Deficient human immunodeficiency virus type 1-specific cytotoxic T cell responses in vertically infected children

Luzuriaga, Katherine; Koup, Richard A.; Pikora, Cheryl; Brettler, Doreen B.; Sullivan, John L.

doi:10.1016/s0022-3476(05)80732-2

Cited by 102 publications

(60 citation statements)

References 23 publications

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“…This different pattern might reflect a different efficiency of the immune system in controlling infection, and could explain why most infants, including those in the slow progressor group, have a shorter clinical latent phase (2-4 yr) than usually observed in adults (8-10 yr) (1). The finding that HIV-1 specific CTL are only seldom detected in infected newborns (38,39) is in line with the above suggestion. The selective loss of naive CD8ϩ cells, recently demonstrated in HIV-1 infected infants (40), may also contribute to the defects in cellmediated immunity.…”

Section: Discussionsupporting

confidence: 87%

Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection.

Rossi¹,

Masiero²,

Giaquinto³

et al. 1996

J. Clin. Invest.

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About one-third of vertically HIV-1 infected infants develop AIDS within the first months of life; the remainder show slower disease progression. We investigated the relationship between the pattern of HIV-1 replication early in life and disease outcome in eleven infected infants sequentially studied from birth. Viral load in cells and plasma was measured by highly sensitive competitive PCR-based methods.Although all infants showed an increase in the indices of viral replication within their first weeks of life, three distinct patterns emerged: ( a ) a rapid increase in plasma viral RNA and cell-associated proviral DNA during the first 4-6 wk, reaching high steady state levels ( Ͼ 1,000 HIV-1 copies/10 5 PBMC and Ͼ 1,000,000 RNA copies/ml plasma) within 2-3 mo of age; ( b ) a similar initial rapid increase in viral load, followed by a 2.5-50-fold decline in viral levels; ( c ) a significantly lower ( Ͼ 10-fold) viral increase during the first 4-6 wk of age. All infants displaying the first pattern developed early AIDS, while infants with slower clinical progression exhibited the second or third pattern.These findings demonstrate that the pattern of viral replication and clearance in the first 2-3 mo of life is strictly correlated with, and predictive of disease evolution in vertically infected infants. ( J. Clin. Invest. 1996. 97:323-330.)

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Section: Discussionsupporting

confidence: 87%

Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection.

Rossi¹,

Masiero²,

Giaquinto³

et al. 1996

J. Clin. Invest.

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“…16 In this study, expanded populations of CD8 ϩ CD57 ϩ and CD8ϩDRϩ T lymphocytes were found in the peripheral blood of infants who had persistently detectable plasma HIV-1 RNA during treatment (data not shown). These lymphocyte populations were not expanded in Patients 2 and 3.…”

Section: Effects Of Treatment On Lymphocytesmentioning

confidence: 67%

Combination Treatment with Zidovudine, Didanosine, and Nevirapine in Infants with Human Immunodeficiency Virus Type 1 Infection

et al. 1997

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“…It is important to establish whether cellular, specifically CTL responses, have any role in favouring either of these clinical outcomes. While CTL responses to HIV have been reported in a number of studies of HIV-infected children [6][7][8], HIVspecific CTL have also been described in children who subsequently became antibody-negative [9]. and it ts important to determine whether these children have successfully cleared virus and become naturally immunized.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic T lymphocyte activity and CD8 subpopulations in children at risk of HIV infection

Aldhous

Watret²,

Mok

et al. 1994

Clinical and Experimental Immunology

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SUMMARYHIV-specific cytotoxic T lymphocytes (CTL) are thought to play a major role in viral control in HIV-infected adults. Changes in the relative proportions of CDS lymphocyte subpopulations are also thought to be associated with disease progression. Less is known about the relative effectiveness of CTL against different HIV targets, or about the relationship, if any. between CTL activity and CDS subpopuiations. We have measured CTL activity against four HIV gene products (gag. tat. pal and en\) and expression of CD45RO, CD45RA. HLA-DR, CD29. S6F1, and CD57 surface markers on CDS cells from nine HIV-infected and 11 HIV-uninfected children. Of nine HIV-infected children, six showed antigen-specific CTL activity on at least one occasion: 4/6 directed against tat, 6/6 against pol, 1/6 against env, and 1/6 against gag. However, the specificity of the CTL activity varied between children and within individual children with time. Furthermore, two uninfected children showed CTL activity, one to HW-gag. -pot and -tat. and the other to HW-pot. All the HIV-infected and two uninfected children had abnormal proportions of CDS subpopulations in whole blood compared with age-matched controls. There was no correlation between CTL activity and CDS subsets in whole blood. Five children changed from CTL-positive to CTL-negative (or vice versa) during the study. In these, the occasions when CTL activity was detected coincided with an increase in CDS cells, an expansion of HLA-DR^ CD8 cells and a loss of CD45RA ' CDS cells.

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Deficient human immunodeficiency virus type 1-specific cytotoxic T cell responses in vertically infected children

Cited by 102 publications

References 23 publications

Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection.

Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection.

Combination Treatment with Zidovudine, Didanosine, and Nevirapine in Infants with Human Immunodeficiency Virus Type 1 Infection

Cytotoxic T lymphocyte activity and CD8 subpopulations in children at risk of HIV infection

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