Deficient levels of dietary selenium suppress the antibody response in first and second generation mice

Mulhern, Sally A.; Taylor, G.L.; Magruder, Louise; Vessey, Adele R.

doi:10.1016/s0271-5317(85)80036-1

Cited by 38 publications

(15 citation statements)

References 28 publications

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“…Thus, a relatively narrow range of selenium concentrations must be maintained for optimal function of the immune system. 2,3,7,12,13,16,21,25,27,29,30,32 This study and results of a field investigation failed to clarify the association between subclinical selenium toxicosis and abortion/perinatal mortality. However, data from a limited number of animals suggest that current values indicative of perinatal selenium toxicosis (Ն3 ppm) may underestimate the resistance of animals to chronic selenium toxicosis and that marked elevations in hepatic selenium concentration (Ͼ9 ppm) may be clinically relevant.…”

Section: Discussionmentioning

confidence: 79%

The Effect of Subclinical Selenium Toxicosis on Pregnant Beef Cattle

et al. 1998

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Abstract. A field investigation conducted by the South Dakota Animal Disease Research and DiagnosticLaboratory suggested that subclinical selenium toxicosis in pregnant cows may have contributed to an outbreak of aborted/stillborn calves in a high-selenium region of South Dakota. This study was undertaken to evaluate the relationship between abortion and subclinical selenium toxicosis in the dam and to assess the effects of subclinical selenium toxicosis on the bovine immune system. Fifteen pregnant cows were fed diets containing 0.25 (control), 6.0, and 12.0 ppm selenium beginning at 80-110 days gestation. Although selenium toxicosis has been reported to cause abortion, this study failed to reproduce abortions. A single cow in the 12-ppm selenium treatment group gave birth to a weak calf, which subsequently died. This calf had myocardial lesions consistent with those described for selenium toxicosis and had hepatic selenium levels of 9.68 ppm (wet weight). Elevated dietary selenium resulted in the depression of several leukocyte function parameters in pregnant cows. A statistically significant depression in forced antibody response was identified in both selenium-supplemented groups. A significantly diminished mitogenic response to concanavalin A and pokeweed mitogen was also observed in the 12-ppm selenium group. Although a similar pattern of depression was also observed with phytohemagglutinin, differences were not significant. These findings indicate that even in the absence of clinical alkali disease, elevated selenium levels may adversely affect both pregnancy outcome and the bovine immune system.

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Section: Discussionmentioning

confidence: 79%

The Effect of Subclinical Selenium Toxicosis on Pregnant Beef Cattle

et al. 1998

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“…One of the first clues that Se is involved in immune responses was uncovered in 1959 by McConnell [56], who injected 75 Se into dogs and demonstrated isotope incorporation into leukocytes. Since those early experiments, Se has been shown to be utilized by nearly all tissues and cell types, including those involved in innate and adaptive immune responses [4,14,58,60]. Agricultural animal studies have provided insight into the effects of Se deficiency or Se supplementation on immune responses to a wide variety of vaccines (reviewed in [78]).…”

Section: The Influence Of Selenium On the Immune Systemmentioning

confidence: 99%

“…In general, these studies have demonstrated an enhancement of both cell-mediated and humoral immune responses by increasing levels of Se intake. In experimental animal studies, Se deficiency has been shown to result in less robust immune responses to viruses, tumors, and allergens compared with Se-adequate controls [8,37,60,63,68]. However, the results are less clear regarding the benefits of Se supplementation above adequate levels in conferring additional immunological protection.…”

Section: The Influence Of Selenium On the Immune Systemmentioning

confidence: 99%

Mechanisms by which selenium influences immune responses

Hoffmann

2007

Arch. Immunol. Ther. Exp.

121

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Selenium (Se) is an essential dietary trace element that influences immune responses through its incorporation into selenoproteins as the amino acid selenocysteine. This review summarizes data available to date regarding the mechanisms by which Se exerts its effects on inflammation and immune responses. This includes the effects of Se on phagocytes as well as effects on lymphocyte activation, proliferation, and differentiation. Also examined are the known functions of individual selenoproteins for regulating reactive oxygen species and redox potential in leukocytes. Overall, determining how Se contributes to optimal immune responses will depend on a better understanding of the mechanisms by which the selenoproteins, individually and collectively, shape inflammation and immune responses.

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“…https://doi.org/10.1079/PNS19910037 Downloaded from https://www.cambridge.org/core. IP address: 18.236.120.13, on 12 May 2018 at 14:52:37, subject to the Cambridge Core terms of use, cells too are affected (Mulhern et al 1985). If weanling mice are maintained on a Se-vitamin E-deficient diet, production of IgM is more rapidly impaired (Spallholz, 1981a).…”

Section: A N T I B O D Y P R O D U C T I O Nmentioning

confidence: 99%

“…1 Spallholz (1981a) Mulhern et al (1985) Se-, Se deficient; Set, Se adequate; Se++, supplementary Se; E-, vitamin E deficient; E+, vitamin E adequate; SRBC, sheep erythrocytes; 1, less than controls; +, not different from controls; t , greater than controls.…”

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confidence: 99%