Deficiency of Prothrombin and Proconvertin After Therapy With Propylthiouracil

Haemorrhage following thyroidectomy for thyrotoxicosis

“…Haemorrhagic states following the administration of propyl-thiouracil have been subdivided into two groups, namely, those associated with depression of the bone marrow and thrombocytopenia (Fewell and others, 1950;McGavack and Chevalley, I954), and those associated with hypoprothrombinaemia (Craddock and others, 1951;Goldstein, 1951 ;D'Angelo and Gresley, 1959;Mirrer, 1955;Kolars and Gonyea, 1959;Naeye and Terrien, 1960). The latter appeared to consist of a true hypoprothrombinaemia as well as factors V and VII deficiencies.…”

“…Coagulation defects are much less common and have been recorded only as complications of propyl-thiouracil therapy (Fewell, Engel, and Zimmerman, 1950;Craddock, Shotton, Crockett, and Leavell, 1951;Goldstein, 1951;McGavack and Chevalley, 1954;Mirrer, 1955;D'Angelo and Gresley, 1959;Kolars and Gonyea, 1959;Naeye and Terrien, 1960). The defects consisted of hypoprothrombinaemia, associated with deficiencies of factors V and VII.…”