Deficiency of Pdcd10 causes urothelium hypertrophy and vesicle trafficking defects in ureter
Yixuan Wang,
Baotao Ma,
Youli Jian
et al.
Abstract:The scaffolding protein programmed cell death protein 10 (Pdcd10) has been demonstrated to play a critical role in renal epithelial cell homeostasis and function by maintaining appropriate water reabsorption in collecting ducts. Both ureter and kidney collecting duct systems are derived from the ureter bud during development. Here, we report that cadherin‐16 (Cdh16)‐cre drives gene recombination with high specificity in the ureter, but not the bladder, urothelium. The consequences of Pdcd10 deletion on the str… Show more
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