Déficit non amyloïde acquis en facteur X : un premier cas satellite d’une leucémie lymphoïde chronique atypique et revue de la littérature

Boudin, L.; Patient, M.; Romeo, E.; Blade, J.-S.; Gisserot, O.; Jauréguiberry, J.P. de

doi:10.1016/j.revmed.2016.12.003

La Revue de Médecine Interne

2017

DOI: 10.1016/j.revmed.2016.12.003

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Déficit non amyloïde acquis en facteur X : un premier cas satellite d’une leucémie lymphoïde chronique atypique et revue de la littérature

L. Boudin

M. Patient

E. Romeo

et al.

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2022

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Cited by 2 publications

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Isolated coagulopathy without classic CRAB symptoms as the initial manifestation of multiple myeloma: A case report

Zhang¹,

Fang²,

Wen³

et al. 2022

WJCC

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BACKGROUND Multiple myeloma patients usually present with CRAB symptoms (hypercalcemia, renal disease, anemia and bone diseases) as initial manifestations. Bleeding symptoms are less common, most of which result from thrombocytopenia or infiltration of plasmacytoma. Relatively, coagulopathy is not so common, especially isolated coagulopathy without CRAB manifestations, which is very rare. Herein, we report a 54-year old female who was hospitalized for intermittent and recurrent mild oral mucosal hemorrhage without other bleeding symptoms for almost one month or typical myeloma features. CASE SUMMARY Two months before admission, the patient underwent implantation of a permanent pacemaker due to sick sinus syndrome. Prothrombin time and activated partial thromboplastin time were significantly prolonged. Factor X deficiency was demonstrated to account for the coagulation dysfunction. An M protein peak was shown by serum protein electrophoresis. 26.11% of abnormal plasma cells were detected in bone marrow by flow cytometry, expressing CD38, CD138, CD56 and intracellular immunoglobulin Kappa light chain. Bone marrow biopsy also proved the presence of abnormal plasma cells, but Congo red stain was negative. The patient was finally diagnosed with multiple myeloma IgA-κ type. A literature review indicated that factor X deficiency was highly related to amyloidosis. Before bleeding signs, the patient had cardiac arrhythmia, enlargement of the heart, and progressive heart failure; thus, cardiac amyloidosis was suspected. CONCLUSION Bleeding related to coagulation dysfunction is uncommon in multiple myeloma, especially as the initial manifestation. Amyloidosis is a well-recognized cause of isolated acquired factor X deficiency.

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Isolated coagulopathy without classic CRAB symptoms as the initial manifestation of multiple myeloma: A case report

Zhang¹,

Fang²,

Wen³

et al. 2022

WJCC

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Chronic Lymphocytic Leukemia of <i>del</i> 17p in a Young Subject: About a Case and Reviewed a Literature

Djibrilla-Almoustapha¹,

Mamane-Brah²,

Elhadj-Chefou³

et al. 2022

OJBD

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Objective: To report a case of Chronic Lymphoid Leukemia in a 28-year-old young subject, with variable clinical features and a TP53 mutation, diagnosed and followed up in the Onco-Hematology department of the HNN. Observation: 28-year-old patient, having consulted for polyadenopathy and physical asthenia, whose clinical examination found a conscious patient, submaxillary, laterocervical, axillary and inguinal lymphadenopathy, bilateral, symmetrical, painless and non-compressive whose largest measures 3 cm in diameter. Hepato-splenomegaly and epistaxis. Predominantly lymphocyte hyperleukocytosis, immunophenotyping revealed low CD19+, CD5+, CD23+, CD20 monoclonal B lymphoid proliferation. The Matutes score was 4. A karyotype showed a three-chromosome translocation; the short arm of a chromosome 2, the long arm of a chromosome 11 and the long arm of a chromosome 13, and a translocation between the long arm of a chromosome 6 and the long arm of a chromosome 18. A FISH objectified a led 17p. The diagnosis of Binet Stage C CLL with positive del 17p and complex karyotype was retained. Despite the poor prognosis, the R-C (Rituximab-Chlorambucil) protocol was instituted with once-weekly transfusions. The patient is still alive in partial clinical and biological remission. Conclusion: Despite therapeutic progress, the presence of the deletion of chromosome 17p with TP53 mutation and the young age of the patient does not change the patient's prognosis.

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Déficit non amyloïde acquis en facteur X : un premier cas satellite d’une leucémie lymphoïde chronique atypique et revue de la littérature

Cited by 2 publications

References 21 publications

Isolated coagulopathy without classic CRAB symptoms as the initial manifestation of multiple myeloma: A case report

Isolated coagulopathy without classic CRAB symptoms as the initial manifestation of multiple myeloma: A case report

Chronic Lymphocytic Leukemia of <i>del</i> 17p in a Young Subject: About a Case and Reviewed a Literature

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Déficit non amyloïde acquis en facteur X : un premier cas satellite d’une leucémie lymphoïde chronique atypique et revue de la littérature

Cited by 2 publications

References 21 publications

Isolated coagulopathy without classic CRAB symptoms as the initial manifestation of multiple myeloma: A case report

Isolated coagulopathy without classic CRAB symptoms as the initial manifestation of multiple myeloma: A case report

Chronic Lymphocytic Leukemia of &lt;i&gt;del&lt;/i&gt; 17p in a Young Subject: About a Case and Reviewed a Literature

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Chronic Lymphocytic Leukemia of <i>del</i> 17p in a Young Subject: About a Case and Reviewed a Literature