Deficient auditory processing in children with Asperger Syndrome, as indexed by event-related potentials

Jansson-Verkasalo, Eira; Čėponiené, Rita; Kielinen, Marko; Suominen, Kalervo; Jäntti, V.; Linna, Sirkka Liisa; Moilanen, Irma; Näätänen, Risto

doi:10.1016/s0304-3940(02)01405-2

Cited by 125 publications

(119 citation statements)

References 10 publications

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“…Interestingly, individual differences in temporal resolution were positively related to speech-in-noise perception in the ASD sample, which suggests that impaired temporal perception at the ms scale may impact upon speech and language learning, possibly through less optimal consonant discrimination (Bhatara et al 2013). This fits with findings of electrophysiological studies showing reduced automatic discrimination of consonants in ASD (e.g., Jansson-Verkasalo et al 2003;Kuhl et al 2005;Russo et al 2009). …”

Section: Discussionsupporting

confidence: 90%

“…Superior pitch processing has been established regardless of stimulus complexity (e.g., for pure tones, complex tones, contours, nonwords, words and sentences) using a variety of psychophysical tasks (e.g., identification, discrimination, categorization, memory and labeling) (e.g., Bonnel et al 2003Bonnel et al , 2010Heaton 2005;Heaton et al 2008a, b, c;Järvinen-Pasley and Heaton 2007;Jones et al 2009;O'Riordan and Passetti 2006;Stanutz et al 2014). The majority of research using event-related potentials (ERP) also revealed enhanced neural detection of frequency changes in ASD at the pre-attentive level (using mismatch negativity or MMN) (e.g., Ferri et al 2003;Gomot et al 2002;Kujala et al 2007; but see Jansson-Verkasalo et al 2003; see Haesen et al 2011 for an extensive recent review of the psychophysical and electrophysiological literature on auditory processing in ASD). Relevant is also the increased prevalence of absolute pitch and musical savants in the ASD population (e.g., DePape et al 2012;Heaton et al 2008a, b, c;Miller 1989;Mottron et al 2013) and the increased prevalence of autistic traits among possessors of absolute pitch (e.g., Dohn et al 2012).…”

Section: Introductionmentioning

confidence: 99%

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Fragile Spectral and Temporal Auditory Processing in Adolescents with Autism Spectrum Disorder and Early Language Delay

Boets

Verhoeven

Wouters

et al. 2014

J Autism Dev Disord

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We investigated low-level auditory spectral and temporal processing in adolescents with autism spectrum disorder (ASD) and early language delay compared to matched typically developing controls. Auditory measures were designed to target right versus left auditory cortex processing (i.e. frequency discrimination and slow amplitude modulation (AM) detection versus gap-in-noise detection and faster AM detection), and to pinpoint the task and stimulus characteristics underlying putative superior spectral processing in ASD. We observed impaired frequency discrimination in the ASD group and suggestive evidence of poorer temporal resolution as indexed by gapin-noise detection thresholds. These findings question the evidence of enhanced spectral sensitivity in ASD and do not support the hypothesis of superior right and inferior left hemispheric auditory processing in ASD.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Fragile Spectral and Temporal Auditory Processing in Adolescents with Autism Spectrum Disorder and Early Language Delay

Boets

Verhoeven

Wouters

et al. 2014

J Autism Dev Disord

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“…Whereas studies of MMN/MMF in autism show conflicting results in children with ASD compared to TD controls , Jansson-Verkasalo E 2003, studies from our group revealed delayed MMF responses in autism (with language impairment) compared to age-matched TD controls, with delays in subjects with autism up to 50ms (Oram Cardy et al 2005a). Delays did not appear to be specific to speech, as delays were equivalent for vowel contrasts (/u/ vs. /a/) and acoustically matched tone contrasts (300Hz vs. 700Hz sinusoidal tones).…”

Section: Mismatch Field and Change Detectionmentioning

confidence: 59%

Electrophysiological signatures: Magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders

Roberts

Schmidt

Egeth

et al. 2008

International Journal of Psychophysiology

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While magnetoencephalography (MEG) is of increasing utility in the assessment of pediatric patients with seizure disorders, this indication reflects only a part of the clinical potential of the technology. Beyond epilepsy, a broad range of developmental psychiatric disorders require the combined offerings of spatial and temporal resolution, along with direct sensitivity to neural electrical activity, that are offered by MEG. This article reviews the application of MEG in the study of auditory processing as an aspect of language impairment in children. Potential application is elaborated in the clinical case of autism spectrum disorders, a devastating disorder with prevalence of 1 in 150, poorly served by alternative imaging modalities. MEG offers both spatial and temporal insights, tentatively described as "electrophysiological signatures". Results demonstrate the sensitivity of MEG for detection of abnormalities of auditory processing in ASD and their clinical correlates. These findings offer promise for the comprehensive assessment of developmental neuropsychiatric disorders such as autism, but also suggest avenues for the development of MEG technology to adequately meet the needs of such populations, as well as providing conduits to basic sciences including neurobiology and genetics.

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“…Evidence from cortical auditory evoked potentials in autism, especially mismatch negativity (MMN) evidence, suggests that children with autism have difficulty encoding auditory information into transient memory (Bomba and Pang 2004;Seri et al 1999;Jansson-Verkasalo et al 2003; for a review see Groen et al 2008). MMN reflects the neural processing that is required when an incoming auditory stimulus is processed against stimulus representations that are already stored in transient auditory memory.…”

Section: Discussionmentioning

confidence: 99%

Intact Spectral but Abnormal Temporal Processing of Auditory Stimuli in Autism

Groen

Orsouw

Huurne

et al. 2009

J Autism Dev Disord

102

105

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The perceptual pattern in autism has been related to either a specific localized processing deficit or a pathway-independent, complexity-specific anomaly. We examined auditory perception in autism using an auditory disembedding task that required spectral and temporal integration. 23 children with high-functioning-autism and 23 matched controls participated. Participants were presented with two-syllable words embedded in various auditory backgrounds (pink noise, moving ripple, amplitude-modulated pink noise, amplitude-modulated moving ripple) to assess speech-in-noise-reception thresholds. The gain in signal perception of pink noise with temporal dips relative to pink noise without temporal dips was smaller in children with autism (p = 0.008). Thus, the autism group was less able to integrate auditory information present in temporal dips in background sound, supporting the complexity-specific perceptual account.

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Deficient auditory processing in children with Asperger Syndrome, as indexed by event-related potentials

Cited by 125 publications

References 10 publications

Fragile Spectral and Temporal Auditory Processing in Adolescents with Autism Spectrum Disorder and Early Language Delay

Fragile Spectral and Temporal Auditory Processing in Adolescents with Autism Spectrum Disorder and Early Language Delay

Electrophysiological signatures: Magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders

Intact Spectral but Abnormal Temporal Processing of Auditory Stimuli in Autism

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