Déficit de la vitamina D e hipertensión arterial. Evidencias a favor

Torres, Yaniel Castro; Pérez, Alicia García; Puerta, Raimundo Carmona; Valdez, Marlen Vega; Castillo, Indira Santiestebán

doi:10.1016/j.rccar.2015.06.005

“…Con respecto a las comorbilidades, destacamos a la población de pacientes con hipertensión arterial quienes presentaron niveles inferiores a 20 ng/ml de vitamina D. En varios estudios se ha observado una asociación inversa entre los niveles de vitamina D y presión arterial 21 , entre los mecanismos sugeridos está que la vitamina D inhibe el sistema renina angiotensina aldosterona, favorece la protección de los vasos sanguíneos, contribuye a la homeostasis del calcio, disminuye el estrés oxidativo y favorece la síntesis de prostaglandinas 5 . Recientemente se reportó que las personas presentan el polimorfismo FokI en el gen que codifica para el receptor de la vitamina D tienen un riesgo incrementado de desarrollar hipertensión arterial 22 .…”

Section: Discusionunclassified

“…Las diferencias entre los valores de 25-hidroxicolecalciferol y las cifras de la Presión arterial fue mayor en los participantes ≥ 50 años de edad, en comparación con los jóvenes (p=0,021). Estos resultados apoyan la hipótesis que plantea una relación entre la capacidad de producción y/o absorción de la vitamina D en las personas de la tercera edad y el riesgo de presentar HTA 21,25 .…”

Section: Discusionunclassified

Niveles de Vitamina D en pacientes con y sin Enfermedad Renal Crónica, perfil clínico y epidemiológico: un análisis preeliminiar en un hospital de segundo nivel en quito, Ecuador.

Benítez-Baldassari,

León-Hernández,

Banegas-Sarmiento

et al. 2024

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Vitamin D has been associated with different effects unrelated to bone-mineral metabolism, such as its association with arterial hypertension. This study determines the prevalence profile of vitamin D deficiency and insufficiency in Ecuadorian patients, its epidemiological profile, and its relationship with other diseases such as arterial hypertension, diabetes mellitus, and chronic kidney disease. This is a pioneering study in Ecuador of a retrospective type, carried out at the Pablo Arturo Suarez Hospital over 6 months, in which it was found that the prevalence of vitamin D insufficiency was 28.5% (levels between 21 to 30 ng/ml) and deficiency was 57% (levels less than 20 ng/ml); Likewise, we ratify the inverse relationship between vitamin D levels and age, as well as finding a certain association between vitamin D levels and the presence of arterial hypertension; while no significant differences were found in its relationship with diabetes mellitus, chronic kidney disease without the use of renal replacement therapy and the general population. Keywords: vitamin D, chronic kidney disease, metabolism.

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Niveles de Vitamina D en pacientes con y sin Enfermedad Renal Crónica, perfil clínico y epidemiológico: un análisis preeliminiar en un hospital de segundo nivel en Quito, Ecuador.

Benítez-Baldassari,

León-Hernández,

Banegas-Sarmiento

et al. 2024

RB

0

View full text Add to dashboard Cite

Vitamin D has been associated with different effects unrelated to bone-mineral metabolism, such as its association with arterial hypertension. This study determines the prevalence profile of vitamin D deficiency and insufficiency in Ecuadorian patients, its epidemiological profile, and its relationship with other diseases such as arterial hypertension, diabetes mellitus, and chronic kidney disease. This is a pioneering study in Ecuador of a retrospective type, carried out at the Pablo Arturo Suarez Hospital over 6 months, in which it was found that the prevalence of vitamin D insufficiency was 28.5% (levels between 21 to 30 ng/ml) and deficiency was 57% (levels less than 20 ng/ml); Likewise, we ratify the inverse relationship between vitamin D levels and age, as well as finding a certain association between vitamin D levels and the presence of arterial hypertension; while no significant differences were found in its relationship with diabetes mellitus, chronic kidney disease without the use of renal replacement therapy and the general population. Keywords: vitamin D, chronic kidney disease, metabolism.

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Vitamin D and hypertension

Jandrić-Kočić¹

2023

Med gl Spec bol štit Zlatibor

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Vitamin D is the name for a group of fatsoluble secosteroids, prohormones. Almost all tissues of the human body have vitamin D receptors. 3% of the human genome is under the influence of vitamin D. A significant number of epidemiological studies confirmed the integral connection of vitamin D and its metabolites with the value of blood pressure. Vitamin D lowers blood pressure by inhibiting the renin-angiotensin-aldosterone system, modulating the tone of vascular smooth muscle cells and influencing the vascular endothelium. The results of randomized controlled trials and meta-analyses of the same do not generally support the widespread use of vitamin D in the prevention and treatment of arterial hypertension. Nevertheless, a large number of experimental studies confirm the antihypertensive effect of vitamin D supplementation predominantly in people aged ≥ 50 years as well as obese people with vitamin D deficiency. Further research is needed to determine the potential benefit of vitamin D replacement therapy in hypertensive people.

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Déficit de la vitamina D e hipertensión arterial. Evidencias a favor

Cited by 3 publications

References 49 publications

Niveles de Vitamina D en pacientes con y sin Enfermedad Renal Crónica, perfil clínico y epidemiológico: un análisis preeliminiar en un hospital de segundo nivel en quito, Ecuador.

Niveles de Vitamina D en pacientes con y sin Enfermedad Renal Crónica, perfil clínico y epidemiológico: un análisis preeliminiar en un hospital de segundo nivel en quito, Ecuador.

Niveles de Vitamina D en pacientes con y sin Enfermedad Renal Crónica, perfil clínico y epidemiológico: un análisis preeliminiar en un hospital de segundo nivel en Quito, Ecuador.

Vitamin D and hypertension

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