Deficient multisensory integration in schizophrenia: An event-related potential study

Stekelenburg, Jeroen J.; Maes, Jan Pieter; Gool, Arthur R. Van; Sitskoorn, Margriet M.; Vroomen, Jean

doi:10.1016/j.schres.2013.04.038

Cited by 63 publications

(53 citation statements)

References 41 publications

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“…The present findings also correspond with evidence from an ERP study on audiovisual speech processing in SZP and HC (Stekelenburg et al 2013). This study found no group differences in P2 amplitudes in response to congruent and incongruent audiovisual speech stimuli.…”

Section: Discussionsupporting

confidence: 90%

“…auditory signal was not systematically varied. Similar to the present GFP effect, Stekelenburg et al (2013) found no differences in ERPs to congruent and incongruent audiovisual speech around 200 ms after auditory onset between HC and SZP. Hence, the present finding indicates an intact detection of audiovisual stimulus incongruence in the auditory cortex of SZP.…”

Section: Discussionsupporting

confidence: 87%

“…One behavioral study in SZP revealed a diminished benefit of viewing lip movements for the recognition of auditory speech that is presented at an intermediate noise level (Ross et al 2007). Moreover, an electroencephalography (EEG) study suggested altered audiovisual processing, as reflected in event-related potentials (ERPs), using nonspeech stimuli (Stekelenburg et al 2013). Together, this suggests a multisensory integration deficit in SZP (Ross et al 2007;Stekelenburg et al 2013; but see Martin et al 2013).…”

Section: New and Noteworthymentioning

confidence: 99%

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Reduced frontal theta oscillations indicate altered crossmodal prediction error processing in schizophrenia

Romero

Keil

Balz

et al. 2016

Journal of Neurophysiology

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Our brain generates predictions about forthcoming stimuli and compares predicted with incoming input. Failures in predicting events might contribute to hallucinations and delusions in schizophrenia (SZ). When a stimulus violates prediction, neural activity that reflects prediction error (PE) processing is found. While PE processing deficits have been reported in unisensory paradigms, it is unknown whether SZ patients (SZP) show altered crossmodal PE processing. We measured high-density electroencephalography and applied source estimation approaches to investigate crossmodal PE processing generated by audiovisual speech. In SZP and healthy control participants (HC), we used an established paradigm in which high- and low-predictive visual syllables were paired with congruent or incongruent auditory syllables. We examined crossmodal PE processing in SZP and HC by comparing differences in event-related potentials and neural oscillations between incongruent and congruent high- and low-predictive audiovisual syllables. In both groups event-related potentials between 206 and 250 ms were larger in high- compared with low-predictive syllables, suggesting intact audiovisual incongruence detection in the auditory cortex of SZP. The analysis of oscillatory responses revealed theta-band (4-7 Hz) power enhancement in high- compared with low-predictive syllables between 230 and 370 ms in the frontal cortex of HC but not SZP. Thus aberrant frontal theta-band oscillations reflect crossmodal PE processing deficits in SZ. The present study suggests a top-down multisensory processing deficit and highlights the role of dysfunctional frontal oscillations for the SZ psychopathology.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

Section: New and Noteworthymentioning

confidence: 99%

See 1 more Smart Citation

Reduced frontal theta oscillations indicate altered crossmodal prediction error processing in schizophrenia

Romero

Keil

Balz

et al. 2016

Journal of Neurophysiology

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“…While analyses of task performance and fMRI data have shown abnormalities of audiovisual integration in schizophrenia [16,45], on the whole, neurophysiological studies of audiovisual integration in psychiatric patients are very few. As far as we know, only 1 EEG study has reported deficits of multisensory interaction for N100 in schizophrenia, and even so, the laterality of N100 deficits was unclear [46]. Furthermore, while the importance of P50 as an index of sensory gating has been established [14], no studies have reported multisensory integration effects of P50 for any psychiatric disorders.…”

Section: Discussionmentioning

confidence: 99%

Early Integration Processing between Faces and Vowel Sounds in Human Brain: An MEG Investigation

et al. 2015

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Objective: Unconscious fast integration of face and voice information is a crucial brain function necessary for communicating effectively with others. Here, we investigated for evidence of rapid face-voice integration in the auditory cortex. Methods: Magnetic fields (P50m and N100m) evoked by visual stimuli (V), auditory stimuli (A) and audiovisual stimuli (VA), i.e. by face, vowel and simultaneous vowel-face stimuli, were recorded in 22 healthy subjects. Magnetoencephalographic data from 28 channels around bilateral auditory cortices were analyzed. Results: In both hemispheres, AV - V showed significantly larger P50m amplitudes than A. Additionally, compared with A, the N100m amplitudes and dipole moments of AV - V were significantly smaller in the left hemisphere, but not in the right hemisphere. Conclusions: Differential changes in P50m (bilateral) and N100m (left hemisphere) that occur when V (faces) are associated with A (vowel sounds) indicate that AV (face-voice) integration occurs in early processing, likely enabling us to communicate effectively in our lives.

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“…Research has investigated crossmodal interactions across typical development and ageing (Hillock-Dunn and Wallace, 2012;Poliakoff et al, 2006), and in neurodevelopmental disorders such as dyslexia (Facoetti et al, 2010;Harrar et al, 2014), autism spectrum condition (Foss-Feig et al, 2010), schizophrenia (Stekelenburg et al, 2013), and developmental dyspraxia (Bair et al, 2012). Few researchers investigating crossmodal processing, however, have attempted to constrain unisensory performance, that is, equating performance between par ticipants in a single sensory modality before measuring the effect of adding an additional modality.…”

Section: Introductionmentioning

confidence: 99%

Adapting the Crossmodal Congruency Task for Measuring the Limits of Visual–Tactile Interactions Within and Between Groups

Poole

Couth²,

Gowen³

et al. 2015

Multisens Res

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The crossmodal congruency task (CCT) is a commonly used paradigm for measuring visual-tactile interactions and how these may be influenced by discrepancies in space and time between the tactile target and visual distractors. The majority of studies which have used this paradigm have neither mea sured, nor attempted to control, individual variability in unisensory (tactile) performance. We have developed a version of the CCT in which unisensory baseline performance is constrained to enable comparisons within and between participant groups. Participants were instructed to discriminate be tween single and double tactile pulses presented to their dominant hand, at their own approximate threshold level. In Experiment 1, visual distractors were presented at -30 ms, 100 ms, 200 ms and 400 ms stimulus onset asynchronies. In Experiment 2, ipsilateral visual distractors were presented 0 cm, 21 cm, and 42 cm vertically from the target hand, and 42 cm in a symmetrical, contralat eral position. Distractors presented -30 ms and 0 cm from the target produced a significantly larger congruency effect than at other time points and spatial locations. Thus, the typical limits of visualtactile interactions were replicated using a version of the task in which baseline performance can be constrained. The usefulness of this approach is supported by the observation that tactile thresh olds correlated with self-reported autistic traits in this non-clinical sample. We discuss the suitability of this adapted version of the CCT for measuring visual-tactile interactions in populations where unisensory tactile ability may differ within and between groups.

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Deficient multisensory integration in schizophrenia: An event-related potential study

Cited by 63 publications

References 41 publications

Reduced frontal theta oscillations indicate altered crossmodal prediction error processing in schizophrenia

Reduced frontal theta oscillations indicate altered crossmodal prediction error processing in schizophrenia

Early Integration Processing between Faces and Vowel Sounds in Human Brain: An MEG Investigation

Adapting the Crossmodal Congruency Task for Measuring the Limits of Visual–Tactile Interactions Within and Between Groups

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