Déficit parcial de ACTH asociado a esclerosis múltiple

Matías‐Guiu, Jordi A.; Ramos-Leví, Ana M.; Sanabria-Pérez, Concepción

doi:10.1016/j.endonu.2010.11.004

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Among the effects of ACTH-like peptide on the target cells there were detected an increase in adenylate cyclase activity, and intracellular cAMP content. At the same time, there is a report that treatment with exogenous ACTH aggravated symptoms in MS patients with deficiency of endogenous ACTH (Matias-Guiu et al, 2011 ).…”

Section: Discussionmentioning

confidence: 97%

Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis

et al. 2018

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Peptide immunocortin sequence corresponds to the amino acid residues 11–20 of the variable part of human immunoglobulin G1 (IgG1) heavy chain. Since immunocortin was shown previously to inhibit phagocytosis in peritoneal macrophages and ConA-induced T-lymphocytes proliferation in culture, we suggested that immunocortin administering may be of use for patients with self-immune syndrome. Immunocortin in concentration 10 μM inhibited proliferation of both antigen (myelin)-induced and ConA-induced LN lymphocytes isolated from the lymph nodes of Dark Agouti (DA) rats immunized with chorda shear. The biological trials of the synthetic immunocortin were carried out on the DA rats with induced experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. These in vivo experiments have shown that intraperitoneal injections of immunocortin in a daily dosage 100 μg per animal reduced symptoms of EAE in DA rats.

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Section: Discussionmentioning

confidence: 97%

Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis

et al. 2018

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“…En un informe de caso de un paciente con EM, por ejemplo, se vio que había una insuficiencia parcial de la función de la hormona adrenocorticotropa [18]. A pesar de ser un informe clínico, lo que más resaltó fue que la deficiencia de la función de la hormona adrenocorticotropa se relacionaba con la disfunción del eje HHA [18].…”

Section: Eje Hha Y Esclerosis Múltipleunclassified

“…Cuando estamos en secreción constante y crónica de hormonas estresoras, tendemos a producir depresión y fatiga. En este caso, debido a la no regulación de las vías glutamatérgicas causadas por la destrucción de células inflamatorias y el daño estructural del eje HHA, tenemos una exposición crónica a corticoides que lleva finalmente a un estado crónico de fatiga [18].…”

Section: Tema Principales Hallazgosunclassified

Importancia del glutamato en las funciones neuroendocrinológicas en la esclerosis múltiple relacionadas con la fatiga

Pedraz

Sammer²

2018

RevNeurol

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The importance of glutamate in the neuro-endocrinological functions in multiple sclerosis, related to fatigue Summary. Multiple sclerosis is an inflammatory disease, which still today affects the Northern-hemisphere population, generating a socioeconomically burden. One of the most unfavorable symptoms in this chronic disorder is fatigue. In this review, we favor and sustain a main alteration of the hypothalamus-pituitary-axis complex and its physiopathologic consequences, mostly related to glutamate and corticoid levels. We try to sustain our hypothesis in what is already reported, corroborating that the inflammatory cells release mainly glutamate, a neuro-toxic substance which leads to a demyelinating effect and as a main result fatigue as a symptom. When this hypothesis is demonstrated, we could trace therapeutic targets to stop the release of glutamate of these immunologic cells, in order to avoid fatigue in multiple sclerosis patients.

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Consideration regarding immune checkpoint inhibitor–induced secondary adrenal insufficiency in patients lacking human leucocyte antigen-DR15

Kanzaki

Otsuki

Arii

et al. 2021

European Journal of Cancer

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Déficit parcial de ACTH asociado a esclerosis múltiple

Cited by 3 publications

References 9 publications

Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis

Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis

Importancia del glutamato en las funciones neuroendocrinológicas en la esclerosis múltiple relacionadas con la fatiga

Consideration regarding immune checkpoint inhibitor–induced secondary adrenal insufficiency in patients lacking human leucocyte antigen-DR15

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