Deficient insulin-like growth factor I in chronic heart failure predicts altered body composition, anabolic deficiency, cytokine and neurohormonal activation

Niebauer, Josef; Pflaum, Claus Dieter; Clark, Andrew L.; Strasburger, Christian J.; Hooper, James; Poole‐Wilson, Philip A.; Coats, Andrew J.S.; Anker, Stefan D.

doi:10.1016/s0735-1097(98)00226-5

Cited by 181 publications

(101 citation statements)

References 29 publications

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“…25,26 Niebauer et al detected relatively high circulating concentrations of tumor necrosis factor-, epinephrine and norepinephrine in chronic heart failure patients whose IGF-1 levels were low. 27 Other previous studies have also shown increased circulating concentrations of various inflammatory cytokines in patients with CHF. 28 In the present study, the circulating concentration of IGFBP-1 was increased and that of IGF-1 decreased in patients with HF-HCM, and the IGFBP-1 elevation may have been induced by an increase in inflammatory cytokines and epinephrine.…”

Section: Circulating Concentrations Of Igfbpsmentioning

confidence: 83%

Circulating Levels of Insulin-Like Growth Factor-1 and Its Binding Proteins in Patients With Hypertrophic Cardiomyopathy.

Saya

Hamada

Hiwada

2002

Circ J

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Section: Circulating Concentrations Of Igfbpsmentioning

confidence: 83%

Circulating Levels of Insulin-Like Growth Factor-1 and Its Binding Proteins in Patients With Hypertrophic Cardiomyopathy.

Saya

Hamada

Hiwada

2002

Circ J

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“…However, we found no association between low total IGF-I level and CHF. Prior studies have linked changes in circulating IGF-I with onset and progression of CHF (24,44,45). Among patients with obstructive or non-obstructive hypertrophic cardiomyopathy, IGF-I increases prior to the onset of CHF, and then decreases below control levels after CHF onset (24).…”

Section: Discussionmentioning

confidence: 99%

High insulinlike growth factor binding protein 1 level predicts incident congestive heart failure in the elderly

Kaplan¹,

McGinn²,

Pollak³

et al. 2008

American Heart Journal

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Background-Low insulin-like growth factor-1 (IGF-I) may influence the development of agerelated cardiovascular diseases including congestive heart failure (CHF). Insulin-like growth factor binding protein-1 (IGFBP-1), which increases during catabolic states and inhibits anabolic IGF-I effects, is increased in CHF patients and has been associated prospectively with increased mortality among older adults and myocardial infarction survivors. We investigated the association between fasting plasma levels of IGF-I, IGFBP-1, IGFBP-3, and insulin and risk of incident CHF in the prospective Cardiovascular Health Study (CHS).

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“…Thus, IGF-I has been found to be positively associated with progression of coronary artery stenosis and restenosis (8,9) and coronary artery disease (12). Heart failure has been found to be associated with low IGF-I (13)(14)(15)(16). In some studies on patients with heart failure, positive effects of GH or IGF-I on cardiac function have been found (17,18), whereas these effects could not be reproduced in other studies (19,20).…”

Section: Introductionmentioning

confidence: 99%

Associations of age-dependent IGF-I SDS with cardiovascular diseases and risk conditions: cross-sectional study in 6773 primary care patients

Schneider¹,

Klotsche²,

Saller³

et al. 2008

European Journal of Endocrinology

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Objective: We aimed at investigating the association of age-dependent IGF-I SDS with diabetes, dyslipidemia, hypertension, and heart diseases, in a large patient sample. Background: IGF-I has been suggested to be associated with several diseases and a prognostic marker for the development of cardiovascular diseases and risk factors. The findings, though, have been inconsistent possibly due to the methodological factors. Methods: We studied 6773 consecutive primary care patients, aged 18C years, in a cross-sectional, epidemiological study in primary care, Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment study. All patients underwent a standardized clinical diagnostic and laboratory assessment. IGF-I levels were measured with an automated chemiluminescence assay system. We calculated the odds ratios (OR) for diseases in quintiles of IGF-I, and additionally analyzed the association of age-dependent IGF-I SDS with these conditions. Results: After multiple adjustments for confounders, we found increased ORs for coronary artery disease in patients with high IGF-I. Women, but not men, with low IGF-I also showed increased ORs for coronary artery disease. Dyslipidemia was positively associated with IGF-I. Type 2 diabetes showed a curvilinear association with IGF-I SDS. Conclusions: The findings suggest the existence of multiple and complex interactions between IGF-I and several health conditions. The complex nature of disease-and subgroup-specific associations along with the methodological factors can be held responsible for divergent findings in previous studies. European Journal of Endocrinology 158 153-161

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Deficient insulin-like growth factor I in chronic heart failure predicts altered body composition, anabolic deficiency, cytokine and neurohormonal activation

Abstract: Patients with low insulin-like growth factor I levels show signs of altered body composition, cytokine and neuroendocrine activation, to a greater extent than patients with normal/high levels.

Cited by 181 publications

References 29 publications

Circulating Levels of Insulin-Like Growth Factor-1 and Its Binding Proteins in Patients With Hypertrophic Cardiomyopathy.

Circulating Levels of Insulin-Like Growth Factor-1 and Its Binding Proteins in Patients With Hypertrophic Cardiomyopathy.

High insulinlike growth factor binding protein 1 level predicts incident congestive heart failure in the elderly

Associations of age-dependent IGF-I SDS with cardiovascular diseases and risk conditions: cross-sectional study in 6773 primary care patients

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