Deficit of sensorimotor integration in normal aging

Degardin, Adrian; Devos, David; Cassim, F.; Bourriez, Jean‐Louis; Defebvre, Luc; Derambure, Philippe; Devanne, H.

doi:10.1016/j.neulet.2011.05.010

Cited by 49 publications

(45 citation statements)

References 32 publications

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“…This lack of relationship was present despite clear reductions in SAI with age, which is consistent with our previous results in an independent sample (Young-Bernier et al, 2012; but see Oliviero et al, 2006; Degardin et al, 2011) and other evidence of a deterioration of the cholinergic system in normal aging (e.g., Mesulam et al, 2004; Duzel et al, 2010; Dumas and Newhouse, 2011; Grothe et al, 2012). …”

Section: Discussionsupporting

confidence: 92%

“…SAI levels are significantly reduced by scopolamine, a muscarinic cholinergic antagonist, in young healthy adults (Di Lazzaro et al, 2000) and can be improved with acetylcholinesterase inhibitors in patients with AD (Di Lazzaro et al, 2002). Using a constant TMS test intensity protocol, we have previously shown that SAI is also reduced in normal aging (Young-Bernier et al, 2012; but see Oliviero et al, 2006; Degardin et al, 2011). …”

Section: Introductionmentioning

confidence: 98%

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Short-latency afferent inhibition is a poor predictor of individual susceptibility to rTMS-induced plasticity in the motor cortex of young and older adults

Young-Bernier

Tanguay

Davidson

et al. 2014

Front. Aging Neurosci.

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Cortical plasticity, including long-term potentiation (LTP)-like plasticity, can be assessed non-invasively with repetitive transcranial magnetic stimulation (rTMS) protocols. In this study, we examined age differences in responses to intermittent theta burst stimulation (iTBS) in a group of 20 young and 18 healthy older adults. Because the cholinergic system plays a role in the neural processes underlying learning and memory, including LTP, we also investigated whether short latency afferent inhibition (SAI), a neurophysiological marker of central cholinergic activity, would be associated with age-related differences in LTP-like plasticity induced by iTBS.Methods: SAI was first assessed by examining the modulation of motor evoked potentials (MEPs) in response to median nerve conditioning 20 ms prior to TMS. Participants then underwent iTBS (3 pulses at 50 Hz every 200 ms for 2 s with 8 s between trains, repeated 20 times). MEP responses (120% resting motor threshold (RMT)) were assessed immediately after iTBS and 5, 10, and 20 min post-application.Results: Responses to iTBS were quite variable in both age groups, with only approximately 60% of the participants (n = 13 young and 10 older adults) showing the expected facilitation of MEP responses. There were no significant age group differences in MEP facilitation following iTBS. Although older adults exhibited reduced SAI, individual variations were not associated with susceptibility to express LTP-like induced plasticity after iTBS.Conclusion: Overall, these results are consistent with reports of high inter-individual variability in responses to iTBS. Although SAI was reduced in older adults, consistent with a deterioration of the cholinergic system with age, SAI levels were not associated with LTP-like plasticity as assessed with iTBS.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 98%

Short-latency afferent inhibition is a poor predictor of individual susceptibility to rTMS-induced plasticity in the motor cortex of young and older adults

Young-Bernier

Tanguay

Davidson

et al. 2014

Front. Aging Neurosci.

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“…Refer to Fig. 2 for the Hedge’s g forest plot for RMT comparing older versus young adults (Rossini et al , 1992, Matsunaga et al , 1998, Kossev et al , 2002, Sale et al , 2005, Hortobagyi et al , 2006, Muller-Dahlhaus et al , 2008, Tecchio et al , 2008, Fujiyama et al , 2009, Pellicciari et al , 2009, Rogasch et al , 2009, Smith et al , 2009, Cirillo et al , 2010, Fathi et al , 2010, Cirillo et al , 2011, Clark et al , 2011, Degardin et al , 2011, Fujiyama et al , 2011, Levin et al , 2011, Saisanen et al , 2011, Smith et al , 2011a, Smith et al , 2011b, Bernard et al , 2012, Fujiyama et al , 2012a, Fujiyama et al , 2012b, Young-Bernier et al , 2012a, Cuypers et al , 2013, Hinder et al , 2013, Opie et al , 2014, Young-Bernier et al , 2014). …”

Section: Resultsmentioning

confidence: 99%

A meta-analysis of the effects of aging on motor cortex neurophysiology assessed by transcranial magnetic stimulation

Bhandari

Radhu

Farzan

et al. 2016

Clinical Neurophysiology

125

104

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Objective Transcranial magnetic stimulation (TMS) is a non-invasive tool used for studying cortical excitability and plasticity in the human brain. This review aims to quantitatively synthesize the literature on age-related differences in cortical excitability and plasticity, examined by TMS. Methods A literature search was conducted using MEDLINE, Embase, and PsycINFO from 1980 to December 2015. We extracted studies with healthy old (50–89 years) versus young (16–49 years) individuals that utilized the following TMS measures: resting motor threshold (RMT), short-interval cortical inhibition (SICI), short-latency afferent inhibition (SAI), cortical silent period (CSP), intracortical facilitation (ICF), and paired associative stimulation (PAS). Results We found a significant increase in RMT (g = 0.414, 95% confidence interval (CI) [0.284, 0.544], p<0.001), a significant decrease in SAI (g=0.778, 95% CI [0.478, 1.078], p<0.001), and a trending decrease in LTP-like plasticity (g=−0.528, 95% CI [−1.157, 0.100 p<0.1) with age. Conclusions Our findings suggest an age-dependent reduction in cortical excitability and sensorimotor integration within the human motor cortex. Significance Alterations in the ability to regulate cortical excitability, sensorimotor integration and plasticity may underlie several age-related motor deficits.

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“…Normal aging has been repeatedly associated with a decline in sensorimotor functions (Bugnariu and Fung 2007;Berard et al 2009;Degardin et al 2011). Age-related deficits in motor coordination are notably illustrated by evidence that the elderly exhibit temporal impairments even in basic sensorimotor tasks consisting of synchronized tapping with two hands at an isofrequency rate (Swinnen et al 1998;Serrien et al 2000;Wishart et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Age-related changes in the bimanual advantage and in brain oscillatory activity during tapping movements suggest a decline in processing sensory reafference

et al. 2013

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UM tapping in the young, but not in the elderly group. This result indicates that in self-paced tapping, the bimanual advantage is absent in elderly. Electrophysiological results revealed an interaction between tapping condition and age group on low beta band (14-20 Hz) activity. Beta activity varied depending on the tapping condition in the elderly but not in the young group. Source estimations localized this effect within left superior parietal and left occipital areas. We interpret our results in terms of engagement of different mechanisms in the elderly depending on the tapping mode: a 'kinesthetic' mechanism for UM and a 'visual imagery' mechanism for BM tapping movement.

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Deficit of sensorimotor integration in normal aging

Cited by 49 publications

References 32 publications

Short-latency afferent inhibition is a poor predictor of individual susceptibility to rTMS-induced plasticity in the motor cortex of young and older adults

Short-latency afferent inhibition is a poor predictor of individual susceptibility to rTMS-induced plasticity in the motor cortex of young and older adults

A meta-analysis of the effects of aging on motor cortex neurophysiology assessed by transcranial magnetic stimulation

Age-related changes in the bimanual advantage and in brain oscillatory activity during tapping movements suggest a decline in processing sensory reafference

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