalized and diagnosed according to ICD-9 criteria (ICD-9: 295-295.9). Psychopathological assessment was performed in a standardized manner. Group differences were evaluated by using the t-test or the chi-square statistics. Variables with a possible impact on the occurrence of DS were entered into a backward multiple logistic regression model. 622 patients (total = 3914) were classified as having a DS. Logistic regression analysis revealed that the risk of having a DS was increased with a longer duration of illness (OR =1.68) and was reduced for female gender (OR = 0.56). The findings are in line with the hypothesis that apart from a neurodevelopmental origin, the schizophrenic illness may also have a progressive neurodegenerative component, which clinically emerges as DS.

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Section: Introductionmentioning

confidence: 42%

Deficit states in schizophrenia and their association with the length of illness and gender

Bottlender¹,

Jäger²,

Groll³

et al. 2001

European Archives of Psychiatry and Clinical Neurosciences

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“…Additionally, there is some evidence to suggest that negative symptoms become more prominent with increasing age and illness chronicity. 30,59,60 Due to the relatively low presentation of negative symptoms in the present study, it is possible that this variable was not sufficiently sensitive to be predictive of psychological well-being.…”

Section: Discussionmentioning

confidence: 80%

Psychological well‐being among individuals with first‐episode psychosis

Uzenoff¹,

Brewer²,

Perkins

et al. 2010

Early Intervention Psych

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These results suggest that the development of a psychotic episode is associated with decreased subjective well-being, and that depression and social support may play an important role in this aspect of an individual's recovery. Additionally, the SPWB appear to be tapping into an important construct that has been relatively unexamined in first-episode research and may have potential utility in clinical practice and future treatment development.

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“…In previous studies (Owens and Johnstone, 1980;Johnstone et al, 1985;Mathai and Gopinath, 1985;Wagman et al, 1987;Carpenter et al, 1988;Harris et al, 1992), the incidence of deficit symptoms has varied considerably depending on the nature of the sample and the methods of assessment. Our samples of elderly and younger schizophrenic patients showed a high frequency and severity of negative and disorganization symptoms.…”

Section: Discussionmentioning

confidence: 99%

The elderly chronic schizophrenic inpatient: A study of psychiatric morbidity in ‘elderly graduates’

Soni

Mallik

1993

Int J Geriat Psychiatry

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SUMMARYThis study surveyed all chronic schizophrenic patients from I 1 long-stay wards of a mental hospital. Patients were assessed on a variety of rating scales to assess clinical psychopathology and behaviour. Patients above the age of 65 years were studied in detail and also compared with those under that age living on the same wards. It was found that all the elderly schizophrenic patients in the sample had severe deficits in the form of residual negative symptoms and thought disorder. They had significantly fewer positive but more negative symptoms as compared to a younger sample on the same wards; there was no differences between the groups for affective symptoms or thought disorder. Although there were more males in the sample, no difference was found on any of the parameters between the two sexes. It was concluded that there are significant clinical differences in the 'elderly graduates' as compared to younger patients living in an identical environment; such findings could assist managers and administrators in the development of plans for other patients in this age group who are likely to be relocated from psychiatric hospitals in the near future or are already living in the community.

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Deficit syndrome in older schizophrenic patients

Cited by 30 publications

References 25 publications

Deficit states in schizophrenia and their association with the length of illness and gender

Deficit states in schizophrenia and their association with the length of illness and gender

Psychological well‐being among individuals with first‐episode psychosis

The elderly chronic schizophrenic inpatient: A study of psychiatric morbidity in ‘elderly graduates’

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